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| 1 | Major osteoporotic fragility fractures: Risk factor updates and societal impact显示文摘Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders(for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence. | Paola Pisani Maria Daniela Renna Francesco Conversano Ernesto Casciaro Marco Di Paola Eugenio Quarta Maurizio Muratore Sergio Casciaro | 2016 | World Journal of Orthopedics2016，7，3： | 39 |
| 2 | Sonographic markers for early diagnosis of fetal malformations显示文摘Fetal malformations are very frequent in industrialized countries.Although advanced maternal age may affect pregnancy outcome adversely,80%-90%of fetal malformations occur in the absence of a specific risk factor for parents.The only effective approach for prenatal screening is currently represented by an ultrasound scan.However,ultrasound methods present two important limitations:the substantial absence of quantitative parameters and the dependence on the sonographer experience.In recent years,together with the improvement in transducer technology,quantitative and objective sonographic markers highly predictive of fetal malformations have been developed.These markers can be detected at early gestation(11-14 wk)and generally are not pathological in themselves but have an increased incidence in abnormal fetuses.Thus,prenatal ultrasonography during the second trimester of gestation provides a'genetic sonogram',including,for instance,nuchal translucency,short humeral length,echogenic bowel,echogenic intracardiac focus and choroid plexus cyst,that is used to identify morphological features of fetal Down’s syndrome with a potential sensitivity of more than 90%.Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal anomalies.In the future,sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis(amniocentesis,etc.). | Maria Daniela Renna Paola Pisani Francesco Conversano Emanuele Perrone Ernesto Casciaro Gian Carlo Di Renzo Marco Di Paola Antonio Perrone Sergio Casciaro | 2013 | World Journal of Radiology2013，5，10： | 12 |
| 3 | 屏蔽并且通过 X 光检查和超声的骨质疏松症的早诊断基于技术显示文摘 Effective prevention and management of osteoporosis would require suitable methods for population screenings and early diagnosis. Current clinicallyavailable diagnostic methods are mainly based on the use of either X-rays or ultrasound(US). All X-ray based methods provide a measure of bone mineral density(BMD), but it has been demonstrated that other structural aspects of the bone are important in determining fracture risk, such as mechanical features and elastic properties, which cannot be assessed using densitometric techniques. Among the most commonly used techniques, dual X-ray absorptiometry(DXA) is considered the current 'gold standard' for osteoporosis diagnosis and fracture risk prediction. Unfortunately, as other X-ray based techniques, DXA has specific limitations(e.g., use of ionizing radiation, large size of the equipment, high costs, limited availability) that hinder its application for population screenings and primary care diagnosis. This has resulted in an increasing interest in developing reliable pre-screening tools for osteoporosis such as quantitative ultrasound(QUS) scanners, which do not involve ionizing radiation exposure and represent a cheaper solution exploiting portable and widely available devices. Furthermore, the usefulness of QUS techniques in fracture risk prediction has been proven and, with the last developments, they are also becoming a more and more reliable approach for assessing bone quality. However, the US assessment of osteoporosis is currently used only as a pre-screening tool, requiring a subsequent diagnosis confirmation by means of a DXA evaluation. Here we illustrate the state of art in the early diagnosis of this 'silent disease' and show up recent advances for its prevention and improved management through early diagnosis. | Paola Pisani Maria Daniela Renna Francesco Conversano Ernesto Casciaro Maurizio Muratore Eugenio Quarta Marco Di Paola Sergio Casciaro | 2013 | World Journal of Radiology2013，5，11： | 4 |
