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| 1 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 2 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 3 | Resonance light scattering: a new technique for studying chromophore aggregation 显示文摘 | PASTERNACK R F COLLINGS P J | 1995 | Science1995，269，： | 1 |
| 4 | Modulation of inflammatory response by hippocampus of rats exposed to cerebral ischemia/reperfusion显示文摘 | Coll the PPAR ino M Aragno M Ma oxidative stress -gamma agonists in stro and the cola R et a7 | 2006 | Eur J Pharmacol2006，530，： | 1 |
| 5 | Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells 显示文摘 | Coll T Eyre E Rodriguez-Calvo R | 2008 | J Biol Chem2008，283，11： | 1 |
| 6 | Selenium in human health and disease 显示文摘 | BAO Y BROADLEY M R COLLINGS R | 2011 | Antioxid Redox Signal2011，14，7： | 1 |
| 7 | Porphrin Assemblies on DNA as Studied by a Resonaee Light-Scattering Teehnique显示文摘 | Pasternack R F Bustamante C Collings P J | 1993 | J Am Chem Soc1993，115，13： | 1 |
| 8 | Transplanted liver: consequences of denervation for liver functions显示文摘 | Colle I Van VH Troisi R | 2004 | Anat Rec A Discov Mol Cell Evol Biol2004，280，1： | 1 |
| 9 | Porphyrin Assemblies on DNA as Studied by a Resonance Light-scattering Technique显示文摘 | Pasternack R F Bustmante C Collings P J | 1993 | J Am Chem Soc1993，115，： | 1 |
| 10 | Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide- induced cytokine production in adipocytes by lowering nuclear fac- tor-kappa B activity via extracellular signal-related kinase 1/2 显示文摘 | Rodriguez-Calvo R Serrano L Coll T | 2008 | Diabetes2008，57，： | 1 |
| 11 | Long-term treatment with a low-molecular-weight heparin administered subcutaneously compared with a vitamin K antagonist : subanalysis of patients with cancer 显示文摘 | ROMERA- VILLEGAS A MARTI- MESTRE X VILA- COLL R | 2015 | Med Clin(Barc)2015，144，1： | 1 |
| 12 | Porphyrin Assemblies on DNA as Studied by a Resonance Light-scattering Technique显示文摘 | Pasternack R F Bustamante C Collings D J | 1993 | J Am Chem Soc1993，115，13： | 1 |
| 13 | Arthropod Pest Resurgence: An Overview of Potential Mechanisms 显示文摘 | HARDIN M R BENREY B COLL M | 1995 | Crop Protection1995，14，1： | 1 |
| 14 | Predicting pulpectomy success and its relationship to exfoliation and succedaneous dentition 显示文摘 | Coll JA Sadrian R | 1996 | Pediatr Dent1996，18，1： | 1 |
| 15 | Purification and characterization of a phenoloxidase ( laccase from the lignin-degrading basidiomycete PM1 ( CECT2971 ) 显示文摘 | Coll P M Fernandez-Abalos J M Villanieva J R | 1993 | Appl Environ Microbiol1993，59，18： | 1 |
| 16 | Resonance light scattering: A new technique for studying chromophore aggregation显示文摘 | Pastenack R F Collings P J | 1995 | Science1995，269，： | 1 |
| 17 | Early extubation following cardiac surgery in a veterans population显示文摘 | London MJ Coll R J MaWhinney S | 1998 | Anesthesiology1998，88，： | 1 |
| 18 | MIMO multichannel beamforming: SER and outage using new eigenvalue distributions of complex noncentral Wishart matrices显示文摘 | COLLINGS I B GAO Xi Qi MCKAY M R | 2008 | IEEE Transactions on Communications2008，56，3： | 1 |
| 19 | The effective density and fractal dimension of particles emitted from a light - duty diesel ve- hicle with a diesel oxidation catalyst 显示文摘 | Olfert J S Symonds J P R Collings N | 2007 | Journal of Aerosol Sci- ence2007，38，26： | 1 |
| 20 | Resonance light scattering: a new technique for studying chromophore aggregation 显示文摘 | PASTERNACK R F COLLINGS P J | 1995 | Science1995，269，5226： | 1 |
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