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| 1 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 2 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 3 | CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors显示文摘 | Alonso-Camino V Sanchez-Martin D Compte M | 2013 | Mol Mater Nucleic Acids2013，2，： | 1 |
| 4 | Immunothera- peutic organoids: a new approach to cancer treatment 显示文摘 | Compte M Nunez-Prado N Sanz L | 2013 | Biomatter2013，3，23： | 1 |
| 5 | Selection of functional human antibodies from retroviral display libraries 显示文摘 | URBAN J H SCHNEIDER R M COMPTE M | 2005 | Nucleic Acids Res2005，33，4： | 1 |
| 6 | Selection of functional human antibodies from retroviral display libraries显示文摘 | Urban JH Schneider RM Compte M | 2005 | Nucleic Acids Res2005，33，4： | 1 |
| 7 | Li- popolysaccharide activates Toll - like receptor 4 ( TLR4 ) - media- ted NF - KB signaling pathway and proinflammatory response in hu- man pericytes显示文摘 | Guijarro - Muftoz I Compte M Alvarez - Cienfuegos A | 2014 | J Biol Chem2014，289，4： | 1 |
| 8 | Inhibition of tumor growthin vivo by in situ secretion of bispecific anti-CEA x anti-CD3 dia-bodies from lentivirally transduced human lymphocytes显示文摘 | Compte M Blanco B Serrano F | 2007 | Canc-er Gene Ther2007，14，： | 1 |
| 9 | G-protein beta 3-subunit gene variant, blood pressure and erythrocyte sodium/lithium countertransport in essential hypertension显示文摘 | Poch E Gonzalez-Nunez D Compte M | 2002 | Br J Biomed Sci2002，59，2： | 1 |
| 10 | Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes 显示文摘 | Compte M Blanco B Serrano F | 2007 | Cancer Gene Ther2007，14，4： | 1 |
| 11 | Prevalence of gastroesophageal reflux in Asthma显示文摘 | Compte L Garrigues V Perpian M | 2000 | J Asthma2000，37，2： | 1 |
| 12 | Long-term evaluation of immune response to hepatitis B vaccine in 136 patients undergoing hemodialysis显示文摘 | Pin M Compte MT Angelet P | 2009 | Nefrologia January2009，29，5： | 1 |
| 13 | A simple insulin-nutrition protocol for fight glycemic control in critical illness:development and protocol comparison显示文摘 | Lonergan T Le Compte A Willacy M | 2006 | Diabetes Technol Ther2006，8，2： | 1 |
| 14 | Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes显示文摘 | Compte M Blanco B Serrano F | | 0，，04： | 1 |
| 15 | Lymphocyte display:a novel antibody selection platform based on T cell activation显示文摘 | Alonso-Camino V Sanchez-Martin D Compte M | 2009 | PLoS One2009，4，9： | 1 |
| 16 | Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds显示文摘 | Compte M Cuesta AM Sdnchez-Martin D | 2009 | Stem Cells2009，27，3： | 1 |
| 17 | Li- popolysaecharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatoryresp onse in hu- man pericytes显示文摘 | Guijarro-Mufioz I Compte M Alvarez-Cienfuegos A etal | 2014 | J Biol Chem2014，289，4： | 1 |
| 18 | Tumor immunotherapy using gene-modified human menchymal stem cells loaded into synthetic extracellular matrix scaffolds显示文摘 | Compte M Cuesta AM Slnchez-Martin D | 2009 | Stem Cells2009，27，： | 1 |
| 19 | Lipopo- lysaccharide activates Toll-like receptor 4 ( TLR4 ) -mediated NF- KB signaling pathway and proinflammatory response in human pericytes显示文摘 | Guijarro-Mufioz I Compte M Alvarez-Cienfuegos A | 2014 | J Biol Chem2014，289，4： | 1 |
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