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| 1 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 2 | AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants显示文摘AtbHLH29 of Arabidopsis, encoding a bHLH protein, reveals a high similarity to the tomato FER which is proposed as a transcriptional regulator involved in controlling the iron deficiency responses and the iron uptake in tomato. For identification of its biological functions, AtbHLH29 was introduced into the genome of the tomato FER mutant T3238fer mediated by Agrobacterium tumefaciencs. Transgenic plants were regenerated and the stable integration of AtbHLH29 into their genomes was confirmed by Southern hybridization. Molecular analysis demonstrated that expression of the exogenous AtbHLH29 of Arabidopsis in roots of the FER mutant T3238fer enabled to complement the defect functions of FER. The transgenic plants regained the ability to activate the whole iron deficiency responses and showed normal growth as the wild type under iron-limiting stress. Our transformation data demonstrate that AtbHLH29 is a functional ortholog of the tomato FER and can completely replace FER in controlling the effective iron acquisition in tomato. Except of iron, FER protein was directly or indirectly involved in manganese homeostasis due to that loss functions of FER in T3238fer resulted in strong reduction of Mn content in leaves and the defect function on Mn accumulation in leaves was complemented by expression of AtbHLH29 in the transgenic plants. Identification of the similar biological functions of FER and AtbHLH29, which isolated from two systematically wide-diverged “strategy I” plants, suggests that FER might be a universal gene presented in all strategy I plants in controlling effective iron acquisition system in roots. | You Xi YUAN Juan ZHANG Dao Wen WANG Hong Qing LING | 2005 | Cell Research2005，15，8： | 22 |
| 3 | 黄芪多糖对丝裂霉素C(MMC)致骨髓抑制小鼠骨髓及脾脏造血祖细胞的生成作用的影响显示文摘目的 研究黄芪多糖 (APS)对MMC致骨髓抑制小鼠的骨髓和脾造血祖细胞生长的影响。方法 d 0腹腔注射丝裂霉素C(MMC) 7mg·kg- 1 ,APS皮下注射 1 0 0mg·kg- 1·d- 1 ,给药方案分 3种 :① 0~ 4d ,共 5d ;② 0~ 1 1d ,共 1 2d ;③ 1 2d给药 ,3wk内给完 ,用造血细胞集落培养法观察APS的药理作用。结果 在d 3时 ,APS治疗组对MMC致骨髓抑制小鼠骨髓CFU C数目增加了 3倍 ,分别为 1 870±40 /股骨和 62 4 0± 1 1 0 /股骨 ,从d 3~d 1 8,APS治疗组的骨髓CFU C均高于模型组。在给MMC后d 1 4之前APS对脾CFU C的生长没有影响 ,APS在d 1 4和d 1 8时APS有刺激脾造血祖细胞增殖作用 (分别高 3倍和 2倍 )。 | 夏星 Dao Nguyen | 2003 | 中国药理学通报2003，19，7： | 20 |
| 4 | The Frattini Subalgebra of Restricted Lie Superalgebras显示文摘在现在的论文,我们学习限制谎言 superalgebra 的 Frattini subalgebra (L,[p ]) 。我们首先看那是否 L = A 1 鈯? A 2 鈯?鈯? A n 一,然后? p (L)=? p (一 1 )+? p (一 2 )+?+? p ( n ),在每 A i 是 L 的 p 鈥搃d eal 的地方。我们然后获得二结果:F (L)=?(L)= J (L)= L (1 ) 如果并且仅当 L 是 nilpotent;如果 L 是可解决的, F p (L) 和 F (L) 是 L 的 nilpotent 理想。另外,必要、足够的条件被作出对有利的裁决 ? p 鈥揻r ee 限制了谎言 superalgebras。最后,我们讨论 E 鈥損鈥搑e stricted 谎言 superalgebras 和 E 鈥搑e stricted 谎言 superalgebras 的关系。关键词限制了谎言 superalgebras - E 鈥損鈥搑e stricted 谎言 superalgebras - Frattini p 鈥搒u balgebra -蠁 p 鈥揻r ee - p 鈥揺l ementary 先生(2000 ) 题目分类 17B40 - 17B50 由中国(资助号码 10271076 ) | Liang Yun CHEN Dao Ji MENG Yong Zheng ZHANG | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 18 |
| 5 | Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19显示文摘In December 2019,an outbreak of novel coronavirus(2019-nCoV)occurred in Wuhan,Hubei Province,China.By February 14,2020,it has led to 66492 confirmed patients in China and high mortality up to^2.96%(1123/37914)in Wuhan.Here we report the first family case of coronavirus disease 2019(COVID-19)confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid(SHL).This report describes the identification,diagnosis,clinical course,and management of three cases from a family,suggests the expected therapeutic effects of SHL on COVID-19,and warrants further clinical trials. | Li Ni Ling Zhou Min Zhou Jianping Zhao Dao Wen Wang | 2020 | Frontiers of Medicine2020，14，2： | 15 |
