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| 1 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 2 | Source-sink System and Sedimentary Model of Progradational Fan Delta Controlled by Restricted Ancient Gully:An Example in the Enping Formation in the Southern Baiyun Sag,Pearl River Mouth Basin,Northern South China Sea显示文摘Tectonic activity occurred during the depositional period of the Enping Formation in the southern Baiyun Sag in the Pearl River Mouth Basin,with a series of synsedimentary faults and a set of large fan delta reservoir bodies developing.There is no data from drilling,cores,etc.for this area,so this paper applies three-dimensional seismic data to study the structural style of the steep slope zone,the seismic facies characteristics of fan deltas,and the source-sink system and sedimentary model of the Enping Formation.The control action of tectonic activity on fan deltaic sedimentary systems is studied by combining interpretation of fault systems,dissection of structural styles,seismic reflection structure,seismic facies geometry,and seismic attribute analysis,together with theoretical analysis of the source-sink deposition process.The Baiyun Sag has experienced tectonic activity since the Eocene,and a series of synsedimentary faults are developed in the southern steep slope zone.Under the common control of multiple large synsedimentary faults,a large ancient gully formed in the steep slope zone in the south,which gradually widened from south to north.The uplift area in the southern part of the sag was exposed for a long time during the deposition of the Enping Formation and consequently suffered weathering and erosion.The resulting sediments were transported through a system of provenance channels composed of slopes and an ancient gully to the depression area,where they were deposited and eventually converged to form a large fan delta.The fan delta presents the overall characteristics of NS strong wedge reflection and EW strong domal reflection—thick in the middle part and thin in the wings.It displays a lobe-shaped distribution on the plane,with the fan root pointing to the south slope.According to differences in reflection intensity from bottom to top,it can be subdivided into three stages of progradational sedimentary bodies—the southern uplift and denudation zone,the large ancient gully,and the fan delta—which together constitute a complete source-sink system.This represents a sedimentary model of progradational fan delta under the overall joint control of the re stricted ancient gully and syndepositional faults. | FENG Congjun YAO Xingzong YANG Haizhang LI Daming SUN Mengsi | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 4 |
| 3 | Complex object 3D measurement based on phase-shifting and a neural network 显示文摘 | Li Zhongwei Shi Yusheng Wang Congjun | 2009 | Optics Communications2009，282，14： | 1 |
| 4 | Prediction of a low tight sandstone reservoir in the Majing gas field, Sichuan basin,China显示文摘 | Li Congjun Zhang Xiaopeng Zhang Shaonan | 2004 | Journal of Geophysics and Engineering2004，，3： | 1 |
| 5 | Current status of greenhouse gas emissions from aquaculture in China显示文摘Aquaculture and mariculture are becoming an increasingly important source of food supply in many countries and regions.However,with the expansion of aquaculture and mariculture comes increasing emissions of greenhouse gases(GHG)which contribute to global warming and climate change.China leads the world in aquaculture and mariculture production,but there are no studies that systematically assess China's overall carbon footprint from these industries.This study quantified GHG emissions from aquaculture and mariculture by four source phases(feed,energy use,nitrous oxide and fertilizers),and then analyzed the carbon footprint of each of these phases for GHG production of nine major species groups over the past ten years to show the spatial distribution of GHG emissions from aquaculture and mariculture in China.Our results showed that the production of feed materials contributed most to the GHG emissions and found that crop energy use,crop land use changes(LUC),fertilizer production,crop nitrous oxide production and rice methane production were the main sources of feed emissions.The total GHG emissions of the nine species groups were 112 Mt(10^(9) kg)CO_(2)e,the nine species accounting for approximately 86%of aquaculture and mariculture production.GHG emissions of cyprinids had the highest contribution at 47%.Spatial analysis based on our study showed Guangdong,Hubei,Jiangsu and Shandong had the highest GHG emissions of all the provinces in this study,and they accounted for approximately 46%of all emissions.The regional Gross Domestic Product(GDP)was significantly positively correlated with GHG emissions in every province,with a correlation coefficient higher than 0.6.Our results showed for the first time the relationship between the relative production by species composition and spatial distribution of GHG emissions from aquaculture and mariculture in China.Our findings provide the scientific basis for reduction of GHG emissions within a broader context of expanding aquaculture in the future. | Congjun Xu Guohuan Su Kangshun Zhao Xiaoqi Xu Ziqi Li Qiang Hu Ying Xue Jun Xu | 2022 | Water Biology and Security2022，1，3： | 1 |
| 6 | Accurate calibration method for a structured light system 显示文摘 | Li Zhongwei Shi Yusheng Wang Congjun | 2008 | Optical Engineering2008，47，5： | 1 |
| 7 | Complex Object 3D Measurement Based on Phase -shifting and a Neural Network显示文摘 | Li Zhongwei Shi Yusheng Wang Congjun | 2009 | Optics Com munications2009，282，： | 1 |
| 8 | Characterization of the rumen mierobiota of pre-ruminant calves using metagenomic tools 显示文摘 | Li R W Erin E Connor Congjun Li | 2012 | Environ mental Microbiology2012，14，1： | 1 |
| 9 | 3-D shape measure- ment of complex objects by combining color-coded fringe and neural net- works 显示文摘 | QIN Dahui LI Zhongwei WANG Congjun | 2009 | Tsinghua Science and Technology2009，14，1： | 1 |
