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| 1 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 2 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 3 | CARbodies: Human Antibodies Against Cell Surface Tumor Antigens Selected From Repertoires Displayed on T Cell Chimeric Antigen Receptors显示文摘 | Alonso-Camino V Sanchez-Martin D Compte M | 2013 | Mol Mater Nucleic Acids2013，2，： | 1 |
| 4 | Capacity Constraints, Mergers and Collusion 显示文摘 | Compte O F Jenny PRey | 2002 | European Economic Review Vol 462002，，1： | 1 |
| 5 | The coalitional Nash bargaining solution 显示文摘 | Compte 0 Jehiel P | 2010 | Econometrica2010，78，： | 1 |
| 6 | Capacity constraints, mergers and collusion显示文摘 | Compte O Jenny F Rey P | 2002 | European Economic Review2002，46，： | 1 |
| 7 | Immunothera- peutic organoids: a new approach to cancer treatment 显示文摘 | Compte M Nunez-Prado N Sanz L | 2013 | Biomatter2013，3，23： | 1 |
| 8 | Selection of functional human antibodies from retroviral display libraries 显示文摘 | URBAN J H SCHNEIDER R M COMPTE M | 2005 | Nucleic Acids Res2005，33，4： | 1 |
| 9 | Selection of functional human antibodies from retroviral display libraries显示文摘 | Urban JH Schneider RM Compte M | 2005 | Nucleic Acids Res2005，33，4： | 1 |
| 10 | Li- popolysaccharide activates Toll - like receptor 4 ( TLR4 ) - media- ted NF - KB signaling pathway and proinflammatory response in hu- man pericytes显示文摘 | Guijarro - Muftoz I Compte M Alvarez - Cienfuegos A | 2014 | J Biol Chem2014，289，4： | 1 |
| 11 | Corruption and competition in procurement显示文摘 | Compte O Lambert-Mogiliansky A Verdier T | 2005 | RAND Journal of Economics2005，36，1： | 1 |
| 12 | The effects of maxillary expansion using a quad-helix appliance during the deciduous and mixed dentitions 显示文摘 | Bell RA Le Compte EJ | 1981 | Am J Orthod1981，79，2： | 1 |
| 13 | Usefulness of carcinoembryonic antigen determination in bronchoalveolar lavage fluid: a comparative study among patients with peripheral lung cancer, pneumonia, and healthy individuals 显示文摘 | de Diego A Compte L Sanchis J | 1991 | Chest1991，100，4： | 1 |
| 14 | Non-equilibrium thermodynamics and anomalous diffusion显示文摘 | Compte A Jou D | 1996 | J Phys A1996，29，15： | 1 |
| 15 | Mechanism for top-down control of working memory capacity显示文摘 | Edin F Klingberg T Johansson P McNab F Tegnér J & Compte A | | 0，，： | 1 |
| 16 | Corruption and competition in procurement auctions 显示文摘 | Compte O Lambert-Mogiliansky A Verdier T | 2005 | Rand Journal of Economics2005，36，1： | 1 |
| 17 | Anomalous diffusion in linear shear flows显示文摘 | Compte A Jou D Katayama Y | 1997 | J Phys A1997，30，4： | 1 |
| 18 | Wound healing in radiated skin:pathophysiology and treatment options显示文摘 | Olascoaga A Vilar Compte D Poitevin Chac(o)n A | 2008 | Int Wound J2008，5，2： | 1 |
| 19 | Continuous time random walks on moving fluids显示文摘 | COMPTE A | 1997 | Physical Review E1997，55，6： | 1 |
| 20 | Diagnostic value of carcinoembryonic antigen inbronchoalveolar lavage fluid of peripheral lung cancer显示文摘 | de Diego A Compte L Sanchis J | 1990 | Chest1990，97，3： | 1 |
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