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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Intracerebral haemorrhage显示文摘 | Adnan I Qureshi A David Mendelow Daniel F Hanley | 2009 | The Lancet . 2009 (9675)2009，，9675： | 3 |
| 3 | Immunohistoehemical analysis of ras oncogene p21 product in human gastric carcinomas and their adjacent mucosa显示文摘 | Carneiro F David I Sunkel C | 1992 | Pathol Res Praet1992，188，1： | 2 |
| 4 | Ramsdellite-MnO2 for lithium batteries: The ramsdellite to spinel transformation显示文摘 | THACKERAY M M ROSSOUW M H GUMMOW R J LILES D C PEARCE K KOCK A D DAVID W I F HULLS S | 1993 | Electrochim Acta1993，38，9： | 1 |
| 5 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 6 | Lithium insertion into manganese spinels 显示文摘 | Thackeray M M David W I F Bruce P G | 1983 | Mater Res Bull1983，18，4： | 1 |
| 7 | 显示文摘 | Ismail A F David L I B | 2001 | J Membr Sci2001，193，1： | 1 |
| 8 | 显示文摘 | David W I F Jones M O | 2007 | J Am Chem Soc2007，129，： | 1 |
| 9 | Animal models of attention-deficit hyperactivity disorder 显示文摘 | Davids E Zhang K Tarazi F I | 2003 | Brain Res Brain Res Rev2003，42，1： | 1 |
| 10 | Lithium insertion into manganese spinels显示文摘 | Thackeray M M David W I F Bruce P G | 1983 | Materials Research Bulletin1983，18，4： | 1 |
| 11 | Structure determination from powder diffraction data 显示文摘 | David W I F Shankland K | 2008 | Acta Cryst A2008，64，： | 1 |
| 12 | Synthesis and Structural Characterization of the Normal Spinel Li O4显示文摘 | Thomas M G S R David W I F Goodenough J B | 1985 | Mater Res Bull1985，20，： | 1 |
| 13 | Lithium Insertion into Manganese Spinels显示文摘 | Thackeray M M David W I F Bruce P G | 1983 | Mater Res Bull1983，18，： | 1 |
| 14 | Serotonin transporter binding increases in caudate-putamen and nucleus accumbens after neonatal 6-hydroxydopamine lesions in rats: implications for motor hyperactivity显示文摘 | ZHANG K DAVIDS E TARAZI F I | 2002 | Dev Brain Res2002，137，2： | 1 |
| 15 | No evidence for an ischemic penumbra in massive experimental intracerebral hemorrhage显示文摘 | Adnan I David A Danial F | 1999 | Neurology1999，52，2： | 1 |
| 16 | Molecular Structure of the Fulleride Anions in Superconducting K3C60 and Insulating K6C60 Determined by Power Neutron Diffraction显示文摘 | Allen K M David W I F Fox J M | 1995 | Chem Mater1995，7，： | 1 |
| 17 | High-temperature lithiati on of α-Fe2 O3: a mechanistic study显示文摘 | Thackeray M M David W I F Goodenough J B | 1984 | J Solid State Chem1984，55，： | 1 |
| 18 | Structural characterization of the lithium ion oxides LixFe3 O4 and Lix Fe2O3 (0显示文摘 | Thackeray M M David W I F Goodenough J B | 1982 | Mat Res Bull1982，17，： | 1 |
| 19 | Design of a PZT Bimorph Actuator Using a meta - model based Approach 显示文摘 | DAVID J C MARY I F TIMOTHY W S | 2002 | Transactions of the ASME2002，124，6： | 1 |
| 20 | Plant anticancer agents:new bisindole alkaloids from Tabernaemontana johnstonii stem bark显示文摘 | David G I Kingston B B Gerhart F I | 1978 | J pharm sci1978，67，2： | 1 |
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