| 6 | Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis显示文摘Dear Editor,Patients presenting with acute myocarditis and sudden hemodynamic instability (termed fulminant myocarditis [FM]) still have a high mortality and need for heart transplantation, up to 28% at 60 days.1,2,3 Recent scientific statements and expert opinion consensus suggests early use of temporary mechanical circulatory supports (t-MCS).3,4 Specifically, Chinese scientific statement proposed an extensive use of t-MCS combined with immunoregulatory therapy (IT),4 although formal trials are lacking. We present a multicenter, retrospective study to compare the outcome of patients who were treated with t-MCS and IT vs. patients who didn’t receive these treatments. We included patients with the diagnosis of FM based on the presence of viral prodromal signs/symptoms followed by acute onset of severe heart failure (HF) without other relevant differential diagnosis or pre-existing cardiac disorders. Patients who received both t-MCS and IT during hospitalization were classified as t-MCS+IT group. | Ning Zhou Yuhua Zhao Jiangang Jiang Lan Shen Junming Li Jing Wan Xueping Ma Jing Zhang Enrico Ammirati Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 14 |
| 7 | Efficacy of intra- tumor injection of Kang-Lai-Te in treating transplanted hepatoma in rats显示文摘BACKGROUND: Non-operative therapy takes an impor- tant position in comprehensive therapy of liver cancer. De- spite some effects by using ethanol, acetic acid and heat sa- line for intra-tumor injection in the treatment of liver canc- er, it is difficult to attain a complete cure but bring about injury to the liver to some extent. Hence, searching for other drugs for the local treatment of liver tumor is an im- portant option. This study was designed to set up rat mo- dels of transplanted liver cancer, intra-tumor injection of Kang-Lai-Te (KLT), and negative control (saline) and positive control (ethanol). The effect of intra-tumor injec- tion of KLT in treating transplanted hepatoma in rats and its advantages and disadvantages were assessed and the pos- sibility of its use in treating patients with liver cancer was evaluated. METHODS: Forty rats were divided into 4 groups ( G1, G2, G3 and G4, 10 rats in each group). Different drugs were injected into their implanted hepatoma (G1 with 0.2 ml saline as control, G2 with 10 mg KLT, G3 with 20 mg KLT, G4 with 0.2 ml ethanol). After 3 and 8 days, the hepa- toma volume (HV), the serum levels of albumin, alanine aminotransferase(ALT), aspartate aminotransferase alkaline phosphatase( ALP) and creatinine, as well as the expression of proliferation cell nuclear antigen (PCNA) in hepatoma were detected. RESULTS: After 3 days, the HVs were smaller in G3 and G4 than in G1 (P <0.05), the serum levels of albumin were higher in G2 and G3 than in Gl and G4 (P <0.05), the se- rum levels of ALT and AST were lower in G2 and G3 than in G4 (P<0.05), the serum levels of ALP was lower in G2 and G3 than in Gl and G4 (P <0. 05), the PCNA labeling indexes (PCNA LI) were lower in G2 and G3 than in Gl and GA (P <0.05). After 8 days, the HVs were smaller in G2, G3 and G4 than in Gl (P <0.05), and the differences of HVs among G2, G3 and G4 were not significant. The serum levels of ALP were lower in G1, G2 and G3 than in G4 (P <0.05), and the PCNA LI were lower in G3 than in Gl andG4 (P<0.05). CONCLUSION: Intra-tumor injection of KLT into implan- ted hepatoma is evidently effective, but it is less effective than ethanol. The effect of KLT on liver function is markedly lower than that of ethanol. | Li-Qun Wu, Yun Lu, Hua-Jun Lu, Zong-Gang Zhao and Meng Yang Qingdao, China Department of Hepato-biliary-vascular Surgery, Qing- dao University Medical College, Qingdao 266003 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，4： | 12 |
