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| 1 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 2 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 3 | Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation显示文摘AIM:To investigate genetic diversity of Helicobacter pylori (H.pylori) cell division-related gene A (cdrA) and its effect on the host response.METHODS:Inactivation of H.pylori cdrA,which is involved in cell division and morphological elongation,has a role in chronic persistent infections.Genetic property of H.pylori cdrA was evaluated using polymerase chain reaction and sequencing in 128 (77 American and 51 Japanese) clinical isolates obtained from 48 and 51 patients,respectively.Enzyme-linked immunosorbent assay was performed to measure interleukin-8 (IL-8) secretion with gastric biopsy specimens obtained from American patients colonized with cdrA-positive or-negative strains and AGS cells cocultured with wild-type HPK5 (cdrA-positive) or its derivative HPKT510 (cdrA-disruptant).Furthermore,the cytotoxin-associated gene A (cagA) status (translocation and phosphorylation) and kinetics of transcription factors [nuclear factor-kappa B (NF-κB) and inhibition kappa B] were investigated in AGS cells co-cultured with HPK5,HPKT510 and its derivative HPK5CA (cagA disruptant) by western blotting analysis with immunoprecipitation.RESULTS:Genetic diversity of the H.pylori cdrA gene demonstrated that the cdrA status segregated into two categories including four allele types,cdrA-positive (allele types;Ⅰand Ⅱ) and cdrA-negative (allele types;Ⅲ and Ⅳ) categories,respectively.Almost all Japanese isolates were cdrA-positive (Ⅰ:7.8% and Ⅱ:90.2%),whereas 16.9% of American isolates were cdrA-positive (Ⅱ) and 83.1% were cdrA-negative (Ⅲ:37.7% and Ⅳ:45.5%),indicating extended diversity of cdrA in individual American isolates.Comparison of each isolate from different regions (antrum and corpus) in the stomach of 29 Americans revealed that cdrA status was identical in both isolates from different regions in 17 cases.However,12 cases had a different cdrA allele and 6 of them exhibited a different cdrA category between two regions in the stomach.Furthermore,in 5 of the 6 cases possessing a different cdrA category,cdrA-negative isolate existed in the corpus,suggesting that cdrA-negative strain is more adaptable to colonization in the corpus.IL-8 secretions from AGS revealed that IL-8 levels induced by a cdrA-disrupted HPKT510 was significantly lower (P < 0.01) compared to wildtype HPK5:corresponding to 50%-60% of those of wild-type HPK5.These data coincided with in vivo data that an average value of IL-8 in biopsy specimens from cdrA-positive and cdrA-negative groups was 215.6 and 135.9 pg/mL,respectively.Western blotting analysis documented that HPKT510 had no effect on CagA translocation and phosphorylation,however,nuclear accumulation of NF-κB was lower by HPKT510 compared to HPK5.CONCLUSION:Colonization by a cdrA-negative or cdrA-dysfunctional strain resulted in decreased IL-8 production and repression of NF-κB,and hence,attenuate the host immunity leading to persistent infection. | Hiroaki Takeuchi Ya-Nan Zhang Dawn A Israel Richard M Peek Jr Mikio Kamioka Hideo Yanai Norihito Morimoto Tetsuro Sugiura | 2012 | World Journal of Gastroenterology2012，18，5： | 3 |
| 4 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 5 | Endothelial cell seeding with rotation of a ventricular blood sac显示文摘 | Dawn M Wankowski Mark M | 1994 | ASAIO Journal1994，40，： | 1 |
| 6 | Marchiafava-Bignami disease:Two cases with magnetic resonance imaging and positron e- mission tomography scan findings 显示文摘 | NALINI A KOVOOR J M DAWN R | 2009 | Neurol India2009，57，5： | 1 |
| 7 | Ground vibrations from Passing Trains显示文摘 | Dawn T M Stanworth C G | 1979 | Journal of Sound and Vibration1979，66，3： | 1 |
| 8 | Bone marrow-derived pluripotent very small embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction 显示文摘 | Zuba-Surma EK Kucia M Dawn B | 2008 | J Mol Cell Cardiol2008，44，： | 1 |
| 9 | Sustained activation of p38MAPK mitogen-activated protein kinase contributes to the vascular response to injury显示文摘 | Haisong J Sandhya N Charles FS Alan RO Rosanna M Dawn Z | 2002 | Pharmacology and Experimental Therapeutics2002，301，1： | 1 |
| 10 | A modeling and analysis methodology for modular logic controllers of machining systems using Petri net formalism显示文摘 | EUISU P DAWN M T PRAMOD P K | 2001 | IEEE Transactions on systems man and cybernetics-Part C:Applications reviews2001，31，2： | 1 |
| 11 | Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123显示文摘 | Stephen L Hempel Garry R Buettner Yunxia Q O’Malley Duane A Wessels Dawn M Flaherty | 1999 | Free Radical Biology and Medicine1999，，1： | 1 |
| 12 | A modeling and analysis methodology for modular logic controllers of machining systems using Petri net formalism显示文摘 | EUISU P DAWN M T PRAMOD P K | 2001 | IEEE Transactions on Systems Man and Cybernetics-Part C:Applications and Reviews2001，31，2： | 1 |
| 13 | Ground vibration from passing trains显示文摘 | Dawn T M | 1979 | Sound & Vibration1979，66，3： | 1 |
| 14 | A Mathematical model of the solid polymer electrolyte fuel cell 显示文摘 | Dawn M Bernardi Mark W Verbrugge | 1992 | Journal of the Electrochemical Society1992，139，9： | 1 |
| 15 | In search of brand image:A foundation analysis显示文摘 | DOBNI DAWN ZINKHAN G M | 1990 | Advances in Consumer Research1990，17，1： | 1 |
| 16 | Bone marrow-derived pluripotent very smal embryonic-like stem cells (VSELs) are mobilized after acute myocardial infarction显示文摘 | Zuba-Surma EK Kucia M Dawn B | | 0，，05： | 1 |
| 17 | Electrode-reducing microorganisms that harvest energy from marine sediments 显示文摘 | Bond D R Dawn E H Leonard M T | 2002 | Science2002，295，18： | 1 |
| 18 | Retinol administration to superovulated ewes improves in vitro embryonic viability显示文摘 | Dawn M Eberhardt Whitney A Will James D Godkin | 1999 | Biol Reprod1999，60，： | 1 |
| 19 | Cells Expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction 显示文摘 | Kucia M Dawn B Hunt G | 2004 | Circ Res2004，95，12： | 1 |
| 20 | β-cell Mass dynamics in Zucker diabetic fatty rats: Rosiglitazone prevents the rise in net cell death显示文摘 | Diane T Finegood M Dawn McArthur | 2001 | Diabetes2001，50，： | 1 |
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