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| 1 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 2 | The role of B lympho- cyte stimulator (BLyS) in systemic lupus erythematosus 显示文摘 | Cancro MP Cruz DP Khamashta MA | 2009 | J Clin Invest2009，119，5： | 1 |
| 3 | Flooding effects on phosphorus dynamics in an Amazonian mangrove forest, Northern Brazil 显示文摘 | MENDOZA U N DA CRUZ C C MENEZES MP | 2012 | Plant and Soil2012，353，： | 1 |
| 4 | Depression as a determinant of quality of life in patients with chronic disease: data from Brazil显示文摘 | Cruz LN Fleck MP Polanczyk CA | 2010 | Soc Psychiat EpidemioI2010，45，10： | 1 |
| 5 | Preliminary Study of Propyl Bromide Exposure among New Jersey Dry Cleaners as a Result of a Pending Ban on Perchloroethylene显示文摘 | Blando JD Schill DP De La Cruz MP | 2010 | J Air Waste Manag Assoc2010，60，9： | 1 |
| 6 | Duloxetine HCL (Cymbalta) forthe treatment of depression, neuropathic pain, fibromyalgia, and stress urinary incontinence 显示文摘 | CRUZ MP GONZALES ME JAC OBS J | 2006 | Drug Forecast2006，31，2： | 1 |
| 7 | Duloxetine HCI(Cymbalta) for the treatment of depression, neuropathic pain,fibromyalgia, and stress urinary incontinence显示文摘 | CRUZ MP GONZALES ME JACOBS J | 2006 | Drug Forecast2006，31，2： | 1 |
| 8 | Molecular architecture of the vanilloid receptor显示文摘 | Antonio FM Carolina GM Cruz MP | 2004 | Eur J Biochem2004，271，： | 1 |
| 9 | Duloxetine HCL (Cymbalta)for the treatment of depression,neuropathic pain,fibromyalgia,and stress urinary incontinenee显示文摘 | Cruz MP Gonzales ME Jacobs J | 2006 | Drug Forecast2006，31，2： | 1 |
| 10 | Measurement of aortic valve annulus using different cardiac imaging techniques in transcatheter aortic valve implantation: agreement with finally implanted prosthesis size 显示文摘 | Mesa Rubio D Suarez de Lezo Cruz Conde J Alvarez- Osorio MP | 2011 | Echocardiography2011，28，： | 1 |
| 11 | The role of B lymphocyte stimulator(BLy S)in systemic lupus erythemat osus显示文摘 | Cancro MP D'Cruz DP Khamashta MA | 2009 | J Clin Invest2009，119，5： | 1 |
| 12 | Depression as a determinant of quality of life in patients with chronic disease: data from Brazil显示文摘 | Cruz LN de Almeida Fleck MP Polanczyk CA | 2010 | Social psychiatry and psychiatric epidemiology2010，45，10： | 1 |
| 13 | Guanfacine extended-release tablets ( Intuniv) , anonstimulant selective alpha2A-adrenergic receptor agonist for at-tention-deficit/hyperactivity disorder显示文摘 | CRUZ MP | 2010 | P T2010，35，8： | 1 |
| 14 | Treatment of symptomatic focal nodular hyperplasia by arterial embolization 显示文摘 | Gómez García MP Cruz González I Pena Baranda B | 2014 | Cir Esp2014，92，2： | 1 |
| 15 | Duloxetine HCI (Cymbalta) for the treatment of depression, neuropathic pain, fibro myalgia and stress urinary incontinence显示文摘 | Cruz MP Gonzales ME Jacobs J | 2006 | Drug Forecast2006，31，2： | 1 |
| 16 | Determination of the efficacy of two building decontamination strategies by surface sampling with culture and quantitative PCR analysis显示文摘 | Buttner MP Cruz P Stetzenbach LD | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 17 | Detection and enumeration of airborne biocontaminants显示文摘 | Stetzenbach LD Buttner MP Cruz P | 2004 | Current Opinion in Biotechnology2004，15，： | 1 |
| 18 | Duloxetine HCI (Cymbalta) for the treatment of depression, neuropathic pain, libromyalgia and stress urinary ineontinence 显示文摘 | Cruz MP Gonzales ME Jaeobs J | 2006 | Drug Forecast2006，31，2： | 1 |
| 19 | Pinheiro microbial conversion of steroid compounds: Recent develop- ments显示文摘 | FERNANDES MP CRUZ A ANGELO- VA B | 2003 | Enzyme and Microbial Tech- nology2003，32，： | 1 |
| 20 | The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus显示文摘 | Cancro MP D'Cruz DP Khamashta MA | 2009 | J Clin Invest2009，119，5： | 1 |
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