| 8 | Status and distribution changes of the endangered Green Peafowl (Pavo muticus) in China over the past three decades (1990s-2017)显示文摘Background: Understanding the changes in population dynamics, including demographics, distribution and threats, is essential for species status assessing. The endangered Green Peafowl(Pavo muticus) has experienced sharp population declines and distribution range diminishing both in China and Southeast Asia. Field population surveys have not been conducted in China since the 1990 s, which hindered conservation planning and decision-making.Methods: With interview and line transects methods, we figured out the population and distribution changes of Green Peafowl across its historical ranges over the past three decades in China during 2014-2017.Results: The Green Peafowl once habituated in 54 counties in China. Nearly 60% of the distribution counties were lost in the past three decades, with the left 22 counties distributed in central, southern and western Yunnan, SW China. Population decrease detected in all distribution areas except for Shuangbai and Xinping county where more than 60% of the total population is located. Only about 30% of the former bird population were recorded with the same interviewing method as 20 years ago. Three birds, 1 carcass, 6 calls and 12 footprints were detected along the 865 km line transects, indic-ating extremely low encounter rate of Green Peafowl in field. Sharp decreases in flock sizes were also detected, from 820 birds per flock in the 1990 s to 3-5 birds at present. Poaching and habitat conversion are two widespread and long-lasting threats, while poisoning caused mortality in the past and hydropower construction affect regional population's survival. Large flocks of 18–27 birds were discovered in the field, which increases our confidence of population recovery of this endangered pheasant in China.Conclusions: Only interviewed bird number and counts based on line transects were presented in this study, without further population estimation due to limitation of the data sets. Although the actual population of this cryptic bird must be underestimated, dramatic population declines and distribution concentrations of the endangered Green Peafowl occurred over the past 30 years in China undoubtedly. | Dejun Kong Fei Wu Pengfei Shan Jianyun Gao Dao Yan Weixiong Luo Xiaojun Yang | 2018 | Avian Research2018，9，2： | 12 |
| 9 | CeCl_3·7H_2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction显示文摘Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure. | Yan Dai Chun Xu Lü | 2010 | Chinese Chemical Letters2010，21，1： | 10 |
| 10 | 间伐对杨树人工林土壤微生物量和氮含量的影响显示文摘针对生产中杨树大径材培育存在的问题,设计了4种间伐处理(对照、30%下层伐、50%下层伐和50%机械伐),研究了不同间伐处理对杨树人工林土壤微生物量碳、微生物量氮、土壤无机氮和土壤溶解性有机氮含量的影响及其时间和空间格局。结果表明,由于间伐处理改变了林地土壤的温度和水分条件,导致在生长季高强度间伐处理(50%下层伐和50%机械伐)显著提高了土壤微生物量碳和微生物量氮含量,表现为50%机械伐>50%下层伐>30%下层伐>不间伐,而在非生长季则表现相反的趋势。高强度间伐显著提高了土壤无机氮含量,但50%下层伐和50%机械伐的土壤无机氮含量差异不显著;土壤无机氮(NH_4^+-N和NO_3^--N)主要以硝态氮的形式存在,并表现出明显的季节动态。高强度间伐提高了土壤溶解性有机氮含量,特别在夏季和秋季这种差异达到显著水平。从不同土壤层次看,土壤微生物量、土壤无机氮和溶解性有机氮均表现出明显的表聚性。研究结果可为杨树人工林的可持续经营提供理论依据和技术支撑。 | 林达 DAO Ngoc Chuong 洪森先 田野 方升佐 | 2016 | 森林与环境学报2016，36，4： | 10 |
