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| 1 | CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products: An updated review显示文摘The disinfection of drinking water is an important public health service that generates high quality, safe and palatable tap water. The disinfection of drinking water to reduce waterborne disease was an outstanding public health achievement of the 20 th century.An unintended consequence is the reaction of disinfectants with natural organic matter,anthropogenic contaminants and bromide/iodide to form disinfection by-products(DBPs).A large number of DBPs are cytotoxic, neurotoxic, mutagenic, genotoxic, carcinogenic and teratogenic. Epidemiological studies demonstrated low but significant associations between disinfected drinking water and adverse health effects. The distribution of DBPs in disinfected waters has been well defined by advances in high precision analytical chemistry. Progress in the analytical biology and toxicology of DBPs has been forthcoming.The objective of this review was to provide a detailed presentation of the methodology for the quantitative, comparative analyses on the induction of cytotoxicity and genotoxicity of103 DBPs using an identical analytical biological platform and endpoints. A single Chinese hamster ovary cell line was employed in the assays. The data presented are derived from papers published in the literature as well as additional new data and represent the largest direct quantitative comparison on the toxic potency of both regulated and emerging DBPs.These data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better. | Elizabeth D.Wagner Michael J.Plewa | 2017 | Journal of Environmental Sciences2017，29，8： | 70 |
| 2 | TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water显示文摘The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products(DBPs). Many of the identified DBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the environment.Only a few DBPs are regulated by several national and international agencies and it is not clear if these regulated DBPs are the forcing agents that drive the observed toxicity and their associated health effects. In this study, we combine analytical chemical and biological data to resolve the forcing agents associated with mammalian cell cytotoxicity of drinking water samples from three cities. These data suggest that the trihalomethanes(THMs) and haloacetic acids may be a small component of the overall cytotoxicity of the organic material isolated from disinfected drinking water. Chemical classes of nitrogen-containing DBPs, such as the haloacetonitriles and haloacetamides, appear to be the major forcing agents of toxicity in these samples. These findings may have important implications for the design of epidemiological studies that primarily rely on the levels of THMs to define DBP exposure among populations. The TIC-Tox approach constitutes a beginning step in the process of identifying the forcing agents of toxicity in disinfected water. | Michael J.Plewa Elizabeth D.Wagner Susan D.Richardson | 2017 | Journal of Environmental Sciences2017，29，8： | 15 |
| 3 | The impact of iodinated X-ray contrast agents on formation and toxicity of disinfection by-products in drinking water显示文摘The presence of iodinated X-ray contrast media(ICM) in source waters is of high concern to public health because of their potential to generate highly toxic disinfection by-products(DBPs). The objective of this study was to determine the impact of ICM in source waters and the type of disinfectant on the overall toxicity of DBP mixtures and to determine which ICM and reaction conditions give rise to toxic by-products. Source waters collected from Akron,OH were treated with five different ICMs, including iopamidol, iopromide, iohexol,diatrizoate and iomeprol, with or without chlorine or chloramine disinfection. The