| 10 | Generalized Well-Posedness and Stability of Solutions in Set Optimization显示文摘The aim of this paper is to investigate the well-posedness and stability in set optimization.The notion of generalized well-posedness for set optimization problems is introduced using the embedding technique for the first time.Some criteria and characterizations of this type of well-posedness are derived.Sufficient conditions are also given for this type of well-posedness.Moreover,by virtue of a generalized Gerstewitz’s function,the equivalent relation between this type of well-posedness and the generalized well-posedness of a scalar optimization problem is established.Finally,the upper semi-continuity and lower semi-continuity of weak efficient solution mappings for parametric set optimization problems are investigated under some suitable conditions. | Congjun ZHANG Zhiwei WANG Sai LI | 2022 | Journal of Mathematical Research with Applications2022，42，6： | 0 |
| 11 | Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling显示文摘Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity inhibitors.Here,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus sp.C1.HN-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte death.This protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional regulation.Knockdown of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown hepatocytes.Notably,the ER stress and lipotoxicity amelioration was associated with PLA2.Both HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated lipotoxicity.In contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of HN-001.Additionally,HN-001 treatment suppressed the downstream pro-apoptotic JNK pathway.In vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and fibrogenesis.These effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling suppression.These data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates. | Yong Rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang | 2024 | Acta Pharmaceutica Sinica B2024，14，1： | 0 |
| 12 | Stroke Risk Assessment Decision-Making Using a Machine Learning Model:Logistic-AdaBoost显示文摘Stroke is a chronic cerebrovascular disease that carries a high risk.Stroke risk assessment is of great significance in preventing,reversing and reducing the spread and the health hazards caused by stroke.Aiming to objectively predict and identify strokes,this paper proposes a new stroke risk assessment decision-making model named Logistic-AdaBoost(Logistic-AB)based on machine learning.First,the categorical boosting(CatBoost)method is used to perform feature selection for all features of stroke,and 8 main features are selected to form a new index evaluation system to predict the risk of stroke.Second,the borderline synthetic minority oversampling technique(SMOTE)algorithm is applied to transform the unbalanced stroke dataset into a balanced dataset.Finally,the stroke risk assessment decision-makingmodel Logistic-AB is constructed,and the overall prediction performance of this new model is evaluated by comparing it with ten other similar models.The comparison results show that the new model proposed in this paper performs better than the two single algorithms(logistic regression and AdaBoost)on the four indicators of recall,precision,F1 score,and accuracy,and the overall performance of the proposed model is better than that of common machine learning algorithms.The Logistic-AB model presented in this paper can more accurately predict patients’stroke risk. | Congjun Rao Mengxi Li Tingting Huang Feiyu Li | 2024 | Computer Modeling in Engineering & Sciences2024，139，4： | 0 |
| 13 | Impacts of species depletion on the food web structure of a marine ecosystem based on topological network analysis显示文摘Single-species management ignores the interactions between species,and ecosystem-based fisheries management(EBFM)has become a main method to fisheries management.Understanding food web structures and species interactions is essential for the implementation of EBFM and maintenance of ecosystem functions.Overfishing is one of the main reasons behind the depletion,which could even lead to the depletion of some target species in local areas.So understanding the impacts of species depletion on food web structures is important for the implementation of EBFM.The impacts of species depletion can be transmitted through the food web and cause the local extinction of both target and non-target species.In this study,topological network analysis was applied to examine the impacts of species depletion on the food web structure of Haizhou Bay.Results showed that fine crayfish Leptochela gracilis,squid Loligo sp.,and Japanese snapping shrimp Alpheus japonicus have the highest numbers of outgoing links(48,32 and 31 respectively);thus,these species may be considered key prey species.Whitespotted conger Conger myriaster,fat greenling Hexagrammos otakii,and bluefin gurnard Chelidonichthys kumu were key predators with the highest number of incoming links(37,36 and 35 respectively).The competition graphs derived from the Haizhou Bay food web were highly connected(more than 40%predators sharing over 10 common prey species),and showed close trophic interaction between high trophic level fishes.Simulation analysis showed that the food web structure has small changes to the depletion of species in a highly complex food web.The most-connected target species did not necessarily indicate high structural importance;however,some species with low connectivity may demonstrate stronger trophic interactions and play important ecological roles in the food web.But most species were more sensitive to the depletion of the most-connected target species than other target species(for instance,for zooplankton,closeness centrality 13.876 in D6,but closeness centrality 82.143 in original food web).Therefore,EBFM should focus on the most-connected target species,but also on those species with few but strong links and feeding relationships in the food web. | Congjun Xu Jun Xu Fan Li Yiping Ren Ying Xue | 2023 | Acta Oceanologica Sinica2023，42，11： | 0 |
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