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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The cost of hospitalization in Crohn’s disease显示文摘 | Russell D Cohen Leanne R Larson Joel M Roth Russell V Becker Lisa L Mummert | 2000 | The American Journal of Gastroenterology2000，，2： | 2 |
| 3 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996，275，20： | 1 |
| 4 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 5 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 6 | The effect of removing the true dental follicle on premolar eruption in the dog 显示文摘 | LARSON E K CAHILL D R GORSKI J P | 1994 | Arch Oral Biol1994，39，4： | 1 |
| 7 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 8 | Water - soluble quantum dots for muitiphoton fluorescence imaging in vivo 显示文摘 | Larson D R Zipfel W R Williams R M | 2003 | Science2003，300，5624： | 1 |
| 9 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 10 | An Examination of the Spectra of the 'Kick-out' Pulses for a Proposed Sampling Oscilloscope Calibration Method显示文摘 | Paulter N G Larson D R | 2001 | IEEE Trans on IM2001，50，5： | 1 |
| 11 | Amelioration of ischemia- reperfusion injury with cyclic peptide blockade of ICAM-1 显示文摘 | Merchant S Gurule D Larson R | 2003 | Am J Physiol Heart Circ Physiol2003，284，4： | 1 |
| 12 | Local Derivations and Automorphisms of B(X)显示文摘 | Larson D R Sourour A R | | 0，，： | 1 |
| 13 | Operator-valued measures, dilations, and the theory of frames 显示文摘 | HAN D LARSON D R LIU B | 2014 | Mem Amer Math Soc2014，229，1075： | 1 |
| 14 | Etiology and treatment of chemotherapeutic agent extravasation injuries: A review显示文摘 | Rudolph R Larson D | 1987 | J Clin Oncol1987，32，5： | 1 |
| 15 | Pulse Parameter Uncertainty Analysis显示文摘 | Paulter N G Larson D R | 2002 | Metrologia2002，39，： | 1 |
| 16 | Responding to emergencies: Lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 17 | Sources of Uncertainty in the Nose-to-Nose Sampler Calibration Method显示文摘 | Paulter N G Larson D R | 2003 | IEEE Trans on IM2003，52，5： | 1 |
| 18 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
| 19 | Is gratitude a moral affect 显示文摘 | McCullough M E Kilpatrick S D Emmons R A larson D B | 2001 | Psychological Bulletin2001，127，24： | 1 |
| 20 | Nest Subalgebras of Von Neumann Algebras 显示文摘 | F Gilfeather D R Larson | 1982 | Adv Math1982，46，： | 1 |
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