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| 1 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 2 | 选择性雄激素受体调节剂治疗迟发性男性性腺功能低下症显示文摘几种睾酮制剂用于治疗老年男性性腺功能减退。这些疗法在其便利性、灵活性、区域供应和费用等方面有区别,但有共同的药代动力学基础,同时缺乏长期安全性数据。简洁和成本较低的基于药代动力学的注册临床试验使得开发改善性的治疗迟发性性腺功能减退的新疗法的商业动机减少了。在前列腺、头发、皮肤受雄激素缺乏影响的患者中,选择性雄激素受体调节剂已被证明可以提供合成代谢的好处。(目前,选择性雄激素受体调节剂的临床进展集中在有限定身体功能的临床终点的急性肌肉萎缩和低体重)。在具有有益的药理、理想的药代动力学的选择性雄激素受体调节剂应用于治疗迟发性男性性腺功能低下症前,其在男性性腺功能低下治疗中关于临床缺陷的更清晰的监管是必须的。 | Christopher C Coss Amanda Jones Michael L Hancock Mitchell S Steiner James T Dalton | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 3 | Antidepressant medications and risk for cancer显示文摘 | Johansen C Mellemkjaer L | 2000 | Epidemiology2000，11，2： | 1 |
| 4 | Efficiency and weight trade- off analysis of regenerative fuel cells as energy storage for aerospace applications显示文摘 | BARBIR F MOLTER T DALTON L | 2005 | International Journal of Hydrogen Energy2005，30，4： | 1 |
| 5 | Homocysteine signal cascad: production of phosphslipids, activation of protein kinase C , and the induction of c-los and c-myb in smooth muscle cells显示文摘 | DALTON M L GADSON P F WRENN R W | 1997 | FASEB J1997，11，： | 1 |
| 6 | Fluorescence intensity and squeezing in a driving three-level atom:ladder case显示文摘 | Ficek Z Dalton B J Knight P L | 1995 | Phys Rev1995，51，5： | 1 |
| 7 | Properties of Portland cement made from contaminated sediments 显示文摘 | Jennifer L Dalton Kevin H Gardner | 2004 | Conservation and Recycling2004，41，3： | 1 |
| 8 | Transthoracic echocardiography in models of cardiac disease in the mouse显示文摘 | Tanaka N Dalton N Mao L | 1996 | Circulation1996，94，： | 1 |
| 9 | Use of Bar-tonella antigens for serologic diagnosis of cat-scratchdisease at a national referral center 显示文摘 | Dalton M J Robinson L E Cooper J | 1995 | Arch InternMed1995，155，15： | 1 |
| 10 | Recent advances in non-linear of spectroscopy and nonlinear optical materials显示文摘 | Dalton L R Sapochak L S | 1993 | J Phys Chem1993，97，： | 1 |
| 11 | Intrauterine adhesions after manual vacuum aspiration for early pregnancy failure 显示文摘 | Dalton V K Saunders N A Harris L H | 2006 | Feail Steril2006，85，6： | 1 |
| 12 | Astigmatism compensation in the Czerny- Turner spectrometer显示文摘 | DALTON M L | 1966 | Applied Optics1966，5，7： | 1 |
| 13 | Intervertebral disc biacuplasty for the treatment of lumbar discogenic pain: results of a six-month follow-up 显示文摘 | Kapural L Dalton J Mascha E | 2008 | Pain medicine2008，1，9： | 1 |
| 14 | Recent advances in non-linear of spectroscopy and nonlinear optical materials显示文摘 | Sapochak L S | 1993 | J Phys Chem1993，97，12： | 1 |
| 15 | Mind and cancer:Does psychosocial intervention improve survival and psychological well-being?显示文摘 | Ross L Boesen EH Dalton SO | 2002 | Eur J Cancer2002，38，11： | 1 |
| 16 | Composition of the top management team and firm international diversification 显示文摘 | Tihanyi L Ellstrand A E Daily C M Dalton D R | 2000 | Journal of Management2000，26，6： | 1 |
| 17 | Management of general surgical problems in the pregnant patient显示文摘 | David M Melnick Wendy L Wahl Vanessa K Dalton | 2004 | The American Journal of Surgery2004，，2： | 1 |
| 18 | Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A (H1N1) pdm09 influenza in Australia显示文摘 | Hurt A C Hardie K Wilson N J Deng Y M Oshourn M Leang S K Lee R T Iannello P Gehrig N Shaw R Wark P Caldwell N Givney R C Xue L Maurer- Stroh S Dwyer D E Wang B Smith D W Levy A Booy R Dixit R Merritt T Kelso A Dalton C Durrheim D Barr I G | 2012 | J Infect Dis2012，206，2： | 1 |
| 19 | Composition of the Top Management Team and Firm International Diversification显示文摘 | TIHANY1 L ELLSTRAND A E DAILY C M DALTON D R | 2000 | Jour- nal of Management2000，26，6： | 1 |
| 20 | Emerging knowledge about planning practice显示文摘 | DALTON L | | 0，，01： | 1 |
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