reaction product mixtures were concentrated with XAD resins and the mammalian cell cytotoxicity and genotoxicity of the reaction mixture concentrates was measured. Water containing iopamidol generated an enhanced level of mammalian cell cytotoxicity and genotoxicity after disinfection. While chlorine disinfection with iopamidol resulted in the highest cytotoxicity overall, the relative iopamidol-mediated increase in toxicity was greater when chloramine was used as the disinfectant compared with chlorine. Four other ICMs(iopromide, iohexol, diatrizoate, and iomeprol) expressed some cytotoxicity over the control without any disinfection, and induced higher cytotoxicity when chlorinated. Only iohexol enhanced genotoxicity compared to the chlorinated source water. | Clara H.Jeong Edward J.Machek Morteza Shakeri Stephen E.Duirk Thomas A.Ternes Susan D.Richardson Elizabeth D.Wagner Michael J.Plewa | 2017 | Journal of Environmental Sciences2017，29，8： | 11 |
| 4 | Chloramination of wastewater effluent: Toxicity and formation of disinfection byproducts显示文摘The reclamation and disinfection of waters impacted by human activities(e.g., wastewater effluent discharges) are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts(N-DBPs). Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-DBPs. Individual toxicity assays have been performed on many DBPs, but few studies have been conducted with complex mixtures such as wastewater effluents. In this work, we compared the cytotoxicity and genotoxicity of wastewater effluent organic matter(Ef OM) before and after chloramination. The toxicity of chloraminated Ef OM was significantly higher than the toxicity of raw Ef OM, and the more hydrophobic fraction(HPO)isolated on XAD-8 resin was more toxic than the fraction isolated on XAD-4 resin.More DBPs were also isolated on the XAD-8 resin. N-DBPs(i.e., haloacetonitriles or haloacetamides) were responsible for the majority of the cytotoxicity estimated from DBP concentrations measured in the XAD-8 and XAD-4 fractions(99.4% and 78.5%, respectively).Measured DBPs accounted for minor proportions of total brominated and chlorinated products, which means that many unknown halogenated compounds were formed and can be responsible for a significant part of the toxicity. Other non-halogenated byproducts(e.g.,nitrosamines) may contribute to the toxicity of chloraminated effluents as well. | Julien Le Roux Michael J.Plewa Elizabeth D.Wagner Maolida Nihemaiti Azra Dad Jean-Philippe Croué | 2017 | Journal of Environmental Sciences2017，29，8： | 8 |
| 5 | Ultrasonic fatigue tests at high temperature on an austenitic steel显示文摘The objective of this paper is to study the gigacycle fatigue behavior of an austenitic steel at temperatures of 6001C and 700℃under fully reverse loading(R=-1).Numerical simulation by finite element method(FEM)was used to design the specimens and to analyze the effects of the variation in the dynamic Young modulus with temperature from measurements of the ultrasonic resonance frequency.Finally,new stress-life curves for this material are presented for a lifetime range from 10^(5)to 10^(9)cycles at room temperature,600℃and 700℃. | D.Wagner F.J.Cavalieri C.Bathias N.Ranc | 2012 | Propulsion and Power Research2012，1，1： | 6 |
| 6 | 查看详情显示文摘 | Z.Y.Huang D.Wagner C.Bathias | | 0，，： | 1 |
| 7 | 查看详情显示文摘 | Z.Y.Huang D.Wagner C.Bathias | | 0，，： | 1 |
