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| 1 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Effects of orthography on speech production in a form-preparation paradigm 显示文摘 | Damian M F Bowers J S | 2003 | Journal of Memory and Language2003，49，： | 1 |
| 3 | Multiscale Description of the Inhomogeneity of Multiphase Materials 显示文摘 | JERZY C DAMIAN S JANUSZ S | 2009 | Materials Characterization2009，60，： | 1 |
| 4 | Locus of Semantic Interference in Picture - word Interference Tasks显示文摘 | Damian M F Bowers J S | 2003 | Psyehonomic Bul- letin & Review2003，10，1： | 1 |
| 5 | Purification and characterization of a metacestode cysteine proteinase from Taenia solium involved in the breakdown of human IgG显示文摘 | Baig S Damian R T Molinari J L | 2005 | Parasitology2005，131，3： | 1 |
| 6 | Genomic imprinting and seed development:endosperm formation with and without sex显示文摘 | UELI G CHARLES S DAMIAN R P | 2001 | Current Opinion in Plant Biology2001，4，： | 1 |
| 7 | Development sediment quality criteria显示文摘 | Damian S | 1988 | Environmental Sciences&Technology1988，22，11： | 1 |
| 8 | Purification and character- ization of a metacestode cysteine proteinase from Taenia solium in- volved in the breakdown of human IgG 显示文摘 | Baig S Damian RT Molinari JL | 2005 | Parasitology2005，131，3： | 1 |
| 9 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 10 | Development sediment quality criteria显示文摘 | Damian S | 1988 | Envi-ronmental Sciences Technology1988，22，11： | 1 |
| 11 | ITS-RFLP and se- quence analysis of endophytes from Acianthus, Caladenia and Pterostylis (()rchidaceae) in southeastern Queensland 显示文摘 | Jeremy J B Damian S B John W G C | 2005 | Mycol Res2005，109，4： | 1 |
| 12 | Precontoured Parallel Plate Fixation of AO/OTA Type C Distal Humerus Fractures显示文摘 | George S Athwal Samuel C Hoxie Damian M Rispoli Scott P Steinmann | 2009 | Journal of Orthopaedic Trauma2009，，8： | 1 |
| 13 | Development sediment quality criteria 显示文摘 | DAMIAN S | 1988 | Environmental Science & Technology1988，22，11： | 1 |
| 14 | Managingand Sharing Servents'Reputations in P2P Systems显示文摘 | Damian E di Vimercati S D C Paraboschi S | 2003 | IEEETransactions on Data and Knowledge Engineering2003，15，4： | 1 |
| 15 | Solar photoconver- sion using graphene/TiO2 composites: Nanographene shell on TiOe core versus TiOe nanoparticles on graphene sheet显示文摘 | Kim H I Moon G H Damian M S | 2012 | J Phys Chem C2012，116，1： | 1 |
| 16 | Direct Ex- traction of the A1GaAs/GaAs Hetero-junction Bipolar Tran- sistor Small-Signal Equivalent Circuit显示文摘 | Damian Costa William U Liu James S Harris | 1991 | IEEE TRANSAC- TION ON ELECTRON DEVICE1991，38，9： | 1 |
| 17 | Protection from murine cysticercosis by immunization with a parasite cysteine protease 显示文摘 | Baig S Damian RT Morales-Montor J | 2006 | Microbes Infect2006，8，1213： | 1 |
| 18 | Ultraviolet A Radiation : ItsRole in Immunosuppression and Carcinogenesis 显示文摘 | Halliday G M Byme S N Damian D L | 2011 | Semin CutanMed Surg2011，30，4： | 1 |
| 19 | Multiscale description of theinhomo-geneity of multiphase materials显示文摘 | Jerzy C Damian S Janusz S | 2009 | Materials Char-acterization2009，，60： | 1 |
| 20 | Preconcentration of Zn(Ⅱ) in water samples using a new hybrid SBA-15-based material显示文摘 | DAMIAN P Q ALFREDO S ISABEL D H | 2009 | J Hazard Mater2009，166，23： | 1 |
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