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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer显示文摘The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them. | Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania Napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani | 2016 | World Journal of Gastroenterology2016，22，28： | 6 |
| 3 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 4 | Hepatocyte transplantation program:Lessons learned andfuture strategies显示文摘This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used. | Eugenia Pareja Ibars Miriam Cortes Laia Tolosa Maria JoséGómez-Lechón Slivia López JoséVicente Castell JoséMir | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 5 | Identification and proteolytic processing of procardosin A显示文摘 | Ramalho-Santos M Verissimo P Cortes L | 1998 | Eur J Biochem1998，255，1： | 1 |
| 6 | Flow cytometric analysis of spontaneous and dexamethasone-induced apoptosis in thymocytes from severely malnourished rats 显示文摘 | Ortiz R Cortes L Gonzalez-Marquez H | 2001 | Br J Nutr2001，86，5： | 1 |
| 7 | Key pa- rameter for tensile and compressive strength of fiber-re- inforced soil-lime mixtures 显示文摘 | CONSOLI N C CORTE M B FESTUGATO L | 2012 | Geosynthetics Interna- tional2012，19，5： | 1 |
| 8 | Efficacy of eribu-lin in women with metastatic breast cancer: a pooled analysis of two phase 3 studies显示文摘 | Twelves C Cortes J Vahdat L | 2014 | Breast Cancer Res Treat2014，148，3： | 1 |
| 9 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 10 | Vascular Complications After Orthotopic Liver Transplantation: Hepatic Artery Thrombosis显示文摘 | E. Pareja M. Cortes R. Navarro F. Sanjuan R. López J. Mir | 2010 | Transplantation Proceedings2010，，8： | 1 |
| 11 | Analysis of embedded CORBA middleware performance on urban dis- tributed transportation equipments 显示文摘 | TORAL S L BARRERO F CORTES F | 2013 | Computer Stand- ards & Interfaces2013，35，1： | 1 |
| 12 | pH- Dependent Gating in the Streptomyces lividans K^+ Channel显示文摘 | CUELLO L ROMERO J CORTES D | 1998 | Biochemistry1998，37，： | 1 |
| 13 | The decade 1989-1998 in Spanish psychology: An analysis of research in social psychology 显示文摘 | de la Corte L | 2001 | Span J Psychol2001，4，2： | 1 |
| 14 | Neurological involvement in North Italian patients with Behcet disease 显示文摘 | Lo Monaco A La Corte R Caniatti L | 2006 | Rheumatology Intenational2006，26，12： | 1 |
| 15 | The accuracy and precision of the experimental adetermination in the 1/E^1+α epithermal neutron spectrum显示文摘 | de CORTE F SORDO K MOENS L | 1981 | J Radioanal Chem1981，62，12： | 1 |
| 16 | Analysis of the indoor broadband power-Line noise scenario 显示文摘 | CORTES J A DIEZ L CANETE F J | 2010 | Electromagnetic Compatibility IEEE Transactions on2010，52，4： | 1 |
| 17 | Connective tissue growth factor and its -regulation: a new element in diabetic glomerulosclerosis显示文摘 | RISER B L CORTES P | 2001 | Renal Failure2001，23，： | 1 |
| 18 | Modification and generalization of some methods to improve the accuracy of α-determination in the 1/E^1+α epithermal neutron spectrum显示文摘 | de CORTE F MOENS L SORDO K | 1979 | J Radioanal Chem1979，52，2： | 1 |
| 19 | Parallel ordinary kriging interpolation incorporating automatic variogram fitting 显示文摘 | PESQUER L CORTES A PONS X | 2010 | Computers Geosciences2010，37，4： | 1 |
| 20 | Secondary voltage control: analysis, solutions and simulation results for the spanish transmission system显示文摘 | SANCHA J L FERNANDEZ J L CORTES A | 1996 | IEEE Trans on Power Systems1996，11，2： | 1 |
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