维普中文期刊产品整合服务
14篇 您的检索式:作者名="Cregor"
    题名 作者 年代 出处 被引量
1Ultrasonography-guided fine needle aspiration for the assessment of cervical metastases显示文摘Knappe M Louw M Cregor RT 2000Arch Otolaryngol Head Neck Surg2000,126,9:1
2The surgical management of obstruction and perforantion of the left colon 显示文摘Mc Cregor JR Dwyer DJ 1993Surg Gynecol Obstet1993,17,:1
3Correlation of survivin mRNA detection with histologic diagnosis in normal endomet rium and endomet rial carcinoma显示文摘Lehner R Enomoto T Me Cregor J A 2002Acta Obstet Gynecol Scand2002,81,2:1
4Speed-strength preparation of future champions显示文摘Vorkhoshanskj T Cregor S M 1983Soviel Sports Review1983,18,4:1
5The evaluation of the surgical manage- ment of never root compression in patients with low back pain 显示文摘Mc Cregor AH Hughes SP 2002Spine2002,27,:1
6Dislocation after total hip replacement in: ochsmer PE 显示文摘Cregor K 2002Total hip replacement 1 st end Berlin springer2002,,:1
7The surgieal management of obstruction and perforation of the lefe colon显示文摘Mc Cregor JR O'Dwyer DJ 1993Surg Gynecol Obstet1993,17,7:1
8The surgieal management of obstruction and perforation of the lefe colon显示文摘Mc Cregor JR O'Dwyer DJ 1993Surg Gynecol Obstet1993,17,7:1
9The surgical management of ob struction and perforation of the left colon显示文摘Mc Cregor J R O Dwyer D J 1993Surg Gynecol Obstet1993,177,2:1
10Culex ABS Part Ⅰ:Introduction to Automated Blood Sampling 显示文摘PETERS S HAMPSCH J CREGOR M 2000Cur Sep2000,18,:1
11Culex Automated Blood Sampler Part Ⅱ: Managing Freely-Moving Animals and Monitoring their Activity 显示文摘BOHS C CREGOR M GUNARATNA G 2000Cur Sep2000,18,:1
12Culex ABS Part Ⅰ:Introduction to automated blood sampling显示文摘Peter S Hampsch J Cregor M 0,,04:1
13Culex automated blood sampler part Ⅱ:Managing freely-moving animals and monitoring their activity显示文摘Bohs C Cregor M Gunaratna G 0,,04:1
14Reversal of the diabetic bone signature with anabolic therapies in mice显示文摘The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood;and antiresorptive agents,the current standard of care,do not restore the weakened bone architecture.Herein,we reveal the diabetic bone signature in mice at the tissue,cell,and transcriptome levels and demonstrate that three FDA-approved bone-anabolic agents correct it.Diabetes decreased bone mineral density(BMD)and bone formation,damaged microarchitecture,increased porosity of cortical bone,and compromised bone strength.Teriparatide(PTH),abaloparatide(ABL),and romosozumab/anti-sclerostin antibody(Scl-Ab)all restored BMD and corrected the deteriorated bone architecture.Mechanistically,PTH and more potently ABL induced similar responses at the tissue and gene signature levels,increasing both formation and resorption with positive balance towards bone gain.In contrast,Scl-Ab increased formation but decreased resorption.All agents restored bone architecture,corrected cortical porosity,and improved mechanical properties of diabetic bone;and ABL and Scl-Ab increased toughness,a fracture resistance index.Remarkably,all agents increased bone strength over the healthy controls even in the presence of severe hyperglycemia.These findings demonstrate the therapeutic value of bone anabolic agents to treat diabetes-induced bone disease and suggest the need for revisiting the approaches for the treatment of bone fragility in diabetes.Silvia Marino Nisreen Akel Shenyang Li Meloney Cregor Meghan Jones Betiana Perez Gaston Troncoso Jomeeka Meeks Scott Stewart Amy YSato Intawat Nookaew Teresita Bellido 2023Bone Research2023,11,2:0
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费