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| 1 | Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer显示文摘Colorectal cancer(CRC)is one of the most common cancer worldwide and results from the accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to cell proliferation and metastasis.Unfortunately,CRC prognosis is still poor and the search of novel diagnostic and prognostic biomarkers is highly desired to prevent CRC-related deaths.The present article aims to summarize the most recent findings concerning the use of either genetic or epigenetic(mainly related to DNA methylation)biomarkers for CRC diagnosis,prognosis,and response to treatment.Recent large-scale DNA methylation studies suggest that CRC can be divided into several subtypes according to the frequency of DNA methylation and those of mutations in key CRC genes,and that this is reflected by different prognostic outcomes.Increasing evidence suggests that the analysis of DNA methylation in blood or fecal specimens could represent a valuable non-invasive diagnostic tool for CRC.Moreover,a broad spectrum of studies indicates that the inter-individual response to chemotherapeutic treatments depends on both epigenetic modifications and genetic mutations occurring in colorectal cancer cells,thereby opening the way for a personalized medicine.Overall,combining genetic and epigenetic data might represent the most promising tool for a proper diagnostic,prognostic and therapeutic approach. | Fabio Coppedè Angela Lopomo Roberto Spisni Lucia Migliore | 2014 | World Journal of Gastroenterology2014，20，4： | 29 |
| 2 | Genetics, Cytogenetics, and Epigenetics of Colorectal Cancer显示文摘 | Lucia Migliore Francesca Migheli Roberto Spisni Fabio Coppedè Nathan A. Ellis | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 2 |
| 3 | CO2加氢催化剂Cu/ZrO2/SiO2上Zr(IV)表面位对甲醇生成速率的影响(英文)显示文摘Cu/ZrO2/SiO2是有效的CO2选择加氢制甲醇催化剂.为了理解混合氧化物基催化剂中ZrO2的作用,在Cu和Zr的K边进行了原位X-射线吸收光谱测试.在反应条件下, Cu保持金属态,而Zr以三类配位环境的形式存在:体相ZrO2,配位饱和的、以及不饱和的Zr(Ⅳ)表面位.配位不饱和Zr表面位可通过线性拟合参比的X射线吸收近边结构光谱进行定量,发现其数量与甲醇生成速率有关,因而表明Zr(Ⅳ)Lewis酸表面位在驱动选择生成甲醇反应中的重要性.这与提出的机理是一致的:在裂解H2的Cu纳米颗粒与稳定反应中间体的Zr(Ⅳ)表面位之间的界面上进行CO2加氢. | Erwin Lam Kim Larmier Shohei Tada Patrick Wolf Olga V. Safonova Christophe Copéret | 2019 | Chinese Journal of Catalysis2019，40，11： | 2 |
| 4 | Age and race differences in racial stereotype awareness and endorsement显示文摘 | Kristine E. Copping Beth Kurtz‐Costes Stephanie J. Rowley Dana Wood | 2013 | J Appl Soc Psychol2013，，5： | 2 |
| 5 | Increase in visfatin after weight loss induced by gastroplastic surgery显示文摘 | Krzyzanowska K Mittermayer F Cop HP | 2006 | Obesity2006，14，： | 1 |
| 6 | Serum and peritoneal fluid immunological markers in adolescent girls with chronic pelvic pain显示文摘 | DROSDZOL - COP A SKRZYPULEC - PLINTA V STOJKO R | 2012 | Obstet Gynecol Surv2012，67，6： | 1 |
| 7 | The pseudo-Smarandache functions显示文摘 | COP SKI D | 2000 | Sma-randache Notions J2000，12，： | 1 |
| 8 | Environmental-induced oxidative stress in neurodegenerative disorders and aging显示文摘 | Migliore L Copped F | 2009 | Mutat Res2009，674，12： | 1 |
| 9 | Guidelines Group of the standards of Care Committee of the BTs,diagnosis and management of stable Cop D显示文摘 | The Cop D | 1997 | Thorax1997，52，： | 1 |
| 10 | Structural requirements for biological-activity of the marine alkaloid ascididemin显示文摘 | Lindsay B S Barrows L R Cop B R | 1995 | Bioorg Med Chem Lett1995，5，： | 1 |
| 11 | The concurrent accumulation of intraabdominal and subcutaneous fat ex plains the association between insulin resistance and plasma leptin concentrations:distinct metabolic effects of two fat compartments显示文摘 | Cop M Landchild MJ Vidal J | 2002 | Diabetes2002，51，： | 1 |
| 12 | Neonatal chylothorax : a etiology, clinical course and efficacy of Treatment显示文摘 | Cop'ons Fernandez C Benitez Segura I Castillo Salinas F | 2008 | An Pediatr ( Barc )2008，68，3： | 1 |
| 13 | Antiproliferative actions of the synthetic andorgen,miboleorne,in breast cancer ceils are mediated by both androgen and progesterone receptors 显示文摘 | Cops EJ Bianco-Miotto T Moore NL | 2008 | J Steroid Biochem Mol Biol2008，110，3： | 1 |
| 14 | Utilization of urea by the domestic rabbit: effect of age显示文摘 | COPPINGS R SHANHBEDIZADEH M ANDREWS G | 1988 | Journal of Applied Rabbit Research1988，11，： | 1 |
| 15 | Identifying patients at risk: ADA's definitions for nutrition screening and nutrition assessment 显示文摘 | Council on practice (COP) quality management committee | 1994 | J Am Diet Assoc1994，94，： | 1 |
| 16 | Characteristics of DSM-Ⅳ attention deficit hyperactivity disorder combined and predominantly inattentive subtypes in a Turkish clinical sample显示文摘 | Oner O Oner P Cop E | | 0，，04： | 1 |
| 17 | An Intuitionistic Fuzzy Weighted OWA Operator and Its Application 显示文摘 | Liang X Wei Cop Chen Zem | 2013 | Intemational Journal of Ma- chine Learning and Cybernetics2013，4，6： | 1 |
| 18 | Hu- man Centered Processes and Decision Support Sys- tems 显示文摘 | BARTHELEMY J P BISDOFF R COPPING | 2002 | European Journal of Operational Research2002，136，2： | 1 |
| 19 | Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective显示文摘Epigenetic mechanisms regulate the chromatin structure and gene expression levels without changing the primary DNA sequence,and include DNA methylation and hydroxymethylation,post-translational modifications of histone tails and nucleosome positioning,as well as mechanisms mediated by long and short non-coding RNA molecules.These mechanisms are required for human development and cell differentiation,and are pivotal in differentiated cells for cellular functions,allowing a tight regulation of gene expression levels in response to environmental stimuli and cellular metabolic demands(Coppedè,2021b).Particularly,the neuronal epigenome is highly sensitive to external stimuli and its function is required for learning and memory processes(Creighton et al.,2020).Several enzymes,collectively referred to as the“epigenetic machinery”,add,remove and read epigenetic marks,allowing chromatin remodeling to promote or repress gene transcription.The activity of these enzymes allows the reversibility of epigenetic marks,which is pivotal in neurons for memory formation and consolidation(Creighton et al.,2020). | Fabio Coppedè | 2022 | Neural Regeneration Research2022，17，8： | 1 |
| 20 | Sex differences in impulsivity:A meta-analysis显示文摘 | CROSS CP COPPING LT CAMPBELL A | 2011 | Psychol Bull2011，137，1： | 1 |
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