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| 1 | Diet,ageing and genetic factors in the pathogenesis of diverticular disease显示文摘Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK.This high prevalence ranks it as one of the most common bowel disorders in western nations.The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum.Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality.In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber.In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development.We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal.We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease. | Daniel Martin Commane Ramesh Pulendran Arasaradnam Sarah Mills John Cummings Mathers Mike Bradburn | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 2 | Defective TNF-alphainduced apoptosis in STAT1-null cells due to low constitutive levels of caspases显示文摘 | Kumar A Commane M Flickinger T W | 1997 | Science1997，278，5343： | 1 |
| 3 | Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases显示文摘 | Kumar A Commane M Flickinger T W | 1997 | Science1997，278，： | 1 |
| 4 | 查看详情显示文摘 | Comman C R Colpas G J Hoeschele J D | | 0，，： | 1 |
| 5 | Actl, an NF-kappa B-activating protein显示文摘 | Li X Commane M Nie H | 2000 | Proc Natl Acad Sci USA2000，97，10： | 1 |
| 6 | Laparoscopic removal of a perforating intrauterine device mimicking chronic appendicitis显示文摘 | Brunner SM Comman A Gaetzschmann P | 2008 | J Laparo Adv Sur Tech2008，18，4： | 1 |
| 7 | Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases显示文摘 | Commane M Flickinger TW | 1997 | Science1997，278，5343： | 1 |
| 8 | The potential mechanisms involved in the anticarcinogenic action of probiotics显示文摘 | COMMANE D HUGHES R SHORTT C | 2005 | Mutat Res2005，591，12： | 1 |
| 9 | A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis显示文摘 | Arasaradnam R P Commane D M Bradburn D | 2008 | Epigenetics2008，3，4： | 1 |
| 10 | Formation of mutagens in beef and beef extract during cooking显示文摘 | COMMANER B VITHAYATHIL A J Dolara P | 1978 | Science1978，201，4359： | 1 |
| 11 | Defective TNF- alpha- induced apoptosis in STAT1 - null cells due to low constitutive levels of caspases显示文摘 | KUMAR A COMMANE M FLICKINGER T W | 1997 | Science1997，278，5343： | 1 |
| 12 | Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice显示文摘 | Koman IE Commane M Paszkiewicz G | 2012 | Cancer Prev Res(Phila)2012，5，8： | 1 |
| 13 | 查看详情显示文摘 | Commans S B(o)ckA | | 0，，： | 1 |
| 14 | Genomic analyses of the micresporidian Nosema ceranae,an emergent pathogen of honey bees显示文摘 | Comman R Chen YP Schatz M | 2009 | PLOS Pathog2009，5，10： | 1 |
| 15 | IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B显示文摘 | Qian Y Commane M Ninomiya-Tsuji J | 2001 | J Biol Chem2001，276，41： | 1 |
| 16 | IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK) 显示文摘 | Li X Commane M Jiang Z | 2001 | Proc Natl Acad Sci USA2001，98，8： | 1 |
| 17 | Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa 显示文摘 | Tapp H S Commane D M Bradburn D M | 2013 | Aging Cell2013，12，1： | 1 |
| 18 | Actl, an NFKB-activating protein显示文摘 | Li X Commane M Nie H | 2000 | Proc Nat] Acad Sci USA2000，97，10： | 1 |
| 19 | Actl, an NF-kappa B-activating protein显示文摘 | Li X Commane M Nie H | 2000 | Proc Natl Acad Sci2000，97，10： | 1 |
| 20 | Act1,an NF-kappa B-activating protein显示文摘 | Li X Commane M Nie H | | 0，，： | 1 |
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