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| 1 | Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier显示文摘Androgen deprivation therapy(ADT)has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer(PCa).However,this approach is rarely curative.Recent clinical trials have demonstrated that ADT combined with other agents,notably docetaxel and abiraterone,lead to improved survival.The mechanisms surrounding this improved cancer outcomes are incompletely defined.The response of cancer cells to ADT includes apoptosis and cell death,but a significant fraction remains viable.Our laboratory has demonstrated both in vitro and in vivo that cellular senescence occurs in a subset of these cells.Cellular senescence is a phenotype characterized by cell cycle arrest,senescenceassociated b-galactosidase(SA-b-gal),and a hypermetabolic state.Positive features of cellular senescence include growth arrest and immune stimulation,although persistence may release cytokines and growth factors that are detrimental.Senescent tumor cells generate a catabolic state with increased glycolysis,protein turnover and other metabolic changes that represent targets for drugs,like metformin,to be applied in a synthetic lethal approach.This review examines the response to ADT and the putative role of cellular senescence as a biomarker and therapeutic target in this context. | Tyler Etheridge Shivashankar Damodaran Adam Schultz Kyle A.Richards Joseph Gawdzik Bing Yang Vincent Cryns David F.Jarrard | 2019 | Asian Journal of Urology2019，6，1： | 3 |
| 2 | Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania显示文摘 | Prickaerts J Moechars D Cryns K | 2006 | J Neurosci2006，26，35： | 1 |
| 3 | A genotype-- phenotype correlation for GJB2 (connexin 26) deafness显示文摘 | Cryns K Orzan E Murgia A | 2004 | J Med Genet2004，41，： | 1 |
| 4 | The WFS1 gene, responsible for low frequency sensorineural hearing loss and Wolfram syndrome, is expressed in a variety of inner ear cells显示文摘 | Cryns K Thys S Oka Y | 2003 | Histochemistry and Cell Biology2003，119，3： | 1 |
| 5 | Proteases to die for显示文摘 | Cryns V Yuan Y | 1999 | Genes Dev1999，12，11： | 1 |
| 6 | The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation显示文摘 | Karnradt MC Chert F Cryns VL | 2001 | J Biol Chem2001，276，16： | 1 |
| 7 | Deafness genes and their diagnostic applications显示文摘 | Cryns K Van Camp O | 2004 | Audiol Neurootol2004，9，： | 1 |
| 8 | Proteases to die for显示文摘 | Cryns V Yuan J | 1998 | Genes Dev1998，12，： | 1 |
| 9 | Protease to die for显示文摘 | Cryns V Yuan J | | 0，，11： | 1 |
| 10 | Triple negative breast carci- noma and the basal phenotype: from expression profiling to clinical practice 显示文摘 | Diaz LK Cryns VL Symmans WF | 2007 | Adv Anat Patho12007，14，6： | 1 |
| 11 | Proteases to die for显示文摘 | CRYNS V YUAN J | 1998 | Genes Dev1998，12，： | 1 |
| 12 | The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes显示文摘 | Bialik S Vincent L Cryn S | 1999 | Circ Res1999，85，： | 1 |
| 13 | Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies显示文摘 | Toft DJ Cryns VL | 2011 | Mol Endocrinol2011，25，2： | 1 |
| 14 | The small heat shock protein aB-crystallin negatively regulates cytochrome c- and caspase-8- dependent activation of caspase-3 by inhibiting its autoproteo- lytic maturation显示文摘 | Kamradt MC Chen F Cryns VL | 2001 | J Biol Chem2001，276，16： | 1 |
| 15 | Proteases to die for显示文摘 | Cryns V Yuan J | 1998 | Genes Dev1998，12，11： | 1 |
| 16 | The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8- dependent activation of caspase-3 by inhibiting its autoproteolytic maturation显示文摘 | Kamradt MC Chen F Cryns VL | 2001 | J Biol Chem2001，276，16： | 1 |
| 17 | The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogen- ic differentiation by inhibiting caspase-3 activation 显示文摘 | Kamradt MC Chert F Cryns VL | 2002 | J Biol Chem2002，277，38： | 1 |
| 18 | Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis显示文摘 | Chen F Arseven O K Cryns V L | 2004 | J Biol Chem2004，279，27： | 1 |
| 19 | A genotype--phenotype correlation for GJB2 (connexin 26) deafness显示文摘 | Cryns K Orzan E Murgia A | 2004 | J Med Genet2004，41，： | 1 |
| 20 | A genotype-phenotype correlation for GJB2 (connexin 26) deafness显示文摘 | Cryns K Orzan E Murgia A | 2004 | Med Genet2004，41，： | 1 |
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