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| 1 | Pacemaker therapy in very elderly patients: survival and prognostic parameters of single center experience显示文摘Background Permanent pacing is the therapy of choice for treating severe and/or symptomatic bradyarrhythmias. The number of very elderly patients receiving pacemakers is increasing and little is known about survival in this specific subgroup. This study is aimed at assessing the actual survival of patients requiring pacing therapy at age > 85 years and investigating variables associated with death. Methods Between 2010 and 2017, 572 patients aged ≥ 85 years underwent pacemaker implantation for conventional bradycardia indications in Department of Cardiology, S. Chiara Hospital, Italy. Results Thirty percent of patients were ≥ 90-year-old and comorbidities were frequent. Fifty-seven percent of patients required pacing for prognostic reasons(acquired atrioventricular block), and the remaining for relief of bradycardia symptoms. A dual-chamber pacemaker was implanted in 34% of patients. The 5-year survival was 45%(standard error: 3%), and the 8-year survival was 26%(standard error: 4%). The risk of death was similar in patients who received pacemaker for symptom relief and for prognostic reasons in the overall population(HR = 1.19, 95% CI: 0.93–1.52, P = 0.156), as well as in the ≥ 90-year-old group(HR = 1.39, 95% CI: 0.92–2.11, P = 0.102). At multivariate analysis, following variables were associated with death: higher age, lower ejection fraction, dementia/dysautonomia and diagnosis of cancer. The pacing indication and the implantation of a single chamber pacemaker were not associated with worse prognosis. Conclusions This study showed a good life expectancy in patients aged ≥ 85 years who received a pacemaker. Strong risk factors for all-cause death were non-cardiac. Pacemaker therapy seems a clinically effective therapeutic option to improve survival and to control bradyarrhythmia-related symptoms in very elderly patients. | Massimiliano Marini Marta Martin Michela Saltori Silvia Quintarelli Filippo Zilio Fabrizio Guarracini Alessio Coser Sergio Valsecchi Roberto Bonmassari | 2019 | Journal of Geriatric Cardiology2019，16，12： | 3 |
| 2 | Executive function profiles of children with attention deficit hyperactivity disorder显示文摘 | SHALLCE T I M MARZOCCHI G M COSER S | 2002 | Developmental Neurochopsychology2002，21，1： | 1 |
| 3 | Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray显示文摘 | Coser KR Chesnes J Hur J | 2003 | Proc Natl Acad Sci USA2003，100，13： | 1 |
| 4 | Auditory brainstem response in premature and full-term ehildren显示文摘 | Sleifer P Costa SSD Coser PL | 2007 | International Journal of Pediatric Otorhinolaryngology2007，71，： | 1 |
| 5 | P300 audito- ry evoked potential latency in elderly显示文摘 | COSER M J COSER P L PEDROSO F S | 2010 | Braz J Otorhinolar- yngol2010，76，3： | 1 |
| 6 | P300 auditory evoked potential latency in elderly 显示文摘 | Coser MJ Coser PL Pedroso FS | 2010 | Braz J Otorhinolaryngol2010，76，3： | 1 |
| 7 | Auditory brainstem response in premature and full-term children显示文摘 | Sleifer P Da CS Coser PL | 2007 | Int J Pediatr Otorhinolaryngol2007，71，： | 1 |
| 8 | Prevalence of TEL/AML1 fusion gene in Brazilian pediatric patiens with acute lymphoblastic leukemia显示文摘 | Zen PRG Lima MC Coser VM | 2004 | Cancer Genet Cytogenet2004，151，： | 1 |
| 9 | Importance of dosage standardization for interpreting transcriptomal signature profiles:Evidence from studies of xenoestrogens显示文摘 | Shioda T Chesnes J Coser KR | 2006 | Proc Natl Acad Sci2006，103，12： | 1 |
| 10 | Executive function profile of children with attention deficit hyperactivity disorder显示文摘 | Shallice T Marzocchi GM Coser S | 2002 | Developmental Neuropsychology2002，21，1： | 1 |
| 11 | Social conflict and the theory of social change显示文摘 | Lewis A Coser | | 0，，37： | 1 |
| 12 | Endoscopic management of postoperative stapled colorectal anastomosis hemorrhage显示文摘 | R. O. Perez A. Sousa C. Bresciani I. Proscurshim R. Coser D. Kiss A. Habr-Gama | 2007 | Techniques in Coloproctology2007，，1： | 1 |
| 13 | Executive function profile of children with attention deficit hyperactivity disorder显示文摘 | Shallice T Marzocchi GM Coser S | 2002 | Develop Neuropsycho12002，21，1： | 1 |
| 14 | Microbial bio- mass nitrogen in cerrado soil with nitrogen fertilizer application 显示文摘 | Coser T R Ramos M L G Amabile R F | 2007 | Pesquisa Agropecu6ria Brasileira2007，42，3： | 1 |
| 15 | The apparent excess of acute promyelocytic leukemia in infant acute leukemias in Brazil 显示文摘 | Mendes WL Coser VM Ramos G | 2004 | Haematologica2004，89，： | 1 |
| 16 | Executive function profile of children with attention deficit hyperactivity disorder显示文摘 | Shallice T Marzocchi GM Coser S | 2002 | Dew Neuropsychol2002，21，1： | 1 |
| 17 | Executive function profiles of children with attention deficit hyperactivity disorder显示文摘 | Shallice T Marzocchi GM Coser S | 2002 | Developmental Neurochopsychology2002，21，1： | 1 |
| 18 | Executive function profiles of children with attention deficit hyperactivity disorder显示文摘 | Shallice T Marzocchi GM Coser S | 2002 | Dev Neuropsychol2002，21，： | 1 |
| 19 | Human papillomavirus detection and typing using a nested-PCR-RFLP assay显示文摘 | Coser J Boeira Tda R Fonseca AS | 2011 | Braz J Infect Dis2011，15，5： | 1 |
| 20 | Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor ct protein in MCF-7 cells require the CSK c-Src tyrosine kinase 显示文摘 | Yeh WL Shioda K Coser KR | 2013 | PLoS ONE2013，8，60： | 1 |
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