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| 1 | Specific probiotics alleviate allergic rhinitis during the birch pollen season显示文摘AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these.METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L.acidophilus) NCFMTM (ATCC 700396) and Bifidobacterium lactis (B.lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo,starting prior to onset of the birch pollen season.Symptoms were recorded in a diary.Blood samples were taken for analysis of cytokines and eosinophils.Fecal samples were analysed for microbiota components,calprotectin and IgA.Nasal swabs were taken for analysis of eosinophils.RESULTS:The pollen season induced a reduction in Bifidobacterium,Clostridium and Bacteroides which could not be prevented by the probiotic intervention.During the intervention,significantly higher numbers of B.lactis 11.2×107 ± 4.2×107 vs 0.1×107 ± 0.1×107 bacteria/g feces (P<0.0001) and L.acidophilus NCFMTM 3.5×106 ± 1.3×106 vs 0.2×106 ± 0.1×106 bacteria/g feces (P<0.0001) were observed in the probiotic group compared to the placebo group.During May,there was a tendency for fewer subjects,(76.2% vs 95.2%,P=0.078) to report runny nose,while during June,fewer subjects,11.1% vs 33.3%,reported nasal blocking in the probiotics group (P =0.101).Concomitantly,fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group,57.1% vs 95% (P=0.013).Eye symptoms tended to be slightly more frequent in the probiotic group,12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P=0.066) during May.Fecal IgA was increased in the placebo group during the pollen season;this increase was prevented by the probiotics (P=0.028).CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition.The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa,and indicated a trend for reduced nasal symptoms. | Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri | 2009 | World Journal of Gastroenterology2009，15，26： | 19 |
| 2 | Intraoperative ERCP : 它在 laparoscopic 胆囊炎的时代有什么角色?显示文摘 In the treatment of patients with symptomatic cholelithiasis and choledocholithiasis (CBDS) detected during intraoperative cholangiography (IOC),or when the preoperative study of a patient at intermediate risk for CBDS cannot be completed due to the lack of imaging techniques required for confirmation,or if they are available and yield contradictory radiological and clinical results,patients can be treated using intraoperative endoscopic retrograde cholangiopancreatography (ERCP) during the laparoscopic treatment or postoperative ERCP if the IOC finds CBDS.The choice of treatment depends on the level of experience and availability of each option at each hospital.Intraoperative ERCP has the advantage of being a single-stage treatment and has a significant success rate,an easy learning curve,low morbidity involving a shorter hospital stay and lower costs than the two-stage treatments (postoperative and preoperative ERCP).Intraoperative ERCP is also a good salvage treatment when preoperative ERCP fails or when total laparoscopic management also fails. | Luis R Rábago Alejandro Ortega Inmaculada Chico David Collado Ana Olivares Jose Luis Castro Elvira Quintanilla | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，12： | 13 |
| 3 | Large-scale dendrimer-based uneven nanopatterns for the study of local arginine-glycine-aspartic acid (RGD) density effects on cell adhesion显示文摘 | Anna Lagunas Albert G. Castano Juan M. Artes Yolanda Vida Daniel Collado Ezequiel Perez-lnestrosa Pau Gorostiza Silvia Claros Jose A. Andrades Josep Samitier | 2014 | Nano Research2014，7，3： | 4 |
| 4 | A cross-cultural examination of interpersonal communication motives in Mexico and the United States显示文摘 | Rubin Rebecca B Carlos Fernandez Collado and Roberto Hernandez-Sampieri | 1992 | International Journal of Intercultural Relations1992，16，2： | 1 |
| 5 | Configurational and con- stitutional information storage: multiple dynamics in sys-terns based on pyridyl and acyl hydrazones 显示文摘 | Chaur M N Collado D Lehn J M | 2011 | Chem Eur J2011，17，1： | 1 |
| 6 | The role of expectations in the consumer satisfaction forma-tion process:Empirical evidence in the travel agency sector显示文摘 | IA Rodriguez del Bosque H San Martin J Collado | 2006 | Tourism Management2006，，27： | 1 |
| 7 | Early complications of endoscopic treatment for superficial bladder tumors显示文摘 | COLLADO A CHECHILE GE SALVADOR J | 2000 | J Urol2000，164，5： | 1 |
| 8 | Feasibility of Radical Transurethral Resection as Monotherapy for Selected Patients With Muscle Invasive Bladder Cancer显示文摘 | Eduardo Solsona Inmaculada Iborra Argimiro Collado José Rubio-Briones Juan Casanova Ana Calatrava | 2010 | The Journal of Urology2010，，2： | 1 |
| 9 | The power and the promise of oncogene-induced senescence markers显示文摘 | Collado M Serrano M | 2006 | Nat Rev Cancer2006，6，6： | 1 |
| 10 | A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors显示文摘 | Dankort D Filenova E Collado M | 2007 | Genes Dev2007，21，4： | 1 |
| 11 | Satellite remote sensing analysis to monitor desertification processes in the crop - rangeland boundary of Argentina显示文摘 | Collado A D Chuvieco E Camarasa A | 2002 | Journal of Arid Environments2002，52，1： | 1 |
| 12 | Gal microbiota composition is associated with body weight,weight gain and biochemical parameters in pregnant women 显示文摘 | SANTACRUZ A COLLADO M C GARCA-VALDI]S L | 2010 | Br J Nutr2010，104，1： | 1 |
| 13 | Effect of glucose in removal of microcystin - LR by viable com- mercial probi0tic strains and strains isolated from dadih fermented milk 显示文摘 | Nybom S A K Collado A C Surono I S | 2008 | Journal of Agricultural and Food Chemistry2008，56，10： | 1 |
| 14 | Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial 显示文摘 | Rautava S Collado MC Salminen S Isolauri E | 2011 | Neonatology2011，102，3： | 1 |
| 15 | The importance of applying a sentinel lymph node mapping algorithm in endometrial cancer staging: beyond removal of blue nodes 显示文摘 | Barlin JN Khoury - Collado F Kim CH | 2012 | Gynecol Oncol2012，125，3： | 1 |
| 16 | Factors affecting dental fear in French children aged 5-12 years显示文摘 | Nicolas E Bessadet M Collado V | 2010 | Int J Paediatr Dent2010，20，5： | 1 |
| 17 | Tumour biology: senescence in premalignant tumours 显示文摘 | Collado M Gil J Efeyan A | 2005 | Nature2005，436，7051： | 1 |
| 18 | Vasoactive intestinal peptide induces neuroendocrine differentiation in the LNCaP prostate cancer cell line through PKA, ERK, and PI3K显示文摘 | Guti6rrez-Cafias I Juarranz MG Collado B | 2005 | Prostate2005，63，1： | 1 |
| 19 | Super twisting control of a parametrically excited overiiead crane显示文摘 | VAZQUEZ C COLLADO J FRIDMAN L | 2014 | Journal of the Franklin Institute2014，351，4： | 1 |
| 20 | Properties of starch noodles as affected by sweet potato starch 显示文摘 | Collado LS Corke H | 1997 | Cereal Chemistry1997，74，2： | