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| 1 | Current medical treatment of estrogen receptor-positive breast cancer显示文摘Approximately 80% of breast cancers(BC) are estrogen receptor(ER)-positive and thus endocrine therapy(ET) should be considered complementary to surgery in the majority of patients. The advantages of oophorectomy, adrenalectomy and hypophysectomy in women with advanced BC have been demonstrated many years ago, and currently ET consist of(1) ovarian function suppression(OFS), usually obtained using gonadotropinreleasing hormone agonists(Gn RHa);(2) selective estrogen receptor modulators or down-regulators(SERMs or SERDs); and(3) aromatase inhibitors(AIs), or a combination of two or more drugs. For patients aged less than 50 years and ER+ BC, there is no conclusive evidence that the combination of OFS and SERMs(i.e., tamoxifen) or chemotherapy is superior to OFS alone. Tamoxifen users exhibit a reduced risk of BC, both invasive and in situ, especially during the first 5 years of therapy, and extending the treatment to 10 years further reduced the risk of recurrences. SERDs(i.e., fulvestrant) are especially useful in the neoadjuvant treatment of advanced BC, alone or in combination with either cytotoxic agents or AIs. There are two types of AIs: type Ⅰ are permanent steroidal inhibitors of aromatase, while type Ⅱ are reversible nonsteroidal inhibitors. Several studies demonstrated the superiority of the third-generation AIs(i.e., anastrozole and letrozole) compared with tamoxifen, and adjuvant therapy with AIs reduces the recurrence risk especially in patients with advanced BC. Unfortunately, some cancers are or became ET-resistant, and thus other drugs have been suggested in combination with SERMs or AIs, including cyclin-dependent kinase 4/6 inhibitors(palbociclib) and mammalian target of rapamycin(m TOR) inhibitors, such as everolimus. Further studies are required to confirm their real usefulness. | Franco Lumachi Davide A Santeufemia Stefano MM Basso | 2015 | World Journal of Biological Chemistry2015，6，3： | 16 |
| 2 | Modulators of neuronal cell death in epilepsy显示文摘 | David CH Brona MM | 2008 | Neurosciences2008，8，1： | 1 |
| 3 | The epidemiology of sepsis in the United States from 1979 through 2000 显示文摘 | GREG SM DAVID MM STEPHANIE E | 2003 | N Engl J Med2003，348，16： | 1 |
| 4 | Renin- angiotensin Ⅱ response to the hemodynamic pathology of ovines with ventricular septal defect显示文摘 | Bouceck MM Richard C David PS | 1989 | Circ Res1989，64，3： | 1 |
| 5 | Determination of serum proteins by means of the biuret reaction显示文摘 | Gomall AG Bardawill CJ David MM | 1949 | Journalof Biological Chemistry1949，177，2： | 1 |
| 6 | Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors 显示文摘 | Michael MM David CH | 1992 | Cancer1992，69，9： | 1 |
| 7 | Trends in hospitalizations for AIDS-associated Pneumocystis jirovecii pneumonia in the United States (1986 to 2005) 显示文摘 | Colleen FK William C David MM | 2009 | Chest2009，136，1： | 1 |
| 8 | Human papillomavirus- like particles mediate functional delivery of plasmid DNA to aotigen presenting cells in vivo显示文摘 | Christine MM David AS Young-Eun EL | 2007 | Vaccine2007，25，： | 1 |
| 9 | Fleischner society : glossary of terms for thoracic imaging显示文摘 | David MH Alexander AB Heber MM | 2008 | Radiology2008，3，246： | 1 |
| 10 | Injectable micro-bubbles as contrast agents for diagnostic ultrasound imaging:The key role of perfluorochemicals显示文摘 | Ernest GS David HK Robert MM | 2003 | Angew Chem Int Engl2003，42，： | 1 |
| 11 | Medical Mal- practice 显示文摘 | David MS Michelle MM Troyen AB | 2004 | The New England Journal of Medicine2004，350，3： | 1 |
| 12 | Efficiency of pulse dye therapy for the treatment of ulcerated haemangiomas:a review of 78 patients显示文摘 | David LR Malek MM Argenta LC | 2003 | Br J Plast Surg2003，56，4： | 1 |
| 13 | Anatomical study of sesamoid bones of the first metatarsa显示文摘 | David RD Delagoutte JP Renard MM | 1989 | J-Am-Podiatr-Med-Amoc1989，79，11： | 1 |
| 14 | Consensus-degenerate hybrid oligonucleotide primers (CODEHOP) for the detection of novel papillomaviruses and their application to esophageal and tonsillar carcinomas显示文摘 | Jonathan EB Renee MM David P | 2004 | J Virol Methods2004，，： | 1 |
| 15 | Efficacy of pulse dye laser therapy for the treatment of ulcerated haemangiomas: a review of 78 patients 显示文摘 | David LR Malek MM Argenta LC | 2003 | Br J Plast Surg2003，56，4： | 1 |
| 16 | Physical evidence of McsS,a QTL controlling mammary carcinoma susceptibility,in congenic rats显示文摘 | Jill DH Hong L Dinelli MM Millicent AS Bradley DK Michael NG | 2003 | Carcinogenesis2003，24，9： | 1 |
| 17 | Improvement of growth of Chlamydia pneumoniae on Hep 2 ceils by pretreatment with polyethylene glycol in combination with additional centrifugation and extension of culture time 显示文摘 | TjhieJH Robert R David MM | 1997 | J Clinic Microbiol1997，35，7： | 1 |
| 18 | An ex vivo biomechanical evalution of an inflatable bone tamp used in the treatment of compression fracture显示文摘 | John MM David CF | 2001 | Spine2001，26，： | 1 |
| 19 | Determination of serum proteins by means of biuret reaction 显示文摘 | Gornall AG Bordawilla CJ David MM | 1949 | J Biol Chem1949，177，： | 1 |
| 20 | Physical activity, sedentary behaviors, physical fitness, and their relation to health outcomes in youth with type 1 and type 2 diabetes : A review of the epidemio- logic literature显示文摘 | Angela DL Ma XG David MM | 2013 | J Sport Health Sci2013，16，2： | 1 |
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