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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | PGE1 suppresses macrophage infiltration and ameliorates injury in an experimental model of macrophages in anti-glomerulonephritis显示文摘 | Cattell V Suith J Cook H T | 1990 | Clin Exp Immunol1990，79，： | 2 |
| 3 | Evaluation of a practice guideline for noninvasive positive pressure ventilation for acute respiratory failure显示文摘 | Sinuff T Cook Dj Randall J | 2003 | Chest2003，123，6： | 1 |
| 4 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 5 | Nature of the spermatogenic arrest in Dazl -/-mice显示文摘 | SCHRANS - STASSEN B H SAUNDERS P T COOKE H J | 2001 | Biol Re- prod2001，65，3： | 1 |
| 6 | Archive,records,and power:the making of modern memory显示文摘 | Schwartz J M Cook T | 2002 | Archival Science2002，2，12： | 1 |
| 7 | From rural single- county to muhicounty regional transit systems: Benefits of consolidation显示文摘 | Cook T J J J Lawrie A J Henry | 2003 | Transportation Research Record2003，，1841： | 1 |
| 8 | A methodology for the as- sessment of unconventional(continuous) resources with an ap- plication to the Greater Natural Buttes Gas Field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | Natural Resources Research2010，19，4： | 1 |
| 9 | Tetanus显示文摘 | Farrar J J Yen L M Cook T | 2000 | J Neurol Neurosurg Psychiatry2000，69，： | 1 |
| 10 | The gamblers fallacy in lottery play 显示文摘 | CLOTFELTER C T COOK P J | 1993 | Manag Sci1993，39，12： | 1 |
| 11 | The ProSeal laryngeal mask airway: a review of the literature显示文摘 | COOK T M LEE G NOLAN J P | 2005 | Can J Anaesth2005，52，7： | 1 |
| 12 | Histopathology atlas of animal model systems - overview of guiding principles 显示文摘 | Aigner T Cook J L Gerwin N | 2010 | Osteoarthritis Cartilage2010，18，10： | 1 |
| 13 | Ethanol causes accelerated GI arrest in differentiating HL260 cells显示文摘 | COOK R T KEINER J A YEN A | 1990 | Alc Clin Exp Res1990，14，： | 1 |
| 14 | Evaluation of a practice guideline for noninvasive positive pressure ventilation for acute respiratory failure显示文摘 | Sinuf T Cook DJ Randall J | 2003 | Chest2003，123，： | 1 |
| 15 | Histamine receptors on submucous neurons in guinea pig colon显示文摘 | Frieling T Cooke I/J Wood JD | 1993 | Am J Physiol1993，264，11： | 1 |
| 16 | Minerals of the system Bi-Te-Se-S related to the tetradymite archetype: Review of classification and compositional variation显示文摘 | COOK N J CIOBANU C L WAGNER T | 2007 | The Canadian Mineralogist2007，45，4： | 1 |
| 17 | The long term proghostic significance of oestrogen receptor analysis in early carcinoma of the breast显示文摘 | Winstanley J Cooke T George W D | 1991 | Br J Cancer1991，64，1： | 1 |
| 18 | Chromosome 17aneu- somy is associated with poor prognostic factors in invasive breast carcinomal 显示文摘 | Watters A D Going J J Cooke T G | 2003 | Breast Cancer Res Treat2003，77，2： | 1 |
| 19 | Envelope determinants of equine infectious anemia virus vaccine protection and the effects of sequence variation on immune recognition显示文摘 | Tagmyer T L Craigo J K Cook S J | 2008 | J Virol2008，82，8： | 1 |
| 20 | Sp1- and Kruppel-like transcription factors显示文摘 | Kaczynski J Cook T Urrutia R | 2003 | Genome Biol2003，4，2： | 1 |
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