|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile显示文摘AIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively. METHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16INK4A protein immunostaining of all the specimens was conducted. RESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases(13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country. CONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. | Andres Castillo Francisco Aguayo Chihaya Koriyama Miyerlandi Torres Edwin Carrascal Alejandro Corvalan Juan P Roblero Cecilia Naquira Mariana Palma Claudia Backhouse Jorge Argandona Tetsuhiko Itoh Karem Shuyama Yoshito Eizuru Suminori Akiba | 2006 | World Journal of Gastroenterology2006，12，38： | 11 |
| 2 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 3 | Helicobacter pylori -Induced Chronic Gastritis and Assessing Risks for Gastric Cancer显示文摘 | Gonzalo Carrasco Alejandro H. Corvalan N. Ananthakrishnan | 2013 | <journal-title>Gastroenterology Research and Practice2013，，： | 2 |
| 4 | Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer 显示文摘 | LaRochelle W J Jeffers M Corvalan JR | 2002 | Cancer Res2002，62，9： | 1 |
| 5 | Epstein-Barr virus in gastric carcinoma is associated with location in the cardia and with a diffuse histology a study in one area of Chile 显示文摘 | Koriyama C Akiba S | 2001 | Int J Cancer2001，94，4： | 1 |
| 6 | Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy显示文摘 | Yang XD Jia XC Corvalan JR | 1999 | Cancer Res1999，59，： | 1 |
| 7 | Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in hu- man cancer显示文摘 | LaRochelle W J Jeffers M Corvalan JR | 2002 | Cancer Res2002，62，9： | 1 |
| 8 | Development of ABXEGF, a fully human anti-EGF receptor monoclonal antibody for cancer therapy显示文摘 | Yang X D Jia X C Corvalan J R | 2001 | Crit Rev Oncol Hematol2001，38，： | 1 |
| 9 | Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy显示文摘 | Yang XD Jia XC Corvalan JR | 1999 | Cancer Res1999，59，6： | 1 |
| 10 | Platele-de-rivde growth factor D,tum origenicity in m ice and dysregu-lated expression in hum an cancer显示文摘 | LaRochelleW J JeffersM Corvalan JR | | 0，，9： | 1 |
| 11 | Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer 显示文摘 | Carrasco G Corvalan AH | 2013 | Gastroen- terol Res Pratt2013，2013，39： | 1 |
| 12 | How can the Developmental Origins of Health and Disease (DOHaD) hypothesis contribute to improving health in developing countries显示文摘 | Uauy R Kain J Corvalan C | 2011 | Am J Clin Nutr2011，94，61： | 1 |
| 13 | Gastric permeability is not increased in children colonized by CagA-positive strains of Helicobacter Pylori 显示文摘 | Gotleland M Corvalan A Sarmiento F | 2001 | Dig Liver Dis2001，33，9： | 1 |
| 14 | Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemo-therapy显示文摘 | Yang X D Jia X C Corvalan J R | 1999 | Cancer Res1999，59，6： | 1 |
| 15 | Development of ABX EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy显示文摘 | Yang X D Jia X C Corvalan J R | 2001 | Crit Rev Oncol Hematol2001，38，1： | 1 |
| 16 | Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells显示文摘 | Corvalan L A Araya R Branes M C | 2007 | J Cell Physiol2007，211，3： | 1 |
| 17 | Gastric Permeability is not increased in children colonized by CagA-positive strains of Helicobacter Pylori显示文摘 | Gotleland M Corvalan A Sarmiento F | 2001 | Dig Liver Dis2001，33，9： | 1 |
| 18 | Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice 显示文摘 | Mendez MJ Green LL Corvalan JFR | 1997 | Nat Genet1997，15，： | 1 |
| 19 | Helicobacter pylori-induced chronic gastritis and assessing risks for gastric cancer 显示文摘 | Carrasco G Corvalan A H | 2013 | Gastroenterology research and practice2013，1，1： | 1 |
| 20 | Development of ABX-EGF,a fully human anti-EGF receptor monoclonal antibody, for cancer therapy显示文摘 | Yang XD Jia XC Corvalan JR | 2001 | Hematology2001，38，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员