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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia显示文摘There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining 'anti-inflammatory' medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD. | Craig A Friesen Jennifer V Schurman Jennifer M Colombo Susan M Abdel-Rahman | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 3 | Temporomandibular joint loading patterns related to joint morphology: a theoretical study 显示文摘 | Colombo V Palla S Gallo LM | 2008 | Cells Tissues Organs2008，187，4： | 1 |
| 4 | Driven gait orthosis for improvement of locomotor training in paraplegic patient显示文摘 | Colombo G Wirz M Dietz V | | 0，，： | 1 |
| 5 | Stereometric assessment of TMJ space variation by occlusal splints 显示文摘 | Ettlin DA Mang H Colombo V | 2008 | J Dent Res2008，87，9： | 1 |
| 6 | A roadmap for graphene显示文摘 | Novoselov K S Falko V I Colombo L | 2012 | Nature2012，490，： | 1 |
| 7 | Morphologicalanalysis of female gametophyte development in the bellstk shpl shp2 mutant显示文摘 | Battaglia R Brambilla V Colombo L | 2008 | Plant Biosyst2008，142，： | 1 |
| 8 | A roadmap for graphene显示文摘 | Novoselov K S Fal V I Colombo L | 2012 | Nature2012，490，7419： | 1 |
| 9 | The use of tenax for the extraction of pesticides and polychlorinated biphenyls from water显示文摘 | Puccetti G Colombo R J | 1976 | J Chromatogr1976，125，： | 1 |
| 10 | Three-dimensional modeling of inductively coupled plasma torches显示文摘 | Bernardi D Colombo V Ghedini E | 2003 | The Euro pean Physical Journal D2003，27，： | 1 |
| 11 | Morphologicalanalysis of female gametophyte development in the bellstk shpl shp2 mutant显示文摘 | Battaglia R Brambilla V Colombo L | 2008 | Plant Biosyst2008，142，： | 1 |
| 12 | Joining of reaction-bonded silicon carbide using a preceramic polymer显示文摘 | COLOMBO P SGLAVO V PIPPEL E | 1998 | Journal of Materials Science1998，33，： | 1 |
| 13 | Genetic andmolecular interactions between BELLI and MADS Boxfactors support ovule development in Arabidopsis 显示文摘 | Brambilla V Battaglia R Colombo M | 2007 | Plant Cell2007，19，： | 1 |
| 14 | Aroadmap for graphene 显示文摘 | NOVOSELOV K S FAL'KO V I COLOMBO L | 2012 | Nature2012，490，： | 1 |
| 15 | Intestinal per- foration following blunt abdominal trauma in patients with pre-existing inguinal hernia 显示文摘 | Neuhaus V Turina M Colombo G | 2009 | Chirurg2009，80，3： | 1 |
| 16 | Improved CO2 Capture from Flue Gas by Basic Sites, Charge Gradients, and Missing Linker Defects on Nickel Face Cubic Centered MOFs显示文摘 | López-Maya E Montoro C Colombo V | 2014 | Adv Funct Mater2014，24，39： | 1 |
| 17 | Degradation of 2, 4, 6 - trichlorophenol by a specialized organism and by indige- nous soil microflora : bioaugmentation and self - remediability for soil restoration 显示文摘 | Andreoni V Baggi G Colombo M | 1998 | Letters in applied microbiology1998，27，2： | 1 |
| 18 | Driven gait orthosis for improve- ment of locomotor training in paraplegic patients 显示文摘 | Colombo G Wirz M Dietz V | 2001 | Spinal Cord2001，39，5： | 1 |
| 19 | Joining of reaction-bonded silicon carbide using a preceramic polymer显示文摘 | Colombo P Sglavo V Pippel E | 1998 | Journal of Materials Science1998，33，： | 1 |
| 20 | Oncoplastic surgery for the treatment of breast cancer 显示文摘 | Colombo G Dellacasa I Ruvolo V | 2009 | Minerva Ginecol2009，61，5： | 1 |
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