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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | 人工肩关节表面置换术的应用显示文摘 | 鲁宁 Edward V Craig | 2010 | 中华关节外科杂志(电子版)2010，4，5： | 8 |
| 3 | Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study显示文摘AIM: To study the effectiveness of melatonin vs placebo in children with functional dyspepsia(FD).METHODS: The study was conducted as a double blind, randomized, placebo controlled crossover trial. Subjects were aged 8-17 years and diagnosed with FD based on Rome Ⅲ criteria. All subjects had failed to respond to 4 wk of acid suppression. Subjects receive a continuous two weeks of placebo and a continuous two weeks of melatonin in an order blinded to the participant and the study team. A Global Clinical Score was obtained to assess changes in abdominal pain. Pain was self-reported to be worse(grade 1), no change(grade 2), moderate improvement(grade 3), good(grade 4; minimal pain and not interfering with daily activities), or excellent(grade 5; no pain), respectively. A positive clinical response was defined as a grade 3 or greater response. Subjects wore an actigraph to assess sleep during a one week baseline period and during each treatment period. Subjects' sleep latency and total sleep time were recorded throughout the duration of the study. RESULTS: Fourteen subjects were enrolled and 12 completed the study. One withdrew prior to starting both melatonin and placebo and the other before starting melatonin. A positive clinical response(grade 3-5) was achieved in 42% of subjects on melatonin vs 50% of subjects on placebo(NS). Effect size was calculated and revealed a Cohen's D of 0.343 which demonstrates a medium effect favoring placebo. A grade 4 or grade 5 response was seen in 4 patients on melatonin and 5 patients on placebo. Baseline sleep parameters were in the healthy range with the longest sleep latency being just over 20 min(mean 7.46 ± 8.53 min) and the shortest sleep duration just over 7 h(mean 10.09 ± 2.72 h). The mean latency did not differ between periods of treatment with melatonin as compared to placebo(4.48 ± 6.45 min vs 3.58 ± 4.24 min; NS). The mean sleep duration did not differ between periods of treatment with melatonin as compared to placebo(9.90 ± 3.53 h vs 9.41 ± 2.70 h; NS).CONCLUSION: Melatonin does not appear to have efficacy in relieving pain in unselected pediatric FD. Future studies should consider FD subtypes, pathophysiologic mechanisms, and baseline sleep disturbances. | Katherine Zybach Craig A Friesen Jennifer V Schurman | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 6 |
| 4 | Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia显示文摘There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining 'anti-inflammatory' medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD. | Craig A Friesen Jennifer V Schurman Jennifer M Colombo Susan M Abdel-Rahman | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 5 | Present state and future challenges in pediatric abdominal pain therapeutics research: Looking beyond the forest显示文摘At the present time, it is nearly impossible to treat pediatric functional gastrointestinal disorders associated with pain in an evidence based fashion. This is due to the overall lack of controlled studies and, even more importantly, the complexity of the contributors to disease phenotype which are not controlled or accounted for in most therapeutic trials. In this manuscript, we review the challenges of defining entry criteria, controlling for the large number of biopsychosocial factors which may effect outcomes, and understanding pharmacokinetic and pharmacodynamic factors when designing therapeutic trials for abdominal pain in children. We also review the current state of pediatric abdominal pain therapeutics and discuss trial design considerations as we move forward. | Craig A Friesen Jennifer V Schurman Susan M Abdel-Rahman | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 3 |
| 6 | Symptoms and Subtypes in Pediatric Functional Dyspepsia: Relation to Mucosal Inflammation and Psychological Functioning显示文摘 | Jennifer V Schurman Meenal Singh Vivekanand Singh Nancy Neilan Craig A Friesen | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，3： | 2 |
| 7 | 显示文摘 | Tropepe V Morshead CM | 1996 | J Neurosci1996，16，： | 1 |
| 8 | In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain显示文摘 | Craig CG Tropepe V Morshead CM | 1996 | J Neurosci1996，16，8： | 1 |
| 9 | Replacing hexavalent chromium in passivation on zinc plated parts显示文摘 | Paul C Craig V | 2004 | Powder Coating2004，，9： | 1 |
| 10 | Micellar electrokinetic capillary chromatographic determination of artificial sweeteners in low-Joule soft drinks and other foods显示文摘 | CATHERINE O T CRAIGE TRENERRY V | 1995 | J Chromatogr: A1995，694，： | 1 |
| 11 | Tamoxifen, raloxifene and the prevention of breast cancer显示文摘 | Craig Jordan V | 2002 | Minerva Endocrinol2002，27，2： | 1 |
| 12 | Shear-dependent boundary slip in an aqueous Newtonian liquid显示文摘 | Craig V S J Neto C Williams D R M | 2001 | Physical Review Letters2001，87，05： | 1 |
| 13 | Replacing hexavalent chromium显示文摘 | Paul C Craig V | 2000 | Plating and Surface Finishing2000，88，2： | 1 |
| 14 | MAP3Ks as central regulators of cell fate during development 显示文摘 | Evisabel A Craig Mark V Stevens Richard R Vaillancourt | 2008 | Developmental Dynamics2008，237，11： | 1 |
| 15 | FAK association with multiple signal proteins mediates pressure-induce colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway显示文摘 | Thamilselvan V Craig DH Basson MD | 2007 | The FASEB Journal2007，21，1： | 1 |
| 16 | Gender differences in perceptions of web-based shopping显示文摘 | CRAIG V S CHRISTIE L C | | 0，，08： | 1 |
| 17 | Treatment of deepcarious lesions by complete excavation or partial removal : a criti-cal review显示文摘 | Thompson V Craig RG Curro FA | 2008 | J Am Dent Assoc2008，139，6： | 1 |
| 18 | FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway显示文摘 | Thamilselvan V Craig DH Basson MD | 2007 | FASEB J2007，21，8： | 1 |
| 19 | Epigenetic si- lencing of microRNA-203 dysregulates ABL1 expression and drives Helieohaeter-associated gastric lymphomagen- esis 显示文摘 | Craig V J Cogliatti SB Rehrauer H | 2011 | Cancer Res2011，71，10： | 1 |
| 20 | Guideline for prevention of catheter-associated urinary tract infection 2009显示文摘 | Carolyn V Craig A Rajender K | 2010 | Infec- tion Control and Hospital Epidemiology2010，31，4： | 1 |
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