| 8 | Monohalogenated acetamide-induced cellular stress and genotoxicity are related to electrophilic softness and thiol/thiolate reactivity显示文摘Haloacetamides(HAMs) are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an S_N2 reaction mechanism.Toxicity of the monohalogenated HAMs(iodoacetamide, IAM; bromoacetamide, BAM;or chloroacetamide, CAM) varied depending on the halogen substituent. The aim of this research was to investigate how the halogen atom affects the reactivity and toxicological properties of HAMs, measured as induction of oxidative/electrophilic stress response and genotoxicity. Additionally, we wanted to determine how well in silico estimates of electrophilic softness matched thiol/thiolate reactivity and in vitro toxicological endpoints.Each of the HAMs significantly induced nuclear Rad51 accumulation and ARE signaling activity compared to a negative control. The rank order of effect was IAM > BAM > CAM for Rad51, and BAM ≈ IAM > CAM for ARE. In general, electrophilic softness and in chemico thiol/thiolate reactivity provided a qualitative indicator of toxicity, as the softer electrophiles IAM and BAM were more thiol/thiolate reactive and were more toxic than CAM. | Justin A.Pals Elizabeth D.Wagner Michael J.Plewa Menghang Xia Matias S.Attene-Ramos | 2017 | Journal of Environmental Sciences2017，29，8： | 1 |
| 9 | Explorations into the visualization of policy networks显示文摘 | Brandes U P.Kenis J.P aab V.Schneider D.Wagner | | 0，，01： | 1 |
| 10 | Fatigue and Fract显示文摘 | D.Wagner N.Ranc C.Bathias | | 0，，： | 1 |
| 11 | Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection显示文摘 | YanXiao XiugongGao GallyaGannot Michael REmmert‐Buck SudhirSrivastava Paul D.Wagner Michael D.Amos Peter E.Barker | 2008 | Int. J. Cancer2008，，10： | 1 |
| 12 | Neutrophil extracellular traps promote deep vein thrombosis in mice显示文摘 | A.BRILL T. A.FUCHS A. S.SAVCHENKO G. M.THOMAS K.MARTINOD S. F.DE MEYER A. A.BHANDARI D. D.WAGNER | 2012 | Journal of Thrombosis and Haemostasis2012，，： | 1 |
| 13 | B‐type Natriuretic Peptide and Amino‐terminal Pro‐B‐type Natriuretic Peptide in Pediatric Patients with Pulmonary Arterial Hypertension显示文摘 | ShinichiTakatsuki Brandie D.Wagner David DunbarIvy | 2012 | Congenital Heart Disease2012，，3： | 1 |
| 14 | Astigmatic correction with implantation of a light adjustable vs monofocal lens: a single site analysis of a randomized controlled trial显示文摘AIM: To evaluate the light adjustable lens (LAL) vs a standard monofocal lens in achieving target astigmatic refraction and improving postoperative uncorrected distance visual acuity (UDVA).METHODS: This randomized controlled clinical trial included 40 patients with pre-existing astigmatism and visually significant cataract. Twenty-eight patients received the LAL and 12 control patients received a monofocal intraocular lens (IOL) after cataract extraction at a single institution. The patients with the LAL underwent adjustment by ultraviolet (UV) light postoperatively plus subsequent lock-in procedures and all patients returned to clinic for follow up of study parameters at 6, 9, and 12mo. Manifest refraction, distance visual acuity, and adverse events were recorded at each visit. RESULTS: The mean cylinder before adjustment in eyes with the LAL was -0.89±0.58 D (-2.00 to 0.00 D) and -0.34±0.34 D (-1.25 to 0.00 D) after lock-in (P=1.68×10^-8). The mean cylinder in patients with the monofocal lens was -1.00±0.32 D (-1.50 to -0.50 D) at 17-21d postoperatively, which was statistically different from the LAL cylinder post lock-in (P=1.43×10^-6). UDVA in the LAL group was 20/20 or better in 79% of patients post lock-in with good stability over 12mo compared with 33% of the control patients with UDVA of 20/20 or better.CONCLUSION: These results demonstrate that the LAL is more effective in achieving target refractions and improving postoperative UDVA in patients with pre-existing corneal astigmatism than a standard monofocal lens. | Majid Moshirfar William D.Wagner Steven H.Linn David F.Skanchy Tanner W.Brown Aaron T.Gomez Jackson L.Goldberg Yasmyne C.Ronquillo Phillip C.Hoopes Jr. | 2019 | International Journal of Ophthalmology(English edition)2019，12，7： | 1 |
