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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Bose-Einstein condensation in a gas of sodium atoms显示文摘 | DAVIES K B MEWES M O ANDERSON M R | 1995 | Phys Rev Lett1995，75，22： | 2 |
| 3 | The purification and characterization of extremely thermostable α-amylase from the hyperthmophilic archaebacterium Pyrococcus furiosus显示文摘 | Laderman K A Davis B R Krutzsch H C | 1993 | The Journal of Biological Chemistry1993，268，24： | 1 |
| 4 | Hexachlorobenzene in hazardous waste sites显示文摘 | DAVIS B D MORGAN R C | 1986 | IARC Sci Publ1986，77，： | 1 |
| 5 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 6 | Di-( 2-ethylhexyl ) phthalate suppresses estradiol and ovulation in cycling rats 显示文摘 | Davis B J Maronpot R R Heindel J J | 1994 | Tox- icol Appl Pharmacol1994，128，2： | 1 |
| 7 | Three-dimensionalseismic imaging of dikefed submarine volcanoes显示文摘 | Davies R Bell B Cartwright J A | 2002 | Geology2002，30，： | 1 |
| 8 | Refinement of weedrisk assessments for biofuels using Camelina sativa as a modelspecies显示文摘 | Davis P B Menalled F D Peterson R K D | 2011 | Journal of Applied Ecology2011，48，： | 1 |
| 9 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 10 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 11 | The expression of calbindin in chicks that are divergently selected for low or high incidence of tibial dyschondroplasia显示文摘 | SHIRLEY R B DAVIS A J COMPTON M M | 2003 | Poultry Science2003，82，12： | 1 |
| 12 | Dynamic measurement of the viscoelastic properties of skin 显示文摘 | Pereira J M Mansour J M Davis B R | 1991 | Journal of Biomechanics1991，24，： | 1 |
| 13 | The research potential of practice nurses显示文摘 | Davies J Heyman B Bryar R | 2002 | Health and Social Care in the Community2002，10，： | 1 |
| 14 | Genetics of Parkinsonism:A review显示文摘 | VAUGHAN J R DAVIS M B WOOD N W | 2001 | Annals of Human Genetics2001，65，2： | 1 |
| 15 | Dynamic recrystallization of Mg and Mg-Y alloys: crystallographic texture development显示文摘 | COTTAM R ROBSONB J LORIMER G DAVIS B | 2008 | Materials Science and Engineering A2008，485，12： | 1 |
| 16 | The Stability of Low Radial Immersion Milling 显示文摘 | DAVIES M A DUTTERER B PRATT J R | 2000 | Annals of the CIRP2000，49，1： | 1 |
| 17 | Energy dissipation and seksmic liquefaction in sands 显示文摘 | Davis R O Berrill J B | 1982 | Earthquake Engineering and Structure Dynamics1982，10，1： | 1 |
| 18 | Overexpres sion of brain-derived neurotrophic factor enhances sensory in nervation and selectively increases neuron number显示文摘 | LeMaster A M Krimm R F Davis B M | 1999 | J Neu rosci1999，19，14： | 1 |
| 19 | Cathelicidins: Microbicidal activity, mechanisms of action, and roles in in- nate immunity显示文摘 | Ramanathan B Davis E G Ross C R et a l | 2002 | Microb Infect2002，4，： | 1 |
| 20 | Trust, Expertise and Ecommerce Intermediary Adoption 显示文摘 | Chircu A M Davis G B Kauffman R J | 2000 | In Proceedings of the Sixth Americas Conference on Information System2000，，8： | 1 |
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