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您的检索式：作者名="Collins M.W."
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| 1 | 生理参数及药物注射方式对球形实体肿瘤中药物输运的影响显示文摘目的研究球形实体肿瘤中生理参数对药物输运的影响,以及探讨有较好效果的药物注射方式。方法设肿瘤中毛细血管网成球对称分布,肿瘤中的毛细血管表面积和肿瘤体积之比为半径的函数。肿瘤间质为多孔介质,化学药物透过毛细血管壁进入肿瘤间质,在肿瘤间质中输运满足扩散方程。肿瘤外正常组织富含血管和淋巴,药物能被淋巴管吸收,药物输运采用改进的药代动力学模型。用肿瘤中各部位药物浓度维持在最小药物浓度MEC水平以上的时间曲线面积(AUC)来衡量药物的效果。结果增大肿瘤间质中毛细血管对药物的通透性P,提高药物在肿瘤间质的扩散系数D,AUC的值均增大。在给出的六种给药方式中,分时段连续滴注和等时间间隔一次性注射的给药方式,它们的AUC值最大。结论增大肿瘤间质中毛细血管对药物的通透性,提高药物在肿瘤间质的扩散系数,以及采用分时段连续滴注和等时间间隔一次性注射的给药方式,有利于肿瘤的治疗。 | 浏丹 许世雄 Collins M.W. 蒋雨平 王坚 林原 | 2006 | 医用生物力学2006，21，1： | 3 |
| 2 | NUMERICAL SIMULATION OF HEMODYNAMICS IN THE HOST BLOOD VESSEL AND MICROVASCULAR NETWORK GENERATED FROM TUMOR-INDUCED ANGIOGENESIS显示文摘Numerical simulation of hemodynamics under the combined effects of both the host blood vessel and the microvascular network,which is based on a 2-D tumor inside and outside vascular network generated from a discrete mathematical model of tumor-induced angiogenesis, is performed systemically. And a “microvascular network — transport across microvascular network—flow in interstitium” model is developed to study the flow in solid tumor. Simulations are carried out to examine the effects of the variations of the inlet Reynolds number in the host blood vessel, the hydraulic conductivity of the microvascular wall, and interstitial hydraulic conductivity coefficient on the fluid flow in tumor microcirculation. The results are consistent with data obtained in terms of physiology. These results may provide some theoretical references and the bases for further clinical experimental research. | ZHAO Gai-ping WU Jie XU Shi-xiong COLLINS M.W. JIANG Yu-ping WANG Jian | 2006 | Journal of Hydrodynamics2006，18，6： | 2 |
| 3 | Association between triglyceride and high-density lipoprotein cholesterol change following fibrate therapy显示文摘 | M.W. Collins C.S. K?nig A. Abbas C. Jewkes A.F. Jones S. Ramachandran | 2014 | Diabetes & Metabolic Syndrome: Clinical Research & Reviews2014，，4： | 1 |
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