| 15 | Syndecan-4 functionalization of tissue regeneration scaffolds improves interaction with endothelial progenitor cells显示文摘Key to most implanted cell free scaffolds for tissue regeneration is the ability to sequester and retain undifferentiated mesenchymal stem cells at the repair site.In this report,syndecan-4,a heparan sulfate containing proteoglycan,was investigated as a unique molecule for use in scaffold functionalization.An electrospun hybrid scaffold comprised of poly(glycerol)sebacate(PGS),silk fibroin and type I collagen(PFC)was used as a model scaffold to develop a procedure and test the hypothesis that functionalization would result in increased scaffold binding of endothelial progenitor cells(EPCs).For these studies both Syndecan-4 and stromal derived factor-1a(SDF-1a)were used in functionalization PFC.Syndecan-4 functionalized PFC bound 4.8 fold more SDF-1a compared to nonfunctionalized PFC.Binding was specific as determined by heparin displacement studies.After culture for 7 days,significantly,more EPCs were detected on PFC scaffolds having both syndecan-4 and SDF-1a compared to scaffolds of PFC with only syndecan-4,or PFC adsorbed with SDF-1a,or PFC alone.Taken together,this study demonstrates that EPCs can be bound to and significantly expanded on PFC material through syndecan-4 mediated growth factor binding.Syndecan-4 with a multiplicity of binding sites has the potential to functionalize and expand stem cells on a variety of scaffold materials for use in tissue regeneration. | Harleigh Warner Yidi Wu William D.Wagner | 2021 | Regenerative Biomaterials2021，8，6： | 1 |
| 16 | Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by‐products显示文摘 | Michael J.Plewa YahyaKargalioglu DanielleVankerk Roger A.Minear Elizabeth D.Wagner | 2002 | Mutagen2002，，2： | 1 |
| 17 | DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells显示文摘 | Matias S.Attene‐Ramos Gerardo M.Nava Mark G.Muellner Elizabeth D.Wagner Michael J.Plewa H. RexGaskins | 2010 | Environ Mol Mutagen2010，，4： | 1 |
| 18 | 德国农业低地流域土地利用格局的空间解释变量的定量识别分析(英文)显示文摘Land use patterns arise from interactive processes between the physical environment and anthropogenic activities.While land use patterns and the associated explanatory variables have often been analyzed on the large scale,this study aims to determine the most important variables for explaining land use patterns in the 50 km^2 catchment of the Kielstau,Germany,which is dominated by agricultural land use.A set of spatially distributed variables including topography,soil properties,socioeconomic variables,and landscape indices are exploited to set up logistic regression models for the land use map of 2017 with detailed agricultural classes.Spatial validation indicates a reasonable performance as the relative operating characteristic (ROC) ranges between 0.73 and 0.97 for all land use classes except for corn (ROC = 0.68).The robustness of the models in time is confirmed by the temporal validation for which the ROC values are on the same level (maximum deviation 0.1).Non-agricultural land use is generally better explained than agricultural land use.The most important variables are the share of drained area,distance to protected areas,population density,and patch fractal dimension.These variables can either be linked to agriculture or the river course of the Kielstau. | 雷超桂 Paul D.WAGNER Nicola FOHRER | 2019 | Journal of Geographical Sciences2019，29，11： | 1 |
| 19 | The role of BCL6 in lymphomas and routes to therapy显示文摘 | Simon D.Wagner MatthewAhearne Paul KoFerrigno | 2010 | British Journal of Haematology2010，，1： | 1 |
| 20 | 屈服点的不稳定性对超高周疲劳的影响研究显示文摘核电站的蒸汽发生器管道采用碳锰钢制成,设计寿命40年,长期受循环温度载荷和高频振动载荷作用后,在管道连接处出现裂纹。实际工作中,循环温度载荷作用后的材料产生循环塑性变形,屈服点这一重要力学性能发生变化。材料在单向拉伸载荷作用下超过Lüders带后,出现硬化效应,屈服强度提高。研究屈服应力点的变化对材料的超高周疲劳性能的影响。试验采用压电陶瓷超声疲劳试验机,考察并比较单向拉伸、低周疲劳载荷作用后,材料超高周疲劳性能的变化。实验结果表明:单向拉伸(5%)提高了材料的屈服点,同时也提高了超高周疲劳强度;而低周疲劳载荷作用后,随着屈服应力点的降低,超高周疲劳性能下降。 | 黄志勇 陈伟 D.Wagner C.Bathias | 2012 | 机械科学与技术2012，31，2： | 0 |
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