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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | X-ray interactions: photabsorption, scattering, transmission, and reflection at E-50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Tables1993，54，： | 2 |
| 3 | Rainbow trout has two genes for growth hormone显示文摘 | Agellon L B Davies S L Lin C M | 1988 | Mol Rep Develop1988，1，： | 1 |
| 4 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 5 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 6 | The purification and characterization of extremely thermostable α-amylase from the hyperthmophilic archaebacterium Pyrococcus furiosus显示文摘 | Laderman K A Davis B R Krutzsch H C | 1993 | The Journal of Biological Chemistry1993，268，24： | 1 |
| 7 | 5-epi-deoxyrhamnojirimycin is a potent inhibitor of an α-L-rhamnosidase:5-epi-deoxymannojirimycin is not a potent inhibitor of an α-D-mannosidase显示文摘 | Davis B G Hull A Smith C | 1998 | Tetrahedron:Asymmetry1998，9，： | 1 |
| 8 | Hexachlorobenzene in hazardous waste sites显示文摘 | DAVIS B D MORGAN R C | 1986 | IARC Sci Publ1986，77，： | 1 |
| 9 | Elastin is an essential determinant of arterial morphogenesis显示文摘 | D Y Li B Brooke E C Davis | 1998 | Nature1998，393，21： | 1 |
| 10 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 11 | X-ray interactions: photoabsorption scattering, transmission and reflection at E=50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，： | 1 |
| 12 | Long-term carbon dioxide fluxes from a very tall tower in a northern forest:flux measurement method,ology显示文摘 | BERGER B W DAVIS K J YI C | 2001 | Atmos Ocean Technol2001，18，： | 1 |
| 13 | Commutation Failures in HVDC Transmission Systems显示文摘 | THIO C V DAVIES J B KENT K L | | 0，，02： | 1 |
| 14 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 15 | Chromium oligopeptide activates insulin receptor tyrosin kinase activity 显示文摘 | Davis C M Vincent J B | 1997 | Biochem1997，36，15： | 1 |
| 16 | Pneumocystis colonisation is common among hospitalised HIV infected patients with nonpneumocystis pneumonia显示文摘 | Davis J L Welsh D A Beard C B | 2008 | Thorax2008，63，4： | 1 |
| 17 | The temperature of Europe during the Holoeene reconstructed from pollen data显示文摘 | Davis B A S Brewer S Stevenson A C | 2003 | Quaternary Science Reviews2003，22，1517： | 1 |
| 18 | Commutation failures in HVDC transmission systems显示文摘 | Thio C V Davies J B Kent K L | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 19 | X-ray interaction:photoabsorption,scattering,transmission and reflection at E=50-30000eV,Z=1-92显示文摘 | HENKE B L GULLIKSEN E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 20 | Review of fish swimming modes for aquatic locomotion显示文摘 | SFAKIOTAKIS M LANE D M DAVIES J B C | 1999 | IEEE Journal of Oceanic Engineering1999，24，2： | 1 |
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