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| 1 | 术后活动性疼痛护理评估对疼痛管理质量的影响显示文摘目的探讨术后活动性疼痛护理评估对疼痛管理质量的影响。方法将140例胸腹部术后1d的患者分为实验组和对照组。实验组在接受病区护士的术后疼痛护理措施的基础上,由疼痛专科护士采用功能活动评分法(Functional Activity Score,FAS)和数字评定量表(Numerical Rating Scale,NRS)评估活动性疼痛,并根据评估结果实施干预措施。对照组仅接受病区护士实施的术后疼痛护理措施。结果实验组和对照组术后24h内镇痛治疗方案调整及功能活动前按压镇痛泵比例的差异具有统计学意义(χ2=7.937,χ2=37.303,均P<0.05)。实验组在术后24h时间点的FAS评级结果、患者自评静息性和活动性疼痛强度,以及术后24h内疼痛最剧烈程度、中重度疼痛发生频度及有效咳嗽受疼痛影响程度均低于对照组(P<0.05),首次下床活动时间也早于对照组(P<0.05)。结论开展活动性疼痛护理评估实践有助于提高术后疼痛管理质量。 | 成燕 童莺歌 刘敏君 田素明 Alex H.Konstantatos Dana Boyd | 2015 | 中华护理杂志2015，50，8： | 161 |
| 2 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 3 | The International Agency for Research on Cancer(IARC) evaluation of the carcinogenicity of outdoor air pollution:focus on China显示文摘The International Agency for Research on Cancer(IARC)has classified outdoor air pollution and the particulate matter(PM)in outdoor air pollution as carcinogenic to humans,as based on sufficient evidence of carcinogenicity in humans and experimental animals and strong support by mechanistic studies.The data with important contributions to the evaluation are reviewed,highlighting the data with particular relevance to China,and implications of the evaluation with respect to China are discussed.The air pollution levels in Chinese cities are among the highest observed in the world today and frequently exceed healthbased national and international guidelines.Data from high-quality epidemiologic studies in Asia,Europe,and North America consistently show positive associations between lung cancer and PM exposure and other indicators of air pollution,which persist after adjustment for important lung cancer risk factors,such as tobacco smoking.Epidemiologic data from China are limited but nevertheless indicate an increased risk of lung cancer associated with several air pollutants.Excess cancer risk is also observed in experimental animals exposed to polluted outdoor air or extracted PM.The exposure of several species to outdoor air pollution is associated with markers of genetic damage that have been linked to increased cancer risk in humans.Numerous studies from China,especially genetic biomarker studies in exposed populations,support that the polluted air in China is genotoxic and carcinogenic to humans.The evaluation by IARC indicates both the need for further research into the cancer risks associated with exposure to air pollution in China and the urgent need to act to reduce exposure to the population. | Dana Loomis Wei Huang Guosheng Che | 2014 | Chinese Journal of Cancer2014，33，4： | 37 |
| 4 | Diabetes mellitus related bone metabolism and periodontal disease显示文摘Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide.Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus.Alveolar bone loss is one of the main outcomes of periodontitis,and diabetes is among the primary risk factors for periodontal disease.In this review,we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects,focusing on alveolar bone loss.Bone remodelling begins with osteoclasts resorbing bone,followed by new bone formation by osteoblasts in the resorption lacunae.Therefore,we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts. | Ying-Ying Wu E Xiao Dana T Graves | 2015 | International Journal of Oral Science2015，7，2： | 30 |
| 5 | 武汉市区第四系含水层地下水有机污染敏感性研究显示文摘在详细调查武汉市水文地质条件和地下水污染现状的基础上 ,获得了高精度的武汉市水环境中微量有机污染物的组成数据 .所检测出的有机组分达 3 0余种 ,以苯及相关苯系物为主 ,污染程度较高的地下水主要分布在人口密集区和工业、商业区 .应用改进的DRASTIC模型———地下水污染敏感性评价模型 ,在GIS平台上 ,编制了武汉市区地下水污染敏感性分区图 .根据其评价结果 ,建议集中对那些敏感性相对较高的区域采取有效的环保措施 。 | 王焰新 李义连 付素蓉 蔡鹤生 Broder Merkel Dana Ihm | 2002 | 地球科学(中国地质大学学报)2002，27，5： | 27 |