| 11 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 12 | Temporal echocardiography findings in patients with fulminant myocarditis: beyond ejection fraction decline显示文摘The features of myocardial strains from speckle-tracking echocardiography (STE) have not been well defined in fulminant myocarditis (FM) patients.In this study,changes in the left ventricular ejection fraction (LVEF) and global and layer-specific myocardial strains over time were monitored.We aimed to determine the echocardiographic patterns of FM and ascertain their significance in FM treatment.Twenty patients who were clinically diagnosed with FM and received mechanical life support were prospectively enrolled.Conventional echocardiographic measurements were obtained,and serial strain echocardiography was performed from admission to hospital discharge until LVEF recovery (> 50%).Global/regional peak systolic longitudinal strains (GLS/RLS) and layer-specific longitudinal strains were quantified,and their changes with time were monitored in 14 FM patients.All patients had severely impaired cardiac function.Steep improvement in LVEF and GLS were observed within 6 days.Layer-specific strain analysis showed that reduction at admission or recovery at discharge in the endocardium and epicardium strains were equal.In conclusion,FM patients who received mechanical circulatory supports exhibited steep improvement in ventricular function within 6 days.The patchy and diffused distribution pattern of reduced RLS and equally and severely impaired strain in the endocardium and epicardium are valuable features in the diagnosis of FM. | Houjuan Zuo Rui Li Fei Ma Jiangang Jiang Kun Miao Haojie Li Eike Nagel Marijana Tadic Hong Wang Dao Wen Wang | 2020 | Frontiers of Medicine2020，14，3： | 10 |
| 13 | The Frattini Subalgebra of n-Lie Algebras显示文摘在这篇论文,我们主要学习 n 躺着代数学的 Frattini subalgebraand Jacobson 基的结构的观点。在 Frattini 潜水艇代数学和 Jacobson 基之间的 Frattini 潜水艇代数学和关系上的性质被学习。而且,当 n 躺着代数学是强壮的时,我们也学习他们半简单,可解决的κ - 和无有势力。 | Rui Pu BAI Liang Yun CHEN Dao Ji MENG | 2007 | Acta Mathematica Sinica,English Series2007，23，5： | 10 |
| 14 | Behavior of noncircular tunnels excavated in stratified rock masses-Case of underground coal mines显示文摘The amount of tunnels excavated along stratified/sedimentary rock masses in Quangninh coal mine area,Vietnam, is gradually increasing. Rock mass in Quangninh is characterized by beddings between rock layers. The behavior of stratified rock masses surrounding the tunnels depends on both the intact rock and the beddings between rock layers. The main characteristics of stratified rock masses that need to be considered are their heterogeneity and anisotropy. Depending on the dip angle of rock layers, movements and failure zones developed surrounding the tunnels can be asymmetrical over the vertical axis of tunnel. This asymmetry causes adverse behaviors of the tunnel structures. The objective of this study is to highlight convergences and yielded zones developed in rock masses surrounding noncircular tunnels in Quangninh coal mine area using a finite element method. The presence of bedding joints is explicitly simulated. The numerical results indicated that with the increase in dip angle of bedding joints, the stress asymmetry over the tunnel vertical axis increases. It gradually leads to an asymmetry of the failure zone surrounding the tunnel. An increase of rock mass quality means a decrease of rock mass sensitivity to the discontinuities. In addition,a dip angle of the bedding joints of approximately 45° could be considered as the critical angle at which the rock mass mechanism changes between sliding and bending. | Ngoc Anh Do Daniel Dias Van Diep Dinh Tien Tung Tran Van Canh Dao Viet Doan Dao Phuc Nhan Nguyen | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，1： | 9 |
