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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 3 | Risks and Predictors of Blood Transfusion in Pediatric Patients Undergoing Open Heart Operations显示文摘 | Andrea Székely Zsuzsanna Cserép Erzsébet Sápi Tamás Breuer Csaba A. Nagy Péter Vargha István Hartyánszky András Szatmári András Treszl | 2009 | The Annals of Thoracic Surgery2009，，1： | 2 |
| 4 | Novel targets and new potential:developments in the treatment of inflammation in chronic kidney disease显示文摘 | Csaba P Kovesdy Kamyar Kalantar-Zadeh | | 0，，04： | 1 |
| 5 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 6 | Apoptosis-inducing factor deficiency induces early mitochondrial degeneration in brain followed by progressive multifocal neuropathology显示文摘 | E1 Ghouzzi V Csaba Z Olivier P | 2007 | J Neuropathol Exp Neurol2007，66，9： | 1 |
| 7 | Baker's yeast-mediated synthesis of (R)- and(S)-heteroaryl-ethane-1,2-diols显示文摘 | PAULA V P CSABA P MONICA I T | 2008 | Tetrahedron Asymmetry2008，19，： | 1 |
| 8 | Total and Individual Coronary Artery Calcium Scores as Independent Predictors of Mortality in Hemodialysis Patients显示文摘 | Shantouf Ronney S Budoff Matthew J Ahmadi Naser Ghaffari Arshia Flores Ferdinand Gopal Ambarish Noori Nazanin Jing Jennie Kovesdy Csaba P Kalantar-zadeh Kamyar | 2010 | American Journal of Nephrology2010，，5： | 1 |
| 9 | Use of Pichia pastoris for Production of Recombinant Cytokines显示文摘 | Kevin P M Csaba P Mark D M | 2001 | Interleukin Protocols2001，60，： | 1 |
| 10 | Effects of taxol treatment on the microtubular system and mitochondria of Tetra hymena显示文摘 | Kovács P Csaba G Pallinger E Czaker R | | 0，，： | 1 |
| 11 | Safety aspects oftranscranial direct current stimulation concerning healthy subjects and patients显示文摘 | Csaba P Andrea K Antal A | 2007 | Brain Res Bull2007，72，46： | 1 |
| 12 | Association of activated vitamin D treatment and mortality in chronic kidney disease显示文摘 | Csaba P Kovesdy M D Shahram A | 2008 | Arch Intern Med2008，168，4： | 1 |
| 13 | Gallbladder hypomotility in diabetic polyneuropathy显示文摘 | Tamás T. Várkonyi M.D. Csaba Lengyel M.D. László Madácsy M.D. Borbála Vel?sy M.D. Ph.D. Péter Kempler M.D. Ph.D. D.Sc. Tamás Fazekas M.D. Ph.D. D.Sc. László Pávics M.D. Ph.D. László Csernay M.D. Ph.D. D.Sc. János Lonovics M.D. Ph.D | 2001 | Clinical Autonomic Research2001，，6： | 1 |
| 14 | Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis显示文摘AIM: In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8), the process of regeneration following L-arginine (Arg)-induced pancreatitis is accelerated. In rats that were also diabetic (induced by streptozotocin, STZ), pancreatic regeneration was not observed. The aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats.METHODS: Male Wistar rats were used for the experiments.Diabetes mellitus was induced by administering 60 mg/kg body mass of STZ intraperitoneally (i.p.), then, on d 8, pancreatitis was induced by 200 mg/100 g body mass Argi.p. twice at an interval of 1 h. The animals were injected subcutaneously twice daily (at 7 a.m. and 7 p.m.) with 1 μglkg of CCK-8 and/or 2 IU mixed insulin (300 g/L shortaction and 700 g/L intermediate-action insulin) for 14 d after pancreatitis induction. Following this the animals were killed and the serum amylase, glucose and insulin levels as well as the plasma glucagon levels, the pancreatic mass/body mass ratio (pm/bm), the pancreatic contents of DNA, protein, amylase, lipase and trypsinogen were measured. Pancreatic tissue samples were examined by light microscopy on paraffin-embedded sections.RESULTS: In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein, amylase and lipase vs the rats receiving only CCK-8 treatment. CCK-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities, whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats.CONCLUSION: Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats,the simultaneous administration of exogenous insulin restored this effect. Our results clearly demonstrate that insulin is necessary for the hypertrophic effect of low-doses of CCK-8 following acute pancreatitis. | Péter Hegyi Zoltán RakonczayJr Réka Sári László Czakó Norbert Farkas Csaba Góg József Németh János Lonovics Tamás Takács | 2004 | World Journal of Gastroenterology2004，10，15： | 1 |
| 15 | Inhibition of Hsp 90: a new strategy for inhibiting protein kinases显示文摘 | Csaba S Péter C | 2004 | Biochimica et Biophys Acta2004，1697，12： | 1 |
| 16 | Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes显示文摘 | Pál Pacher Csaba Szabó | 2006 | Current Opinion in Pharmacology2006，，2： | 1 |
| 17 | Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits显示文摘 | Zoltán Jambrik Mariann Gy?ngy?si Péter Hegyi László Czakó Tamás Takács András Farkas Yvette Mándy Csaba Góg Dietmar Glogar Miklós Csanády | 2002 | Intensive Care Medicine2002，，12： | 1 |
| 18 | Poly(ADP-Ribose) Polymerase Inhibition Reduces Reperfusion Injury After Heart Transplantation显示文摘 | Gábor Szabó Susanne B?hrle Nicole Stumpf Karin Sonnenberg éva Szabó Pál Pacher Tamás Csont Richard Schulz Thomas J. Dengler Lucas Liaudet Prakash G. Jagtap Garry J. Southan Christian F. Vahl Siegfried Hagl Csaba Szabó | 2002 | Circulation Research: Journal of the American Heart Association2002，，1： | 1 |
| 19 | Study on the electrodeposition of organic and inorganic thermoelectric materials for composite preparation显示文摘 | Emese Kriván Gábor Bencsik Csaba Janáky Péter S. Tóth Balázs Roósz Gábor Sós Csaba Visy | 2009 | Reaction Kinetics and Catalysis Letters2009，，2： | 1 |
| 20 | Angiotensin Ⅱ-Mediated endothelial dysfunction:role of poly (ADP-ribose) polymerase activation显示文摘 | PáL P ZSUZUANNA Z | 2004 | Mol Med2004，10，： | 1 |
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