| 6 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 7 | Current Trends in Pickering Emulsions: Particle Morphology and Applications显示文摘In recent years,Pickering emulsions and their applications have attracted a great deal of attention due to their special features,which include easy preparation and enhanced stability.In contrast to classical emulsions,in Pickering emulsions,solid microparticles or nanoparticles that localize at the interface between liquids are used as stabilizers,instead of surfactants,to enhance the droplet lifetime.Furthermore,Pickering emulsions show higher stability,lower toxicity,and stimuli-responsiveness,compared with emulsions that are stabilized by surfactants.Therefore,they can be considered attractive components for various uses,such as photocatalysis and the preparation of new materials.Moreover,the nanoparticle morphology strongly influences Pickering emulsion stability as well as the potential utilization of such emulsions.Here,we review recent findings concerning Pickering emulsions,with a particular focus on how the nanoparticles morphology(i.e.,cube,ellipsoid,nanosheet,sphere,cylinder,rod,peanut)influences the type and stability of such emulsions,and their current applications in different fields such as antibacterial activity,protein recognition,catalysis,photocatalysis,and water purification. | Danae Gonzalez Ortiz Celine Pochat-Bohatier Julien Cambedouzou Mikhael Bechelany Philippe Miele | 2020 | Engineering2020，6，4： | 22 |
| 8 | 综合性卒中中心医疗质量的度量标准:对脑卒中联盟综合性卒中中心推荐意见的详细随访美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘背景卒中是一种主要的残疾和死亡原因。脑卒巾联盟提议,建立初级卒中中心(primary stroke center,PSC)和综合性卒中中心(comprehensive stroke center,csc)以分别为需要基本或高级下预的卒中患者提供适当的医疗服务。从2003年开始,美国医疗卫生机构认证联合委员会和各州已指定了一些PSC,目前正在考虑CSC的指定工作。为了推进该过程,我们提出了一套CSC应追踪监测医疗质量并促进质量改进的标准和相关数据。方法和结果我们分析了现有指南、综述和其他文献,以识别区分CSC与PSC的主要特征;起草了一套标准和相关数据元素,以评价这些卒中医疗方面的关键部分;然后通过反复修改达成共识。我们提出的这套标准和相关数据元素,涵盖了CSC内缺血性脯血管病、非外伤性蛛网膜下腔出血和腩出血患者专、№医疗的主要方面。结论我们提出这套标准,旨在为CSC的标准化数据采集提供一个框架,以促进当地医疗质量改进,并允许对来自不同CSC的数据进行合并分析。这将有助于将来CSC国家执行标准的制定。 | 何晟(译) 蔡可夫(译) 张元媛(译) 胡旻婧(译) 倪耀辉(译) 芮瑛(译) 柯开富(译) Dana Leifer Dawn M. Bravata J.J. (Buddy) Connors Ⅲ Judith A. Hinchey Edward C. Jauch S. Claibome Johnston Richard Latchaw William kikosky Christopher Ogilvy Adrian I. Qureshi Debbie Summers Gene Y. Sung Linda S. Williams Richard Zorowitz | 2011 | 国际脑血管病杂志2011，19，3： | 21 |
| 9 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 10 | Immune checkpoint inhibitor-induced colitis:A comprehensive review显示文摘Immune checkpoint inhibitors(ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand 1.ICIs have revolutionized the treatment of a variety of malignancies. However,many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis(IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease,however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. | Aniruddh Som Rohan Mandaliya Dana Alsaadi Maham Farshidpour Aline Charabaty Nidhi Malhotra Mark C Mattar | 2019 | World Journal of Clinical Cases2019，7，4： | 14 |
| 11 | Impact of on-range choice feeding with black soldier fly larvae(Hermetia illucens)on flock performance,egg quality,and range use of free-range laying hens显示文摘Semi-intensive free-range farm systems are common in Australia, and these systems frequently practise on-range feeding. The objective of this study was to investigate the benefit of on-range choice feeding on flock performance, egg quality, and range use of free-range laying hens using black soldier fly larvae(Hermetia illucens, BSF). A total of 160 mature ISA brown laying hens, previously determined to range daily, were allocated to a control group(control) or a treatment group(BSF) with various replicates depending on the parameter investigated. All hens were fed ad libitum indoors with a wheat-soy based diet formulated according to breed requirements. Black soldier fly hens were offered dried BSF larvae ad libitum on the range. Body weight, feed intake, BSF intake, egg production, feed conversion ratio, internal and external egg quality parameters, and individual range use using radio-frequency identification(RFID)technology was evaluated. Black soldier fly hens consumed on average 15 ± 1.7 g BSF larvae/hen per day.There were no differences between BSF and control hens for any of the performance parameters obtained(P > 0.05). Egg weight, shell weight, and shell thickness of eggs from BSF hens were significantly lower(P = 0.003, P = 0.001, and P = 0.004, respectively) than those of eggs from control hens. Egg yolk colour was significantly paler in eggs from BSF hens(P < 0.001). No significant ranging differences between the BSF and control hens were observed(P > 0.05) except for BSF hens showing longer total maximum time for a single visit to the range(P = 0.011). In conclusion, the average intake of BSF larvae indicated a good level of acceptance. Feed formulation should be adjusted for the intake of the choice fed source. The impact of choice-feeding on range use was minor. | Isabelle Ruhnke Camille Normant Dana L.M.Campbell Zafar Iqbal Caroline Lee Geoff N.Hinch Julie Roberts | 2018 | Animal Nutrition2018，，4： | 12 |
