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| 1 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 2 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 3 | Is liver biopsy necessary in the management of alcoholic hepatitis?显示文摘Acute alcoholic hepatitis(AAH)is characterised by deep jaundice in patients with a history of heavy alcohol use,which can progress to liver failure.A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure.Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered.Liver biopsy remains the only reliable method to make an accurate diagnosis.However,there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy.We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH.In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor.Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions,we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology.Italso adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology.Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH. | Ashwin D Dhanda Peter L Collins C Anne McCune | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | Video capsule endoscopy in inflammatory bowel disease显示文摘Video capsule endoscopy(VCE) has evolved to become an important tool for the non-invasive examination of the small bowel, which hitherto had been relatively inaccessible to direct visualisation. VCE has beenshown to play a role in monitoring the activity of small bowel Crohn's disease and can be used to assess the response to anti-inflammatory treatment in Crohn's disease. For those patients with Crohn's disease who have undergone an intestinal resection, VCE has been assessed as a tool to detect post-operative recurrence. VCE may also aid in the reclassification of patients with a diagnosis of Inflammatory Bowel Disease Unclassified to Crohn's disease. The evolution of colon capsule endoscopy(CCE) has expanded the application of this technology further. The use of CCE to assess the activity of ulcerative colitis has been described. This advance in capsule technology has also fuelled interest in its potential role as a minimally invasive tool to assess the whole of GI tract opening the possibility of its use for the panenteric assessment of Crohn's disease. VCE is a safe procedure. However, the risk of a retained capsule is higher in patients with suspected or confirmed Crohn's disease compared with patients having VCE examination for other indications. A retained video capsule is rare after successful passage of a patency capsule which may be utilised to pre-screen patients undergoing VCE. This paper describes the use of VCE in the assessment of inflammatory bowel disease. | Paul D Collins | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，14： | 2 |
| 6 | A l H NMR study of the DNA binding of ruthenium( Ⅱ) polypyridyl complexes 显示文摘 | COLLINS J SLEEMAN A D ALDRICH-WRIGHT J R | 1998 | Inorg Chem1998，37，： | 1 |
| 7 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 8 | Strut-and-tie models for design of pile caps: an experimental study 显示文摘 | Adebar P Kuchma D Collins M P | 1992 | ACI Structural Journal1992，87，1： | 1 |
| 9 | Intra - institutional factors that influence accounting research productivity 显示文摘 | Bucheit S Collins A B Collins D L | 2001 | The Journal of Applied Business Research2001，17，2： | 1 |
| 10 | Absence of p-selectin,but not intercellular adhesion molecule-1,attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice显示文摘 | MANKA D COLLINS R G LEY K | 2001 | Circulation2001，103，7： | 1 |
| 11 | Phosphorus losses in irrigation from fertilized pasture显示文摘 | Austin N R Prendergast J B Collins M D | 1996 | Journal of Environ- mental Quality1996，25，： | 1 |
| 12 | Pattern of excretion of urinary steroid metabolites during the ovarian cycle and pregnancy in the marmoset monkey显示文摘 | EASTMAN SAK MAKAWITI D W COLLINS W P | 1984 | Journal of Endocrinology1984，102，： | 1 |
| 13 | Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological features显示文摘 | Butler D Collins C Mabruk M | 2000 | J Pathol2000，192，： | 1 |
| 14 | Timing intrauterine insemination either 33 or 39 hours after administration of human chorionic gonadotropin yields the same pregnancy rates as after superovulation therapy显示文摘 | Claman P Wilikie V Collins D | 2004 | Fertil Steril2004，82，1： | 1 |
| 15 | QTL for field resistance to late blight in potato are strongly correlated with ma- turity and vigor显示文摘 | Collins A Milbourne D Ramsay L | 1999 | Mol Breed1999，5，： | 1 |
| 16 | The Discovery and Reporting of Internal Control Deficiencies Prior to SOX - mandated Audits 显示文摘 | Ashbaugh-Skaife Collins H Kinney D | 2007 | Journal of Accounting and Economics2007，，44： | 1 |
| 17 | Organizational Harm, Legal Condemna- tion and Stakeholder Retaliation: A Typology, Re search Agenda and Application显示文摘 | COLLINS D | 1989 | Journal of Busi- ness Ethics1989，8，1： | 1 |
| 18 | Colon cancer: a civilization disorder显示文摘 | Watson A J Collins P D | 2011 | Dig Dis2011，29，2： | 1 |
| 19 | Isolation of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gno-tobiotic pigs 显示文摘 | Collins J E Benfield D A Christianson W T | 1992 | Journal of Veterinary Diagnostic Investigation1992，4，2： | 1 |
| 20 | Strategic Human Resource Practices,Top Management Team Social Networks,and Firm Performance:The Role of Human Resource Practices in Creating Organizational Competitive Advantage显示文摘 | Collins C J Clark K D | 2003 | Academy of Management Journal2003，46，6： | 1 |
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