| 4 | Effects of summer ice coverage on phytoplankton assemblages in the Ross Sea,Antarctica显示文摘 | Mangoni O Modigh M Conversano F | | 0，，： | 1 |
| 5 | Headspace solid- phase microextraction-gas chromatography-mass spectrometry for profiling free volatile compounds in Cabernet Sauvignon grapes and wines显示文摘 | Canuti V Conversano M Calzi M L | 2009 | Journal of Chromatography A2009，1216，15： | 1 |
| 6 | Interferon o therapy in patients with chronic hepatitis C infection: Quality of life and depression显示文摘 | Conversano C Carmassi C Carlini M | 2015 | Hematol Rep2015，7，1： | 1 |
| 7 | Afla- toxins in aquatic species: metabolism, toxicity and perspec- tives 显示文摘 | Santacroce M P Conversano M C Casalino E | 2008 | Reviews in Fish Biology and Fisheries2008，18，： | 1 |
| 8 | Multiparametric evaluation of the acoustic behavior of halloysite nanotubes for medical echographic image enhancement显示文摘 | Soloperto G Conversano F Greco A | 2014 | IEEE Trans Instrumentation and Measurement2014，63，6： | 1 |
| 9 | Duplex polymerase chain reaction for detection of pork meat in horse meat fresh sausages from Italian retail sources显示文摘 | Pinto A D Forte V T Conversano M C | 2005 | Food Control2005，16，： | 1 |
| 10 | Neurode- velopmental outcome at 12 and 18 months in late preterm in- fants 显示文摘 | Romeo DM Di Stefano A Conversano M | 2010 | EurJ Paediatr Neurol2010，14，： | 1 |
| 11 | 水生物种中黄曲霉毒素的代谢及毒性研究(五)显示文摘3.7遗传毒性
国际癌症研究所(IARC)认定黄曲霉毒素是已知的最强基因毒性剂(IARC,1993)。在哺乳动物中,AFB,加合到DNA上后,可产生染色体畸变、微核、姐妹染色单体互换、程序外DNA合成及染色体链断裂(IARC,1993)。 | 王银东 黄广明 Santacroce M P Conversano M C Casalino E | 2010 | 中国畜牧杂志2010，46，16： | 1 |
| 12 | Af- latoxins in aquatic species: metabolism, toxicity and per- spectives 显示文摘 | Santacroce M P Conversano M C Casalino E | 2008 | Rev Fish Biol Fisher2008，18，： | 1 |
| 13 | Water mass properties and chemical signatures in the central Mediterranean region显示文摘 | Astraldi M Conversano F Civitarese G | 2002 | Journal of Marine Systems2002，3334，2002： | 1 |
| 14 | Ad- vanced spectral analyses for real-time automatic echographic tissue-typing of simulated tumor masses at different compres- sion stages显示文摘 | SOLOPERTO G CONVERSANO F GRECO A | 2012 | IEEE Trans Ultrason Ferroelectr Freq Con- trol2012，59，12： | 1 |
| 15 | Aflatoxins in aquatic species:metabolism,toxicity and perspectives 显示文摘 | Santacroce M P Conversano M C Casalino E | 2008 | Reviews in Fish Biology Fisheries2008，18，1： | 1 |
| 16 | New per- spectives in echographie diagnosis of osteoporosis on hip and spine 显示文摘 | Casciaro S Conversano F Pisani P | 2015 | Clin Cases Miner Bone Metab2015，12，： | 1 |
| 17 | Optimism and its impact on mental and physical well-being显示文摘 | Conversano C Rotondo A Lensi E | 2010 | Clin Prac Epidemiol Mental Health: CP & EMH2010，6，： | 1 |
| 18 | Neurodevelopmental outcome at 12 and 18 months in late preterm infants显示文摘 | Romeo DM Di Stefano A Conversano M | 2010 | Eur J Paediatr Neurol2010，14，6： | 1 |
| 19 | Optimism and its impact on mental and physical well-being显示文摘 | Conversano C Rotondo A Lensi E | 2010 | Clin Pract Epidemiol Ment Health2010，6，： | 1 |
| 20 | Aflatoxins in aquatic species: metabolism, toxicity and perspectives 显示文摘 | Santacroce M P Conversano M Casalino E | 2008 | Reviews in Fish Biology and Fisheries2008，18，： | 1 |
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