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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Influence of Coal Nature and Structure on Ash Size Formation Characteristic and Related Pollutant Emissions During CFB Combustion显示文摘The size distribution of coal particles in a Circulating Fluidized Bed (CFB) boiler plays a crucial role in the complicated combustion, heat exchange and pollutant emissions in such a plat. Therefore, it is fundamental to study the different factors having influence on the size distribution of coal particles. Above all, the coal itself and in particular, the coal combination phenomenon is a very influent factor. In the frame of this work, the coal nature (elementary composition) and coal internal structure (mineral components) are studied in detail. At this intermediary stage, experiments on three typical Chinese coals on a l.5 MWt CFBC pilot plant have been made. Some primary fragmentation tests have also been made in a small lab scale fluidized bed reactor. The results from the hot pilot test show i) the variation of coal ash distributions and other CFB performance data due to the cyclone and the coal characteristics and ii) the variation of desulfurization efficiency with limestone. Whereas the bench scale primary fragmentation test, likely linked to the caking propriety of a coal, does not seem to change considerably the char size distribution. | Min QIAN Arnaud BOELLE Philippe JAUD ( Electricite de France Division R&D, 6 quai Watier B.P.49 78401 Chatou, France ) Yongjie NA Qinggang LU Shaolin BAO ding CUI Weihong JIAO Huanming ZHAO (Institute of Engineering Thermophysics, Chinese Academ | 2000 | Journal of Thermal Science2000，9，3： | 2 |
| 3 | Theory for constructing generalized synchronization and synchronization and applications显示文摘 | ZHANG X D MIN L Q | 2000 | Journal of University of Science and Technology Beijing2000，，7： | 1 |
| 4 | Paleomagnetotectonics of East Asia in the Proto-Tethys Ocean显示文摘 | Lee Y S Nishimura S Min K D | 1997 | Tectonophysics1997，270，： | 1 |
| 5 | Molecular, cellular,and functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2 显示文摘 | Lillehoj H S Min W Choi K D | 2001 | Vet Immunol Immunopathol2001，82，34： | 1 |
| 6 | Burial of organic carbon in Holocene sediments of the Zhujiang (Pearl River) and Changjiang (Yangtze River) estuaries 显示文摘 | Yang Shouye Tang Min Yim W W S Zong Yongqiang Huang Guangqing Switzer A D Saito Y | 2011 | Mar Chem2011，123，14： | 1 |
| 7 | Implantable silk composite microneedles for programmable vaccine release ki- netics and enhanced immunogenicity in transcutaneous immu- nization显示文摘 | DEMUTH P C MIN Y IRVINE D J | 2014 | AdvHealthcMater2014，3，1： | 1 |
| 8 | Isolation of limonoids and alkaloids from Phellodendron amurense and their multidrug resistance(MDR) reversal activity显示文摘 | Min Y D Kwon H C Yang M C | 2007 | Arch Pharm Res2007，30，1： | 1 |
| 9 | A novel approach for lignin modification and degradation 显示文摘 | TIAN Min WEN Jiali DUNCAN M D | 2010 | Electrochemistry Communications2010，12，： | 1 |
| 10 | Genetic algorithm solution of ground water management models 显示文摘 | McKinney D C Min D L | 1994 | Water Resources Research1994，30，6： | 1 |
| 11 | An improved space-vector-based hysteresis current controller显示文摘 | B H Kown B D Min J H Youn | 1998 | IEEE Trans on Industrial Electronics1998，，： | 1 |
| 12 | Effects of oleoresin-tocopherol combinations on lipid oxidation, off-odor, and color of irradiated raw and cooked pork patties 显示文摘 | Nam K C Ko K Y Min B R Ismail H Lee E J Cordray J Ahn D U | 2007 | Meat Science2007，，： | 1 |
| 13 | Singlet oxygen oxidation for 2-pentylfuran and 2-pentenylfuran formation in soybean oil显示文摘 | Min D B Callison A L Lee H O | 2003 | J Food Sci2003，68，： | 1 |
| 14 | Cloning and analysis of MAGE-1 related genes 显示文摘 | Min D Raymond J B Christopher J | 1994 | Biochem Biophys Res Commun1994，202，1： | 1 |
| 15 | Anti-nucleosome antibody:significance in lupus patients lacking anti-duble stranded DNA antibody显示文摘 | Min D J Kim S J Park S H | 2002 | Clin Exp Rheumatol2002，20，13： | 1 |
| 16 | The multiple depot vehicle routing problem with backhauling显示文摘 | Min H Current J Schilling D | 1992 | Journal of Business Logistics1992，13，： | 1 |
| 17 | Ambient air monitoring of PCDD/Fs and co-PCBs in Gyeonggi-do,Korea显示文摘 | Kim D G Min Y K Jeong J Y | 2007 | Chemosphere2007，67，9： | 1 |
| 18 | Perioperative dynamic alterations in peripheral regulatory T and B cells in patients with hepatocellular carcinoma显示文摘 | Chen T Song D Min Z | 2012 | J Transl Med2012，25，10： | 1 |
| 19 | Frequency-domain elastic full waveform inversion using the new pseudo-Hessian matrix: Experience of elastic Marmousi-2 synthetic da ta显示文摘 | Choi Y Min D J Shin C | 2008 | Bulletin of the Seismological Society of Amer- ica2008，98，5： | 1 |
| 20 | Curve-skeleton properties,applications,and algorithms显示文摘 | Cornea N D Silver D Min P | 2007 | IEEE Transactions onVisualization and Computer Graphics2007，13，3： | 1 |
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