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| 1 | Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference显示文摘AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan■ (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study.All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixtyeight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%); P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ± 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ± 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ≤ 13.0 kPa); and 2.55 ± 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ≥ 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis. | Gerald Kircheis Abdurrahman Sagir Christoph Vogt Stephan vom Dahl Ralf Kubitz Dieter Hussinger | 2012 | World Journal of Gastroenterology2012，18，10： | 30 |
| 2 | 高地应力岩体特殊照明峒室围岩支护设计显示文摘为特殊照明和交通安全在世界最长的双峒公路隧道——秦岭终南山隧道内设计了6个峒室,该隧道穿越中国陕西省秦岭山脉,最大埋深达1 800 m。在峒址附近的2个位置采用应力解除法量测岩石地应力,该处的岩石覆盖厚度分别为1 600和400 m,量测结果显示极高的地应力。为满足照明和行车安全的要求,每个峒室设计成纺锤型,长度为200 m,最大宽度为22 m。受到已建成隧道的限制,两峒室间最小岩柱厚度只有8 m。峒室的主要特征为:(1)高地应力;(2)岩石条件较好;(3)与峒室尺寸相比岩柱厚度很小,这些特征对围岩支护提出极大的挑战。围岩支护是依据岩体分类Q系统采用经验法设计,然后采用数值分析校核。临时支护和永久支护系统均采用喷射混凝土和锚杆。为保证施工和运行期的峒室稳定提出一整套实施程序,包括开挖、喷射混凝土、安装锚杆和监控措施。对于极高地应力区域的峒室采用柔性支护,允许岩体在永久支护安装前发生部分变形,从而保证峒室稳定及支护元件安全可靠地发挥效用。分别采用FLAC3D和Phase 2程序进行三维和二维数值分析,三维计算主要用于研究峒室的整体稳定及沿隧道轴向的三维效应;二维计算用于详细研究施工顺序和各支护单元的功效。数值分析显示喷射混凝土和锚杆在各施工阶段都能安全运作,从而验证了围岩支护设计。 | 吕明 GRφV E DAHLE H 乔怀玉 文邦后 陈忠明 赵秋林 | 2008 | 岩石力学与工程学报2008，27，1： | 4 |
| 3 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 4 | Grain refinement efficiency and mechanism of aluminum carbide in Mg-A1 alloys 显示文摘 | Lu L Dahle A K Stjohn D H | 2005 | Scripta Materialia2005，53，5： | 1 |
| 5 | The role of solute in grain refinement of magnesium显示文摘 | Lee Y C Dahle A K StJohn D H | 2000 | Metallurgical and Materials Transactions A2000，31，11： | 1 |
| 6 | The value of 'multimodeal' or 'balanced analgesia' in postoperative pain treatment显示文摘 | Kehlet H Dahl JB | 1993 | Anesth Analg1993，77，5： | 1 |
| 7 | Development of the as-cast microstructure in magnesium?aluminium alloys 显示文摘 | DAHLE K A LEE Z C NAVE M D SCHAFFER P L JOHNSON D H | 2001 | Light Metals2001，，1： | 1 |
| 8 | A qualitative and quantitive systematic review of preemptive analgesia for postoperative pain relief:the role of timing of analgesia显示文摘 | Moiniche S Kehlet H Dahl JB | 2002 | Anesthesiology2002，96，： | 1 |
| 9 | The Troms So-cial Intelligence Scale,a self-report measure of social in-telligence显示文摘 | Silvera D H Martinussen M Dahl T I | 2001 | Scand J Psychol2001，42，4： | 1 |
| 10 | Developments and Chal- lenges in the Utilization of Magnesium Alloys 显示文摘 | Dahle A K John D H Dunlop G L | 2000 | Mater Forum2000，，24： | 1 |
| 11 | Cellular versus acellular ma- trix devices in treatment of diabetic foot ulcers : study protocol for a comparative efficacy randomized controlled trial 显示文摘 | Lev-Tov H Li CS Dahle S | 2013 | Trials2013，14，： | 1 |
| 12 | Liver cell hydration显示文摘 | D. H?ussinger F. Schliess U. Warskulat S. vom Dahl | 1997 | Cell Biology and Toxicology (-)1997，，4： | 1 |
| 13 | A qualitative and quantita- tive systematic review of preemptive analgesia for postopera- tive pain relief:the role of timing of analgesia显示文摘 | Mφiniche S Kehlet H Dahl JB | 2002 | Anesthe- siology2002，96，3： | 1 |
| 14 | The role of solute in grain refinement of magnesium 显示文摘 | LEE Y C DAHLE A K STJOHN D H | 2000 | Metallurgical and MaterialsTransactions A2000，31，： | 1 |
| 15 | Anaesthesia surgery and challenges in post - operative recovery 显示文摘 | Kehlet H Dahl J B | 2003 | Lancet2003，362，9399： | 1 |
| 16 | The corrected operator splitting approach applied to a nonlinear advection - diffusion problem显示文摘 | Kadsen K H Brusdai K Dahle H K | 1998 | Comput Methods Appl Mech Eng1998，167，： | 1 |
| 17 | Interesting interest points 显示文摘 | Aanzes S H Dahl A Pedersen K S | 2012 | International Journal of Computer Vision2012，97，1： | 1 |
| 18 | A qualitative and quantitative sys- tematic review of preemp rive analgesia for postoperative pain relief 显示文摘 | Moiniche S Kehlet H Dahl JB | 2002 | Anesthesiology2002，96，： | 1 |
| 19 | Agualitative systematic review of preenptive analgesia for postoperative pain relief:the role of analgesia 显示文摘 | Moiniche S Kehlet H Dahl JB | 2002 | Anesthesiology2002，96，4： | 1 |
| 20 | Comparison of the characteristics of bottom ash and fly ash from a medium size (32MW)municipal district heating plant incinerating for est residues and peat in a fluidized-bed boiler显示文摘 | Dahl O Nurmesniemi H Poykio R | 2009 | Fuel Processing Technolo~y2009，90，78： | 1 |
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