| 12 | RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement显示文摘The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α1.CreER^(TM+).RANKL^(f/f)) and compared results with littermate controls(Col1α1.CreER^(TM-).RANKL^(f/f)). By examination of Col1α1.CreER^(TM+).ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. Thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces. | Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung Dana T. Graves | 2018 | International Journal of Oral Science2018，10，1： | 10 |
| 13 | The Role and Function of Ras-association domain family in Cancer:A Review显示文摘Ras gene mutation has been observed in more than 30%of cancers,and 90%of pancreatic,lung and colon cancers.Ras proteins(K-Ras,H-Ras,N-Ras)act as molecular switches which are activated by binding to GTP.They play a role in the cascade of cell process control(proliferation and cell division).In the inactive state,transforming GTP to GDP leads to the activation of GTpase in Ras gene.However,the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the protein.The activated Ras can promote the cell death or stop cell growth,which are facilitated by Ras-association domain family.Various studies have been conducted to determine the importance of losing RASSF proteins in Rasinduced tumors.This paper examines the role of Ras and RASSF proteins.In general,RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors. | Mohammad Reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid Reza Mirzaei Mohammad Esmaeil Akbari Seyed Rouhollah Miri | 2019 | Genes & Diseases2019，6，4： | 10 |
| 14 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 15 | GADD45β基因表达诱导对不同p53状态的肝癌细胞作用显示文摘目的:体外合成GADD45β基因全序列表达质粒后,研究GADD45β基因表达诱导对呈不同p53状态的肝癌细胞的作用及可能机制。方法:采用RT-PCR法获得GADD45β基因全序列,插入pDrive穿梭克隆载体和pIRES2-EGFP荧光表达载体后大量扩增获得DNA,结合p53全基因表达质粒pp53-EGFP转染HepG2、Hep3B细胞后,以[3H]胸腺嘧啶脱氧核苷掺入法(3H-Tdr)和细胞克隆形成法分析DNA合成变化及细胞生长能力;以双抗体夹心ELISA法测定TGF-β1表达变化。结果:成功合成GADD45β基因全序列和表达质粒,通过流式细胞仪收集转染阳性的荧光表达细胞能显著提高转染效率;转染GADD45β后,具有野生型p53基因的HepG2细胞的细胞克隆形成能力和DNA合成能力明显受到抑制,细胞凋亡明显增加,TGF-β1的表达亦明显受抑。与之相反,缺失p53基因的Hep3B需要同时共转染p53基因后,方出现抑制效应。结论:GADD45β基因能够有效抑制肝癌细胞的生长,其功能需要完整p53基因的辅助和(或)调控。GADD45表达和(或)功能异常,导致p53介导的DNA损伤修复途径异常或阻断,是肝脏细胞恶性转化及形成肿瘤的可能机制。 | 邱伟华 Dana Darwish Peiguo G.Chu Frank Luh 陈皓 邓侠兴 沈柏用 杨卫平 李宏为 Yun Yen | 2005 | 外科理论与实践2005，10，2： | 6 |
| 16 | Modified TiO_(2) based photocatalysts for improved air and health quality显示文摘Photocatalysis with modified titania is a promising approach to improve both air and health quality.Modified titania with novel photocatalytic properties under indoor light irradiation leads to smart coatings,which are benchmark materials suitable for their indoor applications.It is generally accepted that the photocatalytic activity is affected by the light absorption,charge creation/recombination rate and surface reactivity.In this contribution we focus on modified TiO_(2) as catalyst in heterogeneous photocatalytic processes and address the efficiency of TiO_(2)-based building and construction materials on the removal of environmental pollutants indoors and outdoors.We also present data on the presence of eventually formed,toxicologically relevant and harmful by-products as the result of the photo-induced degradation of pollutants in an effort for better evaluation of induced risks for human health from the application of TiO_(2) modified materials.Finally,we present recent results on the disinfection performance of these material and the inactivation of severe pathogens contained in water and indoor air environments. | Vassilios Binas Danae Venieri Dimitrios Kotzias George Kiriakidis | 2017 | Journal of Materiomics2017，3，1： | 6 |
