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| 1 | Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice显示文摘 | Collins Meredith A Bednar Filip Zhang Yaqing Brisset Jean-Christophe Galbán Stefanie Galbán Craig J Rakshit Sabita Flannagan Karen S Adsay N Volkan di Magliano Marina Pasca | 2012 | EN2012，，： | 3 |
| 2 | In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug:halofantrine显示文摘Objective:To formulate and evaluate in vitro,surface-modified solid lipid microspheres containing hal of antrine using lipid matrix formed from goat fat and a phospholipid(P90H). Methods:The model drug,hal of antrine in an increasing concentration of 1%,2%,3%,4% and 5%w/w was incorporated into surface-modified solid lipid microspheres formulated by hot homogenization.Effect of drug concentration on the encapsulation efficiency was studied. The dispersion was evaluated using particle size,particle morphology,pH and encapsulation efficiency.The drug formulation with highest encapsulation efficiency was selected and used for the release studies and compared with the release from a commercial dosage form(Halfan~? 250 mg tablet,Claxo-Smithkline,Mayenne France) using simulated gastric fluid(SGF pH 1.2), simulated intestinal fluid(SIF pH 7.2) and phosphate buffer(pH 6.8) as biorelevant media. Results were analyzed statistically and the level of significance was taken to be P<0.05). Results:Discrete and spherical solid lipid microspheres were produced.The particle size of the dispersion was low(32.48-33.87μm) with minimal particle growth and high encapsulation efficiencies(86.8%-91.0%) after 3 months.The pH of the microspheres dispersion changed appreciably after 3 months.In vitro release result obtained revealed sustained and controlled drug release from the lipid microspheres compared with the tablet dosage form.Conclosions: Formulation of hal of antrine as solid lipid microspheres presents a better alternative to the conventional tablet formulation as the in vitro dissolution of the highly lipophilic hal of antrine was highly improved. | Anthony A Attama Collins N Igbonekwu | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，4： | 3 |
| 3 | Developing a global interconnected power system model显示文摘Decarbonizing the power sector is a necessary step towards a low-carbon future. Interconnecting power systems on different continents could be a method to contribute to such a future, by utilizing highly efficient renewable resources around the globe, while simultaneously providing additional benefits of power system integration. In this paper, we describe the process of constructing and simulating a global interconnected power system model with high technical and temporal resolution. Being the first of its kind on the global scale, this paper is designed to showcase the proof of concept as an intermediate step to a high resolution global model, by integrating an existing European power system model with the North-American continent. The work to date has been focused on testing the methodology and building up necessary knowledge to realistically simulate the functionality of a possible future global grid. Some initial results are analysed to support the viability of the model and the concept in general. Furthermore, key factors influencing the development and optimal performance of the global interconnected power system model are identified. | Maarten Brinkerink Paul Deane Seán Collins Brian Ó Gallachóir | 2018 | Global Energy Interconnection2018，1，3： | 2 |
| 4 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 5 | PPARa activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells显示文摘 | Marx N Sukhova GK Collins T | 1999 | Circulation1999，99，24： | 1 |
| 6 | Phosphorus losses in irrigation from fertilized pasture显示文摘 | Austin N R Prendergast J B Collins M D | 1996 | Journal of Environ- mental Quality1996，25，： | 1 |
| 7 | Surficial sediments of the Great Australian Bight:Facies dynamics and oceanography on a vast cool-water carbonate shelf显示文摘 | James N P Bone Y Collins L B | 2001 | Journal of Sedimentary Research2001，71，： | 1 |
| 8 | Effect of workmanship factors on traffic deck waterproofing systems显示文摘 | MAILVAQANAM N P COLLINS P G | 1997 | Indian Concrete Journal1997，71，12： | 1 |
| 9 | Outcomes Using Grafts from Donors after Cardiac Death显示文摘 | Doyle MB Collins K Vaehharajani N | 2015 | J Am Coll Surg2015，221，1： | 1 |
| 10 | Evolutionary relationships among scyphozoan jellyfish families based on complete taxon sampling and phylogenetic analyses of 18S and 28S ribosomal DNA显示文摘 | Bayha K M Dawson M N Collins A G | 2010 | Integr Cornp Biol2010，50，3： | 1 |
| 11 | Relationship between infective load of Helicobacter pyliri and reactive oxygen metabolite production in antral mucosa显示文摘 | Banatvala N Collins CE Sheaff MT | 1994 | Scand J Gastroenterol1994，29，1： | 1 |
| 12 | A Spanish Translation of the Walking Impairment Questionnaire Was Validated for Patients with Peripheral Arterial Disease显示文摘 | Collins T C Suarez-Almazor M Petersen N J | 2004 | J Clin Epidemiol2004，57，12： | 1 |
| 13 | Instability of short tandem repeats (microsatellites) in human cancer显示文摘 | Wooster R Cleton-Jansen AM Collins N | 1994 | Nat Genet1994，6，： | 1 |
| 14 | Elp1p,the yeast homolog of the FD disease syndrome protein,negatively regulates exocytosis inde-pendently of transcriptional elongation显示文摘 | Rahl P B Chen C Z Collins R N | 2005 | Mol Cell2005，17，6： | 1 |
| 15 | Nonlinear viscoelastic behavior of butadiene acrylonitrile copolymers filled with carbon black显示文摘 | Nakajima N Bowerman H H Collins E A | 1978 | Rubber Chemistry and Technology1978，51，2： | 1 |
| 16 | Smoking and cardio- vascular outcomes in dialysis patients: the United States Renal Data System Wave 2 study显示文摘 | FOLEY R N HERZOG C A COLLINS A J | 2003 | Kidney Int2003，63，4： | 1 |
| 17 | Large-scale reorganization in the so- matosensory cortex and thalamus after sensory loss in macaque monkeys 显示文摘 | Jain N Qi HX Collins CE Kaas JH | 2008 | J Neurosei2008，28，11： | 1 |
| 18 | Dual-energy subtraction chest radiography: what to look for beyond calcified nodules 显示文摘 | Kuhlman J E Collins J Brooks G N | 2006 | Radiographys2006，26，1： | 1 |
| 19 | Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B 显示文摘 | Gara N Zhao X Collins MT | 2012 | Aliment Pharmaeol Ther2012，35，11： | 1 |
| 20 | Convolution Kernels for Natural Language显示文摘 | M Collins N Duffy | 2002 | Advancea in Neural Info Proc Sys2002，，14： | 1 |
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