| 15 | Role of trivalent antimony in the removal of As, Sb, and Bi impurities from copper electrolytes显示文摘The role of trivalent antimony was investigated in removing As, Sb, and Bi impurities from a copper electrolyte. Purification experiments were carried out by adding a various concentrations of Sb(Ⅲ) ions in a synthetic electrolyte containing 185 g/L sulfuric acid, 45 g/L Cu2+, 10 g/L As, and 0.5 g/L Bi under stirring at 65°C for 2 h. The electrolyte was filtered, and the structure, morphology and composition of the precipitate were analyzed by means of chemical analysis, scanning electron microscopy (SEM), X-ray diffraction (XRD), transmission electron microscopy (TEM), and IR spectroscopy. The precipitate is composed of irregular lumps which are agglomerated by fine dendritic and floccus particles, and it mainly consists of As, Sb, Bi, and O elements. Characteristic bands in the IR spectra of the precipitate are As-OX (X=As, Sb, Bi), Sb-OY (Y=Sb, Bi), O-As-O, As-OH, Sb-OH, and O-H. The precipitate is a mixture of microcrystalline SbAsO4, (Sb,As)2O3, and amorphous phases. As, Sb, and Bi impurities are effectively removed from the copper electrolyte by Sb(Ⅲ) ions attributing to these precipitates. | Fa-xin Xiao Dao Cao Jian-wei Mao Xiao-ni Shen Feng-zhang Ren | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，1： | 9 |
| 16 | Multigene phylogeny of the family Cordycipitaceae (Hypocreales): new taxa and the new systematic position of the Chinese cordycipitoid fungus Paecilomyces hepiali显示文摘The phylogeny and systematics of cordycipitoid fungi have been extensively studied in the last two decades.However,systematic positions of some taxa in the family Cordycipitaceae have not yet been thoroughly resolved.In this study,a new phylogenetic framework of Cordycipitaceae is reconstructed using multigene(nrSSU,nrLSU,tef-1α,rpb1 and rpb2)sequence data with large-scale taxon sampling.In addition,ITS sequence data of species belonging to the Lecanicillium lineage in the family Cordycipitaceae are used to further determine their phylogenetic placements.Based on molecular phylogenetic data together with morphological evidence,two new genera(Flavocillium and Liangia),16 new species and four new combina-tions are introduced.In the new genus Flavocillium,one new species F.bifurcatum and three new combinations previously described as Lecanicillium,namely F.acerosium,F.primulinium and F.subprimulinium,are proposed.The genus Liangia is built by the new species Lia.sinensis with Lecanicillium-like asexual morph,isolated from an entomopathogenic fungus Beauveria yunnanensis.Due to the absence of Paecilomyces hepiali,an economically and medically significant fungus,in the earlier phylogenetic analyses,its systematic position has been puzzling in both business and academic communities for a long time.Here,P.hepiali is recharacterized using the holotype material along with seven additional samples.It is assigned to the genus Samsoniella(Cordycipitaceae,Hypocreales)possessing Cordyceps-like sexual morph and Isaria-like asexual morph,and thus a new combination,namely S.hepiali is proposed.An additional nine new species in Samsoniella are described:S.alpina,S.antleroides,S.cardinalis,S.cristata,S.lanmaoa,S.kunmingensis,S.ramosa,S.tortricidae and S.yunnanensis.Four new species in Cordyceps are described:C.chaetoclavata,C.cocoonihabita,C.shuifuensis and C.sub-tenuipes.Simplicillium yunnanense,isolated from synnemata of Akanthomyces waltergamsii,is described as a new species. | Yuan-Bing Wang Yao Wang Qi Fan Dong-E Duan Guo-Dong Zhang Ru-Qin Dai Yong-Dong Dai Wen-Bo Zeng Zi-Hong Chen Dan-Dan Li De-Xiang Tang Zhi-Hong Xu Tao Sun Thi-Tra Nguyen Ngoc-Lan Tran Van-Minh Dao Can-Ming Zhang Luo-Dong Huang Yong-Jun Liu Xiao-Mei Zhang Da-Rong Yang Tatiana Sanjuan Xing-Zhong Liu Zhu L.Yang Hong Yu | 2020 | Fungal Diversity2020，，4： | 9 |
