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| 1 | Effectiveness of very low-volume preparation for colonoscopy:A prospective, multicenter observational study显示文摘BACKGROUND The effectiveness of colonoscopy strictly depends on adequate bowel cleansing.Recently,a 1 L polyethylene glycol plus ascorbate(PEG-ASC)solution(Plenvu;Norgine,Harefield,United Kingdom)has been introduced on the evidence of three phase-3 randomized controlled trials,but it had never been tested in the real-life.AIM To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L-PEG solutions in a real-life setting.METHODS All patients undergoing a screening or diagnostic colonoscopy after a 4,2 or 1 L PEG preparation,were consecutively enrolled in 5 Italian centers from September 2018 to February 2019.The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon.The secondary endpoints were the evaluation of tolerability,adherence and safety of the different bowel preparations.Bowel cleansing was assessed through the Boston Bowel Preparation Scale.Adherence was defined as consumption of at least 75%of each dose,while tolerability was evaluated through a semiquantitative scale.Safety was systematically monitored through adverse events reporting.RESULTS Overall,1289 met the inclusion criteria and were enrolled in the study.Of these,490 patients performed a 4 L-PEG preparation(Selgesse^■),566 a 2 L-PEG cleansing(Moviprep^■or Clensia^■)and 233 a 1 L-PEG preparation(Plenvu^■).Bowel cleansing by Boston Bowel Preparation Scale was 6.5±1.5 overall and 6.3±1.5,6.2±1.5,7.3±1.5(P<0.001)in the subgroups of 4 L,2 L and 1 L-PEG preparation,respectively.Cleansing success was achieved in 72.4%,74.1%and 90.1%(P<0.001),while a high-quality cleansing of the right colon in 15.9%,12.0%and 41.4%(P<0.001)for 4 L,2 L and 1 L-PEG preparation groups,respectively.The 1 L preparation was the most tolerated compared to the 2 and 4 L-PEG solutions in the absence of serious adverse events within any of the three groups.Multiple regression models confirmed 1 L PEG-ASC preparation as an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability.CONCLUSION This study supports the effectiveness and tolerability of 1 L PEG-ASC,also showing it is an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability. | Marcello Maida Emanuele Sinagra Gaetano Cristian Morreale Sandro Sferrazza Giuseppe Scalisi Dario Schillaci Marco Ventimiglia Fabio Salvatore Macaluso Giovanni Vettori Giuseppe Conoscenti Concetta Di Bartolo Serena Garufi Domenico Catarella Michele Manganaro Clara Maria Virgilio Salvatore Camilleri | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 2 | GIS analysis to assess landslide susceptibility in a fluvial basin of Nw Sicily(Italy)显示文摘 | Conoscenti C Di Maggio C Rotigliano E | 2008 | Geomorphology Geomorphology2008，94，34： | 1 |
| 3 | GIS analysis to assess landslide susceptibility in a fluvial basin of NW Sicily (Italy)显示文摘 | Conoscenti C DI Maggio C Rotiglinao E | | 0，，3： | 1 |
| 4 | GIS analysis to assess landslide susceptibility in a fluvial basin of NW Sicily (Italy)显示文摘 | Conoscenti C Maggio C D Rotigliano E | 2008 | Geomorphology2008，94，34： | 1 |
| 5 | Noninvasive face mask ventilation in patients with acute respiratory failure显示文摘 | Meduri GU Conoscenti CC Menashe P | 1989 | Chest1989，95，4： | 1 |
| 6 | The psychometric properties of the St George's Respiratory Questionnaire(SGRQ)in patients with idiopathic pulmonary fibrosis:a literature review显示文摘 | Swigris J J Esser D Conoscenti C S | 2014 | Health Qual Life Outcomes2014，12，1： | 1 |
| 7 | Lung function improvements with once--daily tiotropium in chronic obstructive pulmonary disease显示文摘 | Casaburi R Conoscenti CS | 2004 | Am J Med2004，117，12： | 1 |
| 8 | Noninvasive facemask ventilation in patients with acute respiratory faiIure 显示文摘 | Meduri GU Conoscenti CC Menashe P | 1989 | Chest1989，95，9： | 1 |
| 9 | Endometrial assessment by transvaginal sonography and histological findings after D&C in women with postmenopausal bleeding显示文摘 | Meyr Y Fischer Tamaro L | 1995 | Ultrasound Obstet Gynecol1995，6，1： | 1 |
| 10 | Noninvasive face mask ventilation in patients with acute respiratory failure显示文摘 | Meduri GU Conoscenti CC Menashe P et a1 | | 0，，04： | 1 |
| 11 | Does cervical length at 13-15 weeks'gestation predict pretem delivery in an unselected population显示文摘 | Conoscenti G Meir YJ D Ottavio G | 2003 | Ultrasound Obstet Gynecol2003，21，： | 1 |
| 12 | Prenatal diagnosis of di- lated coronary sinus with persistent left superior vena cava in a fetus with trisomy 18 显示文摘 | Kalache KD Romero R Conoscenti G | 2003 | Prenatal Diagnosis2003，23，2： | 1 |
| 13 | Noninvasive face mask ventilation in patients with acute respiratory ventilation 显示文摘 | Meduri GU Conoscenti CC Menashe P | 1989 | Chest1989，95，： | 1 |
| 14 | Noninvasive face mask ventilation in patients with acute respiratory failure显示文摘 | Meduri GU Conoscenti CC Menashe P | 1989 | Chest1989，95，4： | 1 |
| 15 | Gully erosion susceptibility assessment by means of GIS-based logistic regression: A case of Sicily (Italy)显示文摘 | Conoscenti C Angileri S Cappadonia C | 2014 | Geomorphology2014，204，： | 1 |
| 16 | Noninvasive face mask ventilation in patients with acute respiratory failure 显示文摘 | Meduri GU Conoscenti CC Menashe P | 1989 | Chest1989，95，4： | 1 |
| 17 | Noninvasive face mask ventilation in patients with acute respiratory ventilation 显示文摘 | Meduri GU ConoscentI CC Menashe P | 1989 | Chest1989，95，： | 1 |
| 18 | A multidisciplinary approach to the evaluation of the mechanism that triggered the Cerda landslide显示文摘 | Agnesi V Camarda M Conoscenti C | 2005 | Geomorphology2005，65，12： | 1 |
| 19 | Noninvasive face mask ventilation in patients with acute respiratory failure 显示文摘 | Medufi GU Conoscenti CC Menashe P | 1989 | Chest1989，95，4： | 1 |
| 20 | Lung function improvements with once-daily tiotropium in chronic obstructive pulmonary disease显示文摘 | Richard Casaburi Craig S. Conoscenti | 2004 | American Journal of Medicine Supplements2004，，12： | 1 |
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