|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 口服非洲刺李后人的血清对不同良性前列腺细胞的生物效应显示文摘非洲刺李(太得恩。)是一种普遍用于治疗有症状良性前列腺增生的草药。该药物的活性物质还没有被鉴定出来,因此,确定其血药浓度是不可能的。对该药的疗效目前存在一些争议,因而我们决定用摄入和未摄入非洲刺李的人的血清在体外处理前列腺细胞,观察其对前列腺细胞生长的作用。我们使用的是原代培养和器官培养的良性成纤维(WPMY)前列腺细胞和上皮(PNT2)前列腺细胞。我们也使用了新鲜的良性前列腺组织。研究发现,摄入非洲刺李的人血清可以减少原代培养细胞、器官培养细胞以及WPMY细胞的增殖,但不影响PNT2细胞的增殖。我们还利用AffymetrixHG.U1332.0PLUS芯片分析了处理血清对WPMY细胞基因表达的影响。转录子分析结果显示参与肿瘤抑制通路的多个基因的表达发生了上调,而一些参与炎症及氧化应激通路的基因表达发生了下调。口服非洲刺李可使药物的活性物质达到足够的血清水平,从而抑制成纤维前列腺细胞的增殖。此抑制作用与转录子的改变有关。 | Stephane Larre Philippe Camparo Eva Comperat Delphine Boulbes Mohammed Haddoum Sylvain Baulande Pascal Soularue Pierre Costa Olivier Cussenot | 2012 | Asian Journal of Andrology2012，14，3： | 2 |
| 2 | Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis 显示文摘 | Audouin J Comperat E Le Tourneau A | 2003 | Int J Surg Pathol2003，11，4： | 1 |
| 3 | Tissue microarray technology:validation in colorectal carcinoma and analysis of p53,hMLH1,and hMSH2immunohistochemical expression显示文摘 | Jourdan F Sebbagh N Comperat E | 2003 | Virchows Arch2003，443，2： | 1 |
| 4 | European guidelines on upper tract urothelial carcinomas: 2013 update显示文摘 | Roupr6t M Babjuk M Comperat E | 2013 | EurUrol2013，63，6： | 1 |
| 5 | Mucinous tubular and spindle cell carcinoma: a report of 15cases and a review of the literature 显示文摘 | Ferlicot S Allory y Comperat E | 2005 | Virchows Arch2005，447，6： | 1 |
| 6 | Mucinous tubular and spindle cell carcinoma:a report of 15 cases and a review of the literature显示文摘 | Ferlicot S Allory Y Comperat E | 2005 | Virchows Arch2005，447，6： | 1 |
| 7 | Benign mixed epithelial and stromal tumor of the kidney (MEST) with cytogenetic alteration显示文摘 | Comperat E Couturier J Peyromaure M | 2005 | Pathol Res Pract2005，200，1112： | 1 |
| 8 | Myeloid sarcoma:clinical and morphologie criteria useful for diagnosis 显示文摘 | J Audouin E Comperat AL Tourneau | 2003 | International Journal of Surgical Pathology2003，11，4： | 1 |
| 9 | EAUguidelines on muscle-invasive and metastatic bladder cancer:summary of the 2013guidelines显示文摘 | Witjes J A Comperat E Cowan N C | 2014 | Eur Urol2014，65，4： | 1 |
| 10 | EAU guidelines on muscle - invasive and metastatic bladder cancer: summary of the 2013 guidelines显示文摘 | Witjes JA Comperat E Cowan NC | 2014 | Eur Urol2014，65，4： | 1 |
| 11 | Tissue microarray technology : validation in colorectal carcinoma and analysis of p53, hMLH1, and hMSH2 immunohistoehemical expression 显示文摘 | Jourdan F Sebbagh N Comperat E | 2003 | Virchows Arch2003，443，2： | 1 |
| 12 | Metastin ( Kiss-1 ) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder显示文摘 | Nieolle G Comperat E Nicolaew N | 2007 | Ann Oncol2007，18，3： | 1 |
| 13 | Metastin (KISS-1) and metastin-coupled receptor (GPR54) expression in transitional cell carcinoma of the bladder显示文摘 | NicoUe G Comperat E Nicolaiew N | 2007 | Ann Oncol2007，18，3： | 1 |
| 14 | Histologic features in the urinary bladder wall affected from neurogenic overactivity - a comparison of inflammation, oedema and fibrosis with and with- out injection of botulinum toxin type A 显示文摘 | Comperat E Reitz A Delcourt A | 2006 | European urology2006，50，5： | 1 |
| 15 | Tissue microarray technology:validation in colorectal carcinoma and analysis of p53,hMLH1,and hMSH2 immunohistochemical expression显示文摘 | JOURDAN F SEBBAGH N COMPERAT E | 2003 | Virchows Arch2003，443，2： | 1 |
| 16 | European guidelines on upper tract urothelial carcinomas: 2013 update显示文摘 | Roupret M Babjuk M Comperat E | 2013 | Eur Urol2013，63，6： | 1 |
| 17 | Upper urinary tract urothelial cell carcinomas and other urological malignancies involved in the he- reditary nonpolyposis eoloreetal cancer ( lynch syndrome ) tumor spec- trum显示文摘 | Roupret M Yates DR Comperat E | 2008 | Eur Urol2008，54，6： | 1 |
| 18 | Mucinous tubular and spindle cell carcinoma:a report of 15 cases and a review of the literature显示文摘 | Ferlicot S Allory Y Comperat E | 2005 | Virchows Arch2005，18，1： | 1 |
| 19 | Oncological outcomes in patients undergoing radical nephrectomy and vena cava thrombectomy for renal cell carcinoma with venous extension: A single-centre experience显示文摘 | J. Parra S.J. Drouin V. Hupertan E. Comperat M.O. Bitker M. Rouprêt | 2011 | European Journal of Surgical Oncology2011，，5： | 1 |
| 20 | European Guidelines on Upper Tract Urothelial Carcinomas: 2013 Update显示文摘 | Roupret M Babjuk M Comperat E | 2013 | Eur Urol2013，63，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员