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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 3 | Infection and autoimmunity:are we winning the war,only to lose the peace?显示文摘 | Cooke A Zaccone P Raine T | 2004 | Trends Parasitol2004，20，7： | 1 |
| 4 | From rural single- county to muhicounty regional transit systems: Benefits of consolidation显示文摘 | Cook T J J J Lawrie A J Henry | 2003 | Transportation Research Record2003，，1841： | 1 |
| 5 | A methodology for the as- sessment of unconventional(continuous) resources with an ap- plication to the Greater Natural Buttes Gas Field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | Natural Resources Research2010，19，4： | 1 |
| 6 | Ethanol causes accelerated GI arrest in differentiating HL260 cells显示文摘 | COOK R T KEINER J A YEN A | 1990 | Alc Clin Exp Res1990，14，： | 1 |
| 7 | Bonded stress model for design of adhesive anchors 显示文摘 | Cook R A Dpeer G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
| 8 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 9 | Chromosome 17aneu- somy is associated with poor prognostic factors in invasive breast carcinomal 显示文摘 | Watters A D Going J J Cooke T G | 2003 | Breast Cancer Res Treat2003，77，2： | 1 |
| 10 | Effect of clot removal on cerebrovascular contraction after subarachnoid hemorrhage in the monkey: pharmacological study显示文摘 | TSUJI T COOK D A | 1996 | Heart Vessels1996，11，2： | 1 |
| 11 | A methodology for theassessment of unconventional(continuous) resources with anapplication to the greater natural Buttes gas field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | NaturalResources Research2010，19，4： | 1 |
| 12 | Evidence of compositional differences between the extracellular and intracellular DNA of a granular sludge biofilm 显示文摘 | Cheng M Cook A E Fukushima T | 2011 | Appl Microbiol Lett2011，53，： | 1 |
| 13 | The mechanisms of the formation and growth of water bubbles and associated dislocation loops in synthetic quartz显示文摘 | McLaren A C Cook R F Hyde S T | 1983 | Phys Chem Mineral1983，9，： | 1 |
| 14 | Creating open government ecosystems: A research and development agenda 显示文摘 | Harrison T M Pardo T A Cook M | 2012 | Future Internet2012，4，4： | 1 |
| 15 | Hydrocarbon potential of the Barnett Shale (Mississippian) Delaware Basin, West Texas and Southeastem New Mexico 显示文摘 | Kinley T J Cook L W Breyer J A | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 16 | Mimosine arrests the cell cycle after cells enter S-phase显示文摘 | Hughes T A Cook P R | 1996 | Exp Cell Res1996，222，2： | 1 |
| 17 | Removal of oil,grease,and suspended solids from produced water with ceramic crossflow microfiltration显示文摘 | Chen A S C Flynn J T Cook R G | 1991 | SPE Production Engineering1991，6，2： | 1 |
| 18 | Rates of stone loss at St Paul' s Cathedral, London 显示文摘 | Trudgill S T Viles H A Cooke R U | 1990 | Atmospheric Enviroltment ( Part B)1990，24，2： | 1 |
| 19 | Bond stress model for design of adhesive anchors显示文摘 | Cook R A Doerr G T Klingner R E | 1993 | ACI Structural Journal1993，90，5： | 1 |
| 20 | Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat显示文摘 | Fungwe T V Cagen L M Cook G A | | 0，，： | 1 |
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