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| 1 | In vitro total phenolics,flavonoids contents and antioxidant activity of essential oil,various organic extracts from the leaves of tropical medicinal plant Tetrastigma from Sabah显示文摘Objective:To detect the in vitro total phenolics,flavonoids contents and antioxidant activity of essential oil,various organic extracts from the leaves of tropical medicinal plant Tetrastigma from Sabah.Methods:The dry powder leaves of Tetrastigma were extracted with different organic solvent such as hexane.ethyl acetate,chloroform,butanol and aqueous methanol.The total phenolic and total flavonoids contents of the essential oil and various organic extracts such as hexane,ethyl acetate,chloroform,butanol and aqueous ethanol were determined by Folin-Ciocalteu method and the assayed antioxidant activity was determined in vitro models such as antioxidant capacity by radical scavenging activity usingα,α-diphenyl-β-picrylhydrazyl (DPPH) method.Results:The total phenolic contents of the essential oil and different extracts as gallic acid equivalents were found to be highest in methanol extract(386.22 mg/g) followed by ethyl acetate(190.89 mg/g).chloroform(175.89 mg/g).hexane(173.44 mg/g).and Imtanol extract (131.72 mg/g) and the phenolic contents not detected in essential oil.The antioxidant capacity of the essential oil and different extracts as ascorbic acid standard was in the order of methanol extract>ethyl acetate extract>chloroform>butanol>hexane extract also the antioxidant activity was not detected in essential oil.Conclusions:The findings show that the extent of antioxidant activity of the essential oil and all extracts are in accordance with the amount of phenolics present in that extract.Leaves of Tetrastigma being rich in phenolics may provide a good source of antioxidant. | M Amzad Hossain Muhammad Dawood Shah Charles Gnanaraj Muhammad Iqbal | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 9 |
| 2 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 3 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 4 | Tumor necrosis factor-mediates cardiac remodeling and ventrieular dysfunction after pressure overload state显示文摘 | Sun M Chen M Dawood F | 2007 | Circulation2007，115，11： | 1 |
| 5 | Flexural strength design of concrete beams reinforced with high-strength steel bars 显示文摘 | Mast R F Dawood M Rizkalla S H | 2008 | ACI Structural Journal2008，105，5： | 1 |
| 6 | Tumor necrosis factor-alpha medi- ates cardiac remodeling and ventricular dysfunction after pressure overload state显示文摘 | Sun M Chen M Dawood F | 2007 | Circulation2007，，11： | 1 |
| 7 | Multipath and ground clutter analysis for a UWB noise radar 显示文摘 | Dawood M Narayanan R M | 2002 | IEEE Transaction on Aerospace and Electronic System2002，38，3： | 1 |
| 8 | Proposed design guidelines for strengthening of steel bridges with FRP materials 显示文摘 | Schnereh D Dawood M Rizkalla S | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 9 | Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state 显示文摘 | SUN M CHEN M DAWOOD F | 2007 | Circulation2007，115，11： | 1 |
| 10 | Flexural strength design of concrete beams reinforced with high-strength steel bars 显示文摘 | Mast R F Dawood M Rizkalla S H | 2008 | ACI Structural Journal2008，105，5： | 1 |
| 11 | Tumor necrosis factoralpha mediates cardiac remodeling and ventriculardysfunction after pressure overload state显示文摘 | Sun M Chen M Dawood F | 2007 | Circulation2007，115，11： | 1 |
| 12 | Proposed Design Guidelines for Strengthening of Steel Bridges with FRP Materials显示文摘 | Schnerch D Dawood M Rizkalla S | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 13 | Mechanical properties of high strength flowing concrete with hybrid fibers 显示文摘 | Dawood E T Ramli M | 2012 | Construction and Building Materials2012，28，1： | 1 |
| 14 | Vascular endothelial growth factor and interleukin-6 in peritoneal fluid of women with endometriosis 显示文摘 | Mahnke J L Dawood M Y Huang J C | 2000 | Fertil Steril2000，73，1： | 1 |
| 15 | Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state显示文摘 | Chen M Dawood F | 2007 | Circulation2007，115，11： | 1 |
| 16 | Primary dysmenorrhea: advances in pathogenesis and management 显示文摘 | Dawood M Yusoff M D | 2006 | Obstet Gynecol2006，108，2： | 1 |
| 17 | Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction 显示文摘 | Ayach BB Yoshimitsu M Dawood F | 2006 | Proc Natl Acad Sci USA2006，103，7： | 1 |
| 18 | Generalised wideband ambiguity function of a coherent ultrawideband random noise radar显示文摘 | DAWOOD M NARAYANAN R M | 1994 | IEE Proceedings of Radar Sonar and Nav- igation1994，150，5： | 1 |
| 19 | Hyperhomocys-teinemia as a risk factor for ischemic heart disease显示文摘 | Aamir M Sattar A Dawood MM | 2004 | CollPhys Surg Pak2004，14，： | 1 |
| 20 | Mechanisms and management of doxombicin cardio toxicity显示文摘 | Shi Y Moon M Dawood S | 2011 | Herz2011，36，4： | 1 |
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