| 17 | STAT3在SAMe抑制HepG2细胞VEGF表达中的作用显示文摘目的研究肝癌细胞(HepG2)和正常胎肝细胞(CL-48)血管内皮生长因子(VEGF)和信号转导与转录激活因子3(STAT3)的表达状态,以及S-腺苷甲硫氨酸(SAM e)对其的干预作用,为HepG2和CL-48的不同调控途径提供功能性依据。方法在对数生长期的CL-48和HepG2细胞中加入不同浓度的SAM e(0、0.5、1.0 mmol/L)作用72 h,分别采用Northern印迹法、实时荧光定量PCR、W estern印迹法以及[3H]胸腺嘧啶脱氧核苷掺入法(3H-Tdr)和细胞克隆形成法,观察VEGF和STAT3表达的变化趋势,分析DNA合成及细胞生长能力的变化。结果SAM e作用前(SAM e 0 mmol/L),HepG2和CL-48均呈现VEGF和STAT3高表达状态。SAM e作用后:HepG2的VEGF和STAT3表达明显降低,并呈现剂量-效应关系,DNA合成和细胞生长能力明显受限;CL-48的STAT3表达虽然受到抑制,但VEGF的高表达状态无明显降低趋势,且DNA合成和细胞生长能力无显著变化。结论虽然HepG2和CL-48均呈现VEGF和STAT3的高表达,但二者具有不同的调控途径;SAM e通过抑制STAT3的组成性活化而降低VEGF的高表达状态,可能是SAM e的肝脏保护机制之一。 | 邱伟华 Bingsen Zhou Dana Darwish Peiguo G.Chu Frank Luh 陈皓 杨卫平 李宏为 Yun Yen | 2006 | 上海交通大学学报(医学版)2006，26，6： | 6 |
| 18 | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis显示文摘BACKGROUND The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity(SO)and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its potential negative effects on health outcomes.AIM To conduct a systematic review to determine the prevalence of sarcopenia among adults with overweight and obesity and to investigate whether SO was associated with a higher risk of type 2 diabetes(T2 D).METHODS This study was conducted in adherence with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Literature searches, study selection, methodology development and quality appraisal were performed independently by two authors and the data were collated by means of metaanalysis and narrative synthesis.RESULTS Of the 606 articles retrieved, 11 studies that comprised a total of 60118 adults with overweight and obesity of both genders met the inclusion criteria and were reviewed, revealing two main findings. First, the overall prevalence of sarcopenia is 43% in females and 42% in males who are with overweight and obesity.Secondly, the presence of SO increases the risk of T2D by 38% with respect to those without SO(OR = 1.38, 95%CI: 1.27-1.50).CONCLUSION A high prevalence of sarcopenia has been found among adults with overweight and obesity regardless of their gender and this condition seems to be associatedwith a higher risk of T2D. Clinician should be aware of this scenario in their clinical practice for the better management of both obesity and T2D. | Dima Khadra Leila Itani Hana Tannir Dima Kreidieh Dana El Masri Marwan El Ghoch | 2019 | World Journal of Diabetes2019，10，5： | 6 |
| 19 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 20 | Nanomaterials for treating cardiovascular diseases:A review显示文摘Nanomaterials such as nanostructured surfaces,nanoparticles,and nanocomposites represent new viable sources for future therapeutics for cardiovascular diseases.The special properties of nanomaterials such as their intrinsic physiochemical properties,surface energy and surface topographies could actively enhance desirable cellular responses within the cardiovascular system,projecting a growing potential for clinical translation.Recent progress on nanomaterials opened up new opportunities for treating cardiovascular diseases.Successful translation of nanomaterials into cardiovascular applications requires a comprehensive understanding of both nanomaterials and biomedicine,and,thus,it is critical to stress current advancements on both sides.In this review,the authors introduced crucial fabrication techniques for promising nanomaterials for cardiovascular applications.This review highlighted the key elements to consider for their fabrication,properties and applications.The important concerns relevant to cardiovascular nanomaterials,such as cellular responses to nanomaterials and the toxicity of nanomaterials,are also discussed.This review provided an overview of necessary knowledge and key concerns on nanomaterials specific for treating cardiovascular diseases,from the perspectives of both material science and biomedicine. | Wensen Jiang Dana Rutherford Tiffany Vuong Huinan Liu | 2017 | Bioactive Materials2017，2，4： | 6 |
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