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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 3 | Strain Induced Martensite Formation in StainlessSteel 显示文摘 | Cook D C | 1978 | Metall Trans A1978，18，2： | 2 |
| 4 | Anticancer activity of a new compound from Camptotheca acuminata显示文摘 | WALL M E WANI M C COOK C E | 1966 | J Am Chem Soc1966，88，： | 1 |
| 5 | Examination of the melatonin hypothesis in women exposed at night to EMF or bright light显示文摘 | GRAHAM C COOK M R GERKOVICH M M | 2001 | Environ Health Perspect2001，109，5： | 1 |
| 6 | Stem cells and renal regeneration 显示文摘 | Roufosse C Cook HT | 2008 | Nephron ExpNephrol2008，109，2： | 1 |
| 7 | Multiple organ dysfunction score:a reliable description of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 8 | A study of 4-substituted 5,5-diaryl oxazolidin-2-ones as efficacious chiral auxiliaries显示文摘 | Gibson C L Gillon K Cook S | 1998 | Tetrahedron Lett1998，39，： | 1 |
| 9 | Smalll-intestinal coccidiosis:an emergent clinicalproblem显示文摘 | COOK G C | 1988 | J Infect1988，16，： | 1 |
| 10 | Immune modulation by altered nutrient metabolism:nutritional control of immune-induced growth depression显示文摘 | Cook M E Miller C C Park Y | 1993 | Poult-Sci1993，72，： | 1 |
| 11 | Arthroscopic verification of ultrasonographic diagnosis of meniscal pathology in dogs显示文摘 | Mahn M M Cook J L Cook C R | 2005 | Vet Surg2005，34，4： | 1 |
| 12 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 13 | National Ignition Facility target design and fabrication显示文摘 | COOK R C KOZIOZIEMSKI B J NIKROO A | 2008 | Laser and Particle Beams2008，26，3： | 1 |
| 14 | Spectral beam combining of Yb-doped fiber lasers in an external cavity 显示文摘 | Cook C C Fan T Y Fejermm | 1999 | OSA Trends in Optics and Photonics1999，26，： | 1 |
| 15 | Analysis of compressive fracture in rock using statistical techniques : Part II : effect of mi- croscale heterogeneity on macroscopic deformation 显示文摘 | Blair S C Cook N G | 1998 | International Journal of Rock Mechanics and Mining Sciences 8< Geomechanics Abstracts1998，35，7： | 1 |
| 16 | Reliability and validity of servqual scores used to evaluate perceptions of li- brary service quality显示文摘 | Cook C Thompson B | 2000 | Journal of Academic Librari- anship2000，，26： | 1 |
| 17 | Cyber bullying behaviors a-mong middle and high school students显示文摘 | MISHNA F COOK C GADALLA T | 2010 | Am J Orthopsychiatry2010，80，3： | 1 |
| 18 | Results of the pilot studyfor the Hypertension in the Very Elderly Trial显示文摘 | Bulpitt C J Beckett N S Cooke J | 2003 | J Hypertens2003，21，12： | 1 |
| 19 | Systematic reviews: synthesis of best evidence for clinical decisions 显示文摘 | COOK D J MULROW C D HAYNES R B | 1997 | Aim Intern Med1997，126，5： | 1 |
| 20 | Fractionation of polyethylene显示文摘 | FRSNCIS P S COOKE R C Jr ELLIOTT J H | 1958 | J Polym Sci1958，31，123： | 1 |
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