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| 1 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 2 | Catalytic properties of early transition metal nitrides and carbides:n-butane hydrogenolysis,dehydrogenation and isomerization显示文摘 | NEYLON M K CHOI S KWON H CURRY K E THOMPSON L T | 1999 | Appl Catal A1999，183，2： | 1 |
| 3 | Repopu- lation of gamma-irradiated Lewis lung carcinoma by malig- nant cells and host macrophage progenitors显示文摘 | STEPHENS T C CURRIE G A PEACOCK J H | 1978 | Br J Cancer1978，38，5： | 1 |
| 4 | Modulation of North Pa- cific tropical cyclone activity by three phases of ENSO 显示文摘 | KIM H M WEBSTER P J CURRY J A | 2011 | Jour- nal of Climate2011，24，6： | 1 |
| 5 | CD-34Cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures显示文摘 | Anjos-Afonso F Currie E Palmer H G | 2013 | Cell Stem Cell2013，13，2： | 1 |
| 6 | Direct and sensitive miRNA profiling from low-input total RNA显示文摘 | ACH R A CURRY B | 2007 | RNA2007，13，： | 1 |
| 7 | Cell death:the significance of apoptosis显示文摘 | Wyllie A H Kerr J F Currie A R | 1980 | Int Rev Cytol1980，68，1： | 1 |
| 8 | Toward an integrated assessment of the impacts of extreme wind events on Barrow,Alaska显示文摘 | Lynch A H Curry J A Brunner R D | 2004 | Bulletin of American Meteorology Society2004，85，： | 1 |
| 9 | Recovery of in vitro functional activity of platelet concentrates stored at 4℃ and treated with second-messeger effectors 显示文摘 | Connor J Currie LM Allan H | 1996 | Transfusion1996，36，8： | 1 |
| 10 | Cell death: the significance of apoptosis 显示文摘 | WYLLIE A H KERR J F CURRIE A R | 1980 | Int Rev Cytol1980，68，： | 1 |
| 11 | Pattern recognition of the pul- monary manifestations of AIDS on CT scans显示文摘 | Sider L Gabriel H Curry DR | 1993 | Radiographics1993，13，4： | 1 |
| 12 | Perspective on prescribing conjugated estrogens/bazedoxifene for estrogen- deficiency symptoms of menopause: a practical guide 显示文摘 | Palacios S Currie H Mikkola TS | 2015 | Ma- turitas2015，80，4： | 1 |
| 13 | Relationship between early intestinal colonization,mucosal immuno-globulin A production and systemic immune development显示文摘 | Martino DJ Currie H Taylor A | 2008 | Clin Exp Allergy2008，38，1： | 1 |
| 14 | Apoptosis:a basic biol-ogical phenomenon with wide-ranging implications in tissue kinetics显示文摘 | Kerrj F R Wyuie A H Currie A R | 1972 | Br J Cancer1972，26，4： | 1 |
| 15 | Apoptosis: A basic phenomenon with wide-ranging implications in tissue kinetics显示文摘 | KREE J F WYLLIE A H CURRIE A R | 1972 | Br J Cancer1972，26，4： | 1 |
| 16 | Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics显示文摘 | Kerr J F Wyllie A H Currie A R | 1972 | Br J Cancer1972，26，4： | 1 |
| 17 | Effects of chronicnitrogen amendment on production of dissolved organic carbonand nitrogen in forest soils显示文摘 | McDowell W H Currie W S Abert J D e/ al | 1998 | Water Air and Soil Pollution1998，105，12： | 1 |
| 18 | Improved left ventricu- lar mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay 显示文摘 | Kass D A Chen C H Curry C | 1999 | Circula- tion1999，99，12： | 1 |
| 19 | Differential accumulation of mRNA for immediate early genes and heat shock genes in heart after ischemic injury显示文摘 | Plumier JC Robertson H Currie RW | 1996 | J Mol Cell Cardiol1996，28，6： | 1 |
| 20 | Role of IFI16,a member of the interferon-inducible p200-protein family,in prostate epithelial cellular senescence显示文摘 | Xin H Curry J Johnstone RW | 2003 | Oncogene2003，，31： | 1 |
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