| 17 | Serological prevalence and risk factor analysis of hepatitis G virus infection in Hubei Province of China显示文摘INTRODUCTIONHepatitis G virus(HGV),also known as GB virus C,is arecently cloned virus which may be associated with humannon A-E hepatitis.It is parenterally transmitted andusually coinfected or superinfected with hepatitis B orhepatitis C virus.Some investigations have | De Ying Tian Dao Feng Yang Ning Shao Xia Zheng Gang Zhang Hong Bo Lei Yuan Cheng Huang | 2000 | World Journal of Gastroenterology2000，6，4： | 8 |
| 18 | Fulminant myocarditis:a comprehensive review from etiology to treatments and outcomes显示文摘Fulminant myocarditis(FM)is characterized by a rapid progressive decline in cardiac function and a high mortality rate.Since the first report of FM patients in the 1980s,several clinical trials and research studies have been published increasing our knowledge regarding FM.Currently,the diagnosis of FM depends on various techniques including electrocardiography,echocardiography,endomyocardial biopsy,and cardiac magnetic resonance.The development of mechanical circulation support(MCS)devices and progress in our understanding of the pathophysiological mechanisms underlying FM,treatment regimens have evolved from simple symptomatic treatment to a life support-based comprehensive treatment approach.The core mechanism underlying the development of FM is the occurrence of an inflammatory cytokine storm.This review provides a comprehensive account of the current understanding of FM pathophysiology and knowledge regarding its etiology,pathophysiology,treatments,and outcomes. | Weijian Hang Chen Chen John M.Seubert Dao Wen Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 19 | 离子固化剂改性蒙脱土吸附水特性及持水模型研究显示文摘采用不同浓度离子固化剂对天然钙蒙脱土进行改性处理,开展素土与改性土在相对湿度(P/P0)0.01~0.95区间的水汽等温吸—脱附试验,通过持水速率曲线、晶层d001演化曲线及红外光谱特征峰解析蒙脱土吸附水进程中主控因素的演化规律,据此提出水合状态变化的界限相对湿度区间,在此基础上,分别从阳离子水化能和晶层表面水合能角度,建立了离子固化剂改性蒙脱土微观持水方程。试验结果表明:对于钙蒙脱土,在0 200 MPa),蒙脱土持水能力只受控于层间阳离子水化作用,而在中高吸力段(15 MPa<ψ<200 MPa),晶层基面与水之间的分子作用力是影响蒙脱土表面水合能及持水性状的主要因素。在特定吸力范围内,离子固化剂通过改变相应的物化性质参数(阳离子交换量、比表面积)从而弱化蒙脱土持水能力。基于微观水合机制所构建的持水方程能够很好预测本次试验及文献报道的数据结果,不同吸力段的持水模型可量化表征离子固化剂对蒙脱土吸附水性状的调控机理。 | 黄伟 刘清秉 项伟 张云龙 王臻华 DAO Minh Huan | 2019 | 岩土工程学报2019，41，1： | 8 |
| 20 | Floor heave characteristics and control technology of the roadway driven in deep inclined-strata显示文摘Based on in-mine instrumentation and theoretical analysis of the unsymmetrical large-deformation that occurred in the roadway after excavation,Differential Floor Heave(DFH)was found to be the main reason for roadway failure.It needs to be pointed out that the specific roadway was driven in inclined rock strata.In addition,the factors that contribute to the occurrence of DFH are discussed in detail.It is believed that DFH is triggered by the unsymmetrical stress distribution in the floor and the different rock types encountered near the two floor corners.Hence,DFH control should be focused on the left floor corner where shearing failure occurs initially and the left floor surface where tensile failure is more severe.The proposed DFH control strategies include unsymmetrical grouting for the whole roadway,re-design of the roof and ribs support,reinforcement of the weak zones,and release of the concentrated stress in the earlier stage.Meanwhile,it is recommended that in the later stage,both bolts and cable bolts with higher strength and the backfilling technique using the coal measure rocks and concrete should be employed in the reversed-arch floor.The field instrumentation results,after using the proposed control strategies,indicate that large deformation in a DFH roadway has been successfully controlled. | Wang Meng Guo Guanlong Wang Xiangyu Guo Yu Dao Vietdoan | 2015 | International Journal of Mining Science and Technology2015，25，2： | 7 |
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