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| 1 | The seasonal variations of δ^(18)O , Cl^- , Na^+ ,NO_3^- and Ca^(2+) in the snow and firn recovered from Princess Elizabeth Land, Antarctica显示文摘Snow and firn samples recovered from two snow pits (2.5 and 4.5m deep) and one 50-m firn core along the route of the 1996/1997 Chinese First Antarctic Inland Traverse Expedition in Princess Elizabeth Land, East Antarctica, have been measured for chemical composition and oxygen isotope ratio. In the two snow pits, the variations of NO3- are partly in phase with that of δ18O, while the variations of Cl- and Na+ are in inverse phase with that of δ18O. | LI Zhongqin, ZHANG Mingjun, QIN Dahe, XIAO Cunde, TIAN Lide KANG Jiancheng and LI Jun Lanzhou Institute of Glaciology and Geocryology , Chinese Academy of Sciences , Lanzhou 730000, China Chinese Institute of Polar Research, Shanghai 200129, China Antarctic CRC and Australian Antarctic Division , Hobart, Australia Corresponding author | 1999 | Chinese Science Bulletin1999，44，24： | 17 |
| 2 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 3 | FT Ⅰ, a novel positive myeloid-lineage-specific transcription regulatory element within the mouse myeloperoxidase gene enhancer, En 1显示文摘FT Ⅰ (AAAAGGGGAAGCAGAG), a poly purine ele-ment within the myloid-lineage specific enhancer (En 1) of the mouse myeloperoxidase gene [1, 2] has been fur-ther characterised. 1, FT Ⅰ functions as a myeloid-lineage specific transcription regulatory element; 2, WEHI 3BD+ cells have higher binding activity to FT Ⅰ and express the proteins which could form the unique DNA-protein com-plex(es) of FT Ⅰ;. 3, The essential sequence for the specific DNA-protein interactions of FT Ⅰ is AAAAGGGGAAGC; 4, South-western analysis in conjunction with the compe-tition assay of the proteins binding to FT Ⅰ, has revealed a 28 kd protein in WEHI 3BD+ cells that displays the properties of the putative transcription factor which acts through FT Ⅰ. These new findings have demonstrated both the functional myeloid-lineage specificity and the novelty of FT Ⅰ. | ZHU JINGDE (CRC Department of Medical Oncology, CRC Beat son Laboratories, Glasgow University, Garscube Estate, Switchback Road, Glasgow G61 1BD, United Kngdom. Tel: 44141942 9361 Fax: 44141 330 4127. e-mail:gpma66@udcf. gla. ac. uk ) | 1995 | Cell Research1995，5，1： | 4 |
| 4 | Antiproteinuric treatment reduces urinary loss of vitamin D - binding protein but does not affect vitamin D status in patients with chronic kidney disease显示文摘 | Doorenbos CRC de Cuba MM Vogt L | 2012 | The Journal of steroid biochemistry and molecular bi- ology2012，128，1： | 1 |
| 5 | The evolution of multiple sclerosis lesins on serial MR显示文摘 | Guttmann CRC Ahn SS Hsu L | 1995 | AJNR1995，16，6： | 1 |
| 6 | Knee joint functional range of movement prior to and following total knee arthroplasty measured using flexible electrogoniometry显示文摘 | Myles CM Rowe PJ Walker CRC | 2002 | Gait Posture2002，16，： | 1 |
| 7 | The oncologic benefit of high ligation of the inferior mesenteric artery in the surgical treatment of rectal or sigmoid colon cancer显示文摘 | CC Chin CYY R Tang CRC | 2008 | Int J Colorectal Dis2008，23，： | 1 |
| 8 | Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells显示文摘 | CRC van Roeyen T Ostendorf B Denecke | 2006 | Kidney Int2006，69，8： | 1 |
| 9 | Knee joint functional range of movement prior to and following total knee arthroplasty measured using flexible electrogoniometry显示文摘 | Myles CM Rowe PJ Walker CRC | 2002 | Gait and Posture2002，16，： | 1 |
| 10 | Pro-fibrogenic po- tential of PDGF-D in liver fibrosis显示文摘 | Kamphorst EB Roeyen CRC Ostendorf T | 2007 | Journal of Hepatology2007，46，6： | 1 |
| 11 | The evolution of multiple scle rosis lesions on serial MR显示文摘 | Guttmann CRC Ahn SS Hsu L | 1995 | AJNR1995，16，： | 1 |
| 12 | Policyclic aromatic hydrocarbons in brazilian vegetables and fruits显示文摘 | Monica CRC Maria CFT | 2003 | Food Control2003，14，： | 1 |
| 13 | Rev Food Technol显示文摘 | Balassa L L Fanger G O CRC Crit | 1971 | 7(3):245~2611971，7，3： | 1 |
| 14 | Effect of pre-fer-mentation on the production of cutinase by a recombinant Saccha-romyces cerevisiae 显示文摘 | CALADO CRC MONTEIRO S CABRAL J | 2002 | J Biosci Bioeng2002，93，4： | 1 |
| 15 | Albumin-loaded PLA and PLGA microspheres:in vitro evaluation显示文摘 | Crc -V Jalsenjak I | 1999 | Boll Chim Farm1999，138，： | 1 |
| 16 | In vitro evalua- tion of the antimicrobial activity of endodontic sealers 显示文摘 | Miyagak DC Carvalho EMOF Robazza CRC | 2006 | Braz Oral Res2006，20，4： | 1 |
| 17 | ALow-order Model of Two-dimensional Fluid Dynamics on the Surface of a Sphere显示文摘ALow-orderModelofTwo-dimensionalFluidDynamicsontheSurfaceofaSphereMozhengWei(CRCforSouthernHemisphereMeteorology,CSIRODivisio... | Mozheng Wei(CRC for Southern Hemisphere Meteorology,CSIRO Division of Atmospheric Research,Private Bag No.l,Mordialloc 3195,Australia ) | 1996 | Advances in Atmospheric Sciences1996，13，1： | 0 |
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