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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic显示文摘AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil.METHODS:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer.Clinical data and pathology features of the tumor were obtained from chart review.RESULTS:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC.Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,respectively.Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001).Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment.CONCLUSION:A significant proportion of patients with CRC were at high risk for LS.Education and training of health care professionals are essential to ensure proper management. | Patrícia Koehler-Santos Patricia Izetti Jamile Abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta Daniel C Damin Paulo Carvalho Contu Mario Antonello Rosito Patricia Ashton-Prolla Joāo Carlos Prolla | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 3 | HLA-Cw ARMS-PCR typing in the Sardinian population显示文摘 | Contu L Arras M Carcassi C | 1996 | Hum Immunol1996，49，1： | 1 |
| 4 | HLA-B35 frequency variations correlate with malaria infection in Serdinia显示文摘 | Carcaasi C Orru S | 1998 | Tissue Antigens1998，52，5： | 1 |
| 5 | HLA-Cw ARMS-PCR typing in the Sardinian population 显示文摘 | Flons L Carcassia C | 1996 | Human Immunology1996，49，： | 1 |
| 6 | First trimester diagnosis ofsirenomelia by 2D and 3D ultrasound显示文摘 | Contu R Zoppi MA Axiana C | | 0，，01： | 1 |
| 7 | First Trimester Diag- nosis of Sirenomelia by 2D and 3D Ultrasound 显示文摘 | Contu R Zoppi MA Axiana C | 2009 | Fetal Diagn Ther2009，26，1： | 1 |
| 8 | Moss(Bryum radiculosum) as a bioindicator of trace metal deposition around an industrialized area in Sardinia (Italy)显示文摘 | Schintu M Cogoni A Durante L Cantaluppi C Contu A | 2005 | Chemo-sphere2005，60，： | 1 |
| 9 | Fibrin glue in the management of complex anal fistula显示文摘 | Damin D C Rosito M A Contu P C | 2009 | Arq Gastroenterol2009，46，4： | 1 |
| 10 | First trimester diagnosis of sirenomelia by 2D and 3D ultrasound显示文摘 | Contu R Zoppi MA Axiana C | 2009 | Fetal Diagn Ther2009，26，： | 1 |
| 11 | Exogenous and endogenous glycolipid antigen activate NKT cells during microbial infections显示文摘 | Mattren J Debord K Ismail N Goff R Contu C Zhou D Saint Mezard P Wang V Gao Y Yin N Hoeba K Schneewind O Walker D | 2005 | Nature2005，434，7032： | 1 |
| 12 | Lack of correlation between p53 codon 72 polymorphism and anal cancer risk显示文摘AIM:To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS:Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study.p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS:The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION:These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis. | Simone S Contu Grasiela Agnes Andrea P Damin Paulo C Contu Mário A Rosito Claudio O Alexandre Daniel C Damin | 2009 | World Journal of Gastroenterology2009，15，36： | 0 |
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