|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system显示文摘The liver functions,in part,to prevent exposure of the body to potentially harmful substances ingested in the diet.While it is highly efficient at accomplishing this,it is frequently prone to liver injury due to the biotransformation of xenobiotics into toxic metabolites.To counter this injury,the liver has evolved a unique capacity to rapidly and efficiently repair itself.Successful resolution of acute liver injury relies on hepatic macrophage populations that orchestrate the reparative response.After injury,Kupffer cells,the resident macrophages of the liver,become activated and secrete proinflammatory cytokines.These cytokines recruit other immune cells,including monocyte-derived macrophages,to the liver where they contribute to the repair process.Monocyte-derived macrophages traffic into the necrotic foci where they rapidly phagocytose dead cell debris.Simultaneous with this process,these cells change phenotype from a proinflammatory macrophage to a prorestorative macrophage that produce pro-mitogenic growth factors and antiinflammatory cytokines.Ultimately this process triggers resolution of inflammation,and along with proliferation of other hepatic cells,restores the liver architecture and function.While the mechanisms regulating specific macrophage functions during repair remain to be elucidated,recent studies indicate a key role for the fibrinolytic system in coordinating macrophage function during repair.In this review,we will highlight the function and role of hepatic macrophages in repair after acute liver injury,and will discuss the role of the fibrinolytic enzyme,plasmin,in regulation of these various processes. | Katherine Roth Jenna Strickland Bryan L Copple | 2020 | World Journal of Gastroenterology2020，26，16： | 3 |
| 2 | Extract of Ginkgo biloba induces phase 2 genes through Keapl-Nrf2-ARE signaling pathway显示文摘 | LIU XP GOLDRING CE COPPLE IM | 2007 | Life Sci2007，80，17： | 1 |
| 3 | Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicityimplications for therapeutic targeting of Nrf2显示文摘 | Olayanju A Copple IM Bryan HK Edge GT Sison RL Wong MW | 2015 | Free Radic Biol Med2015，78，： | 1 |
| 4 | Screening for IgG antinuclear autoantibodies by HEp-2 indirect fluores- cent antibody assays and the need for standardization显示文摘 | Copple SS Giles SR Jaskowski TD | 2012 | Am J Clin Pathol2012，137，5： | 1 |
| 5 | Quadratic system with a degenerate critical point显示文摘 | COPPLE W A | 1988 | Bull Austral Math Soc1988，38，： | 1 |
| 6 | Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure显示文摘 | COPPLE B L BANES A GANEY P E | 2002 | Toxicol Sci2002，65，2： | 1 |
| 7 | Screening for IgG antinuelear autoantibodies by HEp-2 indirect fluorescent antibody assays and the need for standardization 显示文摘 | Copple SS Giles SR Jaskowski TD | 2012 | American journal of clinical pathology2012，137，5： | 1 |
| 8 | Oxidative stress and the patho- genesis of eholestasis显示文摘 | Copple BL Jaeschke H Klaassen CD | 2010 | Semin Liver Dis2010，30，2： | 1 |
| 9 | The role of heme andthe mitochondrion in the chemical and molecular mechanisms ofmammalian cell death induced by the artemisinin antimalarials显示文摘 | Mercer A E Copple I M Maggs J L | 2011 | J Biol Chem2011，286，2： | 1 |
| 10 | Extract of Ginkgo biloba induces phase 2 genes through Keapl-Nrf2-ARE signaling pathway显示文摘 | LIU X P Goldring C E Copple I M | 2007 | Life Sci2007，80，17： | 1 |
| 11 | The role of heine and the mitochondrion in the chemical and molecular mecha- nisms of mammalian cell death induced by the artemisinin antimalarials 显示文摘 | Mercer A E Copple I M Maggs J L | 2011 | Journal of Biological Chemistry2011，286，2： | 1 |
| 12 | The hepatotoxie metabolite of acetaminophen directly activates the Keapl-Nrf2 cell defense system显示文摘 | Copple IM Goldring CE Jenkins RE | 2008 | Hepatology2008，48，4： | 1 |
| 13 | Physical and functional interaction of sequestosome 1 with Keapl regulates the Keapl-Nrf2 cell defense pathway显示文摘 | Copple I M Lister A Obeng A D Kitteringham N R Jenkins R E Layfield R Foster B J | | 0，，22： | 1 |
| 14 | Fostering young childrens representation, planning, and reflection: a focus in three current early childhoodmede]s 显示文摘 | Carol Copple | 2003 | Applied Developmental Psychology2003，，24： | 1 |
| 15 | The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials显示文摘 | Amy E. Mercer Ian M. Copple James L. Maggs B. Kevin Park | 2010 | Toxicology2010，，： | 1 |
| 16 | Bile Acids Induce Inflammatory Genes in Hepatocytes:A Novel Mechanism of Inflammation during Obstructive Cholestasis显示文摘 | Alien K Jaeschke H Copple BL | 2011 | Am J Pathol2011，178，1： | 1 |
| 17 | Dichotomous and reducibility显示文摘 | Coppl W A | | 0，，03： | 1 |
| 18 | Cell surface phenotyping and cytokine production of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs) 显示文摘 | wroblewski JM Copple A Batson LP | 2002 | Immunol Methods2002，264，12： | 1 |
| 19 | Hypoxia stimulates hepatocyte epitheli-al to mesenchymal transition by hypoxia-induciblefactor and transforming growth factor-beta-depend-ent mechanisms显示文摘 | Copple BL | 2010 | Liver Int2010，30，5： | 1 |
| 20 | The hepatotoxic metabolite of acetaminophen directly activates the Keapl-Nrf 2 cell defense system 显示文摘 | Copple IM Goldring CE Jenkins RE | 2008 | Hepatology2008，48，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员