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| 1 | IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location显示文摘AIM: To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-α and the interleukin (IL)-10 in childhood Crohn’s disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes. METHODS: Ten variants in GR, TNF-α and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin. RESULTS: For the GR polymorphisms (R23K and N363S) and IL-10 variants in the 5’flanking region (-1082 G > A, -819 T > C and -592 A > C), no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians (GCC, ACC and ATA) and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of fi ve polymorphisms in the promoter region of the TNF-α gene (-1031 T > C, -863 A > C, -857 T > C, -308 A > G and -238 A > G) revealed a significant overrepresentation of homozygous -1031 CC among CD patients (OR = 9.9) and an association with the colonic location. For TNF-α, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.CONCLUSION: This is one of the fi rst studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD. | Rocio Sanchez Emile Levy Florin Costea Daniel Sinnett | 2009 | World Journal of Gastroenterology2009，15，30： | 9 |
| 2 | Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Delhaye A. Tringali J. Dominguez-Munoz J.-W. Poley M. Arvanitaki G. Costamagna F. Costea J. Devière P. Eisendrath S. Lakhtakia N. Reddy P. Fockens T. Ponchon M. Bruno | 2012 | Endoscopy2012，，08： | 5 |
| 3 | Normal and ma- lignant epithelial cells with stem - like properties have an extended G2 cell cycle phase associated with apoptotic resitance显示文摘 | Harper LJ Costea DE Gammon L | 2010 | BMC Cancer2010，10，： | 1 |
| 4 | Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline显示文摘 | J.-M. Dumonceau M. Delhaye A. Tringali J. Dominguez-Munoz J.-W. Poley M. Arvanitaki G. Costamagna F. Costea J. Devière P. Eisendrath S. Lakhtakia N. Reddy P. Fockens T. Ponchon M. Bruno | 2012 | Endoscopy2012，，08： | 1 |
| 5 | Thermoxidative decomposition of some polysulfones under dynamic conditions of heating显示文摘 | VASILE C COSTEA E PASCU M C | 1998 | J of Therm Anal1998，52，2： | 1 |
| 6 | Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts l Possible effects of KATP channel activation显示文摘 | Costeas C Deruyter B | 2002 | Circulation2002，105，19： | 1 |
| 7 | Molecular and functional characterization of the Salmonella invasion gene invA : Homology of InvA to members of a new protein family显示文摘 | Galan J E Ginocchio C Costeas P | 1992 | Journal of Bacteriology1992，174，13： | 1 |
| 8 | Combining sev- eral polymorphisms of thymidylate synthase gene for pharmacogenetic analysis显示文摘 | KRAJINOVIC M COSTEA I PRIMEAU M | 2005 | Pharmacogenomics J2005，5，6： | 1 |
| 9 | Surgical man agement of renal hyperparathyroidism: a preliminary series report显示文摘 | Diaconescu MR Glod M Costea I | 2011 | ehirurgia (Bucur)2011，106，： | 1 |
| 10 | Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia显示文摘 | Laverdiere C Chiass on S Costea I | 2002 | Blood2002，100，10： | 1 |
| 11 | The influence of cyclin D1 (CCND1) 870A > G polymorphism and CCND1 - thy- midylate synthase (TS) gene- gene interaction on the outcome of childhood acute lymphoblastic leukaemia 显示文摘 | COSTEA I MOGHRABI A KRAJINOVIC M | 2003 | Pharmacogeneties2003，13，9： | 1 |
| 12 | Combining several polymorphisms of thymidylate synthase gene for pharmacogenetie analysis显示文摘 | Krajinovic M Costea Ⅰ Primean M Dulueq S Moghrabi A | 2005 | Pharmacogenomics J2005，5，6： | 1 |
| 13 | Fibroblast control on epithelial differentiation is gradually lost during in vitro tumor progression显示文摘 | Costea DE Johannessen AC Vintermyr OK | 2005 | Differentiation2005，73，4： | 1 |
| 14 | Tissue engineering of oral dysplasia显示文摘 | Gaballah K Costea DE Hills A | 2008 | J Pathol2008，215，3： | 1 |
| 15 | Large thigh liposarcoma--diagnostic and therapeutic features显示文摘 | Costea R Vasiliu E Zarnescu NO | 2011 | J Med Life2011，4，2： | 1 |
| 16 | Molecular and functionalcharacterization of the Salmonella invasion gene invA: homology ofinvA to members of a new protein family显示文摘 | GALAN J E GINOCCHIO C COSTEAS P | 1992 | Journal of Bacteriology1992，174，13： | 1 |
| 17 | Optimization of direct Camot cycle显示文摘 | Feidt M Costea M Petre C | 2007 | Appl Thermal Engng2007，27，56： | 1 |
| 18 | Polymorphism GSOA in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia显示文摘 | Laverdiere C Chiasson S Costea I | 2002 | Blood2002，100，10： | 1 |
| 19 | Combining several polymorphisms of thymidylate synthase gene for pharmacogcnetic analysis显示文摘 | Kxajinovic M Costea I Primeau M | 2005 | Pharmacogenomics J2005，5，6： | 1 |
| 20 | Using the alternative five factor personality model to explain driving anger expression显示文摘 | SARBESCU P COSTEA I RUSU S | 2012 | Proeedia-Social and Behavioral Sciences2012，33，： | 1 |
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