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| 1 | Smad3 knock-out mice as a useful model to study intestinal fibrogenesis显示文摘瞄准:为了在形态学和免疫评估可能的差别, CD3,转变生长因素 beta1 (TGF-beta1 ) , Smad7, alpha 光滑的肌肉肌动朊(alpha-Sma ) ,和骨胶原的组织化学的表示打 I-VII 小并且在 Smad3 空、野类型的老鼠的大肠。方法:十 0 和十只野类型的成年老鼠在年龄和机关的 4 瞬间被牺牲(食管,小、大的肠,输尿管) 为组织学被收集(苏木精和曙红,马森 thrichrome,染色的银) ,形态测定法和免疫组织化学分析。肠的织物 homogenates 的 TGF-beta1 层次被 ELISA 估计。结果:没有宏观的肠的损害在空、野类型的老鼠两个都被检测。组织学并且 morphometric 评估在肌肉层厚度揭示了重要减小小并且在空老鼠的大肠同样与野类型的老鼠相比。Immunohistochemistry 评估显示出染色在的 CD3+ T 房间, TGF-beta1 和 Smad7 的重要增加小并且 Smad3 空老鼠的大肠粘膜同样与野类型的老鼠相比。染色的 Alpha-Sma 和骨胶原 I-VII 小并且大肠没在二组老鼠之间不同。结肠的织物 homogenates 的 TGF-beta1 层次比在野类型的老鼠在空老鼠是显著地更高的。在初步的实验,导致 TNBS 的肠的纤维变性的重要减小作为与野类型的老鼠相比在空老鼠被观察。结论:Smad3 空老鼠是一个有用模型调查在肠的发炎和纤维变性表明小径的 TGF-beta/Smad 的在活体内角色。 | Giuliana Zanninelli Antonella Vetuschi Roberta Sferra Angela D'Angelo Amato Fratticci Maria Adelaide Continenza Maria Chiaramonte Eugenio Gaudio Renzo Caprilli Giovanni Latella | 2006 | World Journal of Gastroenterology2006，12，8： | 3 |
| 2 | Effects of estradiol on in vitro cultures of human fibroblasts显示文摘 | CARTA G CONTINENZA MA RICCIARDI G | 1992 | Minerva Ginecol1992，44，12： | 1 |
| 3 | Electronicstructure of divalent hexaborides 显示文摘 | Massidda S Continenza A De Pascale T | 1996 | Zeitschrift Physik BCondensed Matter1996，102，： | 1 |
| 4 | Role of structural defects on the half-metallic character of heusler alloys and their junctions with Ge and GaAs 显示文摘 | Picozzi S Continenza A Freeman A J | 2005 | Leet Notes Phys2005，676，： | 1 |
| 5 | Role of Structural Defects on the Half-Metallic Character of Co2MnGe and Co2MnSi Heusler Alloys 显示文摘 | Picozzi S Continenza A | 2004 | Phys Rev B2004，69，： | 1 |
| 6 | Energetic Stability and Magnetic Properties of Mn Dimers in Silicon 显示文摘 | Bernardini F Picozzi S Continenza A | 2004 | Appl Phys Lett2004，83，： | 1 |
| 7 | Co2MnX (X: Si, Ge, Sn) Heusler compounds: An ab initio study of their structural, electronic, and magnetic properties at zero and elevated pressure显示文摘 | Picozzi S Continenza A Freeman A J | 2002 | Phys Rev B2002，66，09： | 1 |
| 8 | 查看详情显示文摘 | Picozzi S Continenza A Freeman A | | 0，，09： | 1 |
| 9 | Electronic struc- ture and ferromagnetism of Mn-doped group-IV semiconduc- tors 显示文摘 | Stroppa A Picozzi S Continenza A | 2003 | Phys Rev B2003，68，15： | 1 |
| 10 | Transition metal doping and clustering in Ge 显示文摘 | Continenza A Profeta G Picozzi S | 2006 | Appl Phys Lett2006，89，20： | 1 |
| 11 | In fiuence of growth direction and strain conditions on the band lineup at GaSb/InSb and InAs/ InSb interfaces显示文摘 | Picozzi S Continenza A | 1996 | Physical Review B1996，53，10： | 1 |
| 12 | Co2MnX(X=Si,Ge,Sn) Heusler Compounds:An ab Initio Study of Their Structural,Electronic,and Magnetic Properties at Zero and Elevated Pressure显示文摘 | Picozzi S Continenza A | 2002 | Phys Rev B2002，66，09： | 1 |
| 13 | Transition metal doping in Ge显示文摘 | Continenza A Profeta G Picozzi S | 2007 | Journal of Magnetism and Magnetic Materials2007，310，： | 1 |
| 14 | Role of structural defects on the half-metallic character of Co2MnGe and Co2MnSi Heusler alloys显示文摘 | Picozzi S Continenza A Freeman A J | 2004 | Phys Rev B2004，69，09： | 1 |
| 15 | Co2MnX(X = Si, Ge, Sn) Heusler compounds: An ab initio study of their structural, electronic, and magnetic properties at zero and ele- vated pressure显示文摘 | PICOZZI S CONTINENZA A FREEMAN A J | 2002 | Physical Review B2002，66，09： | 1 |
| 16 | Role of structural defects on the half-metallic character of Co2MnGe and Co2MnSi Heusler alloys 显示文摘 | Picozzi S Continenza A Freeman A J | 2004 | Phys Rev B2004，69，09： | 1 |
| 17 | Role of Structural Defects on the Half-metallic Character of Co2MnGe and Co2MnSi Heusler Alloys显示文摘 | Picozzi S Continenza A Freeman A J | 2004 | Phys Rev B2004，69，09： | 1 |
| 18 | Volume dependence of Anderson hybridization in cubic CeCd and CeAg显示文摘 | MONACHESI P ANDREANI L C CONTINENZA A MCMAHAN A K | | 0，，： | 1 |
| 19 | Co2MnX(X= Si, Ge, Sn) Heusler compounds: ab initio study of their structural, electronic, and magnetic properties at zero and elevated pressure显示文摘 | Picozzi S Continenza A Freeman A J | 2002 | Phys Rev B2002，66，09： | 1 |
| 20 | Electronic and magnetic properties of the spinel semiconductor CdCr2Se4显示文摘 | Continenza A Pascale T Meloni F | 1994 | Physical Review B1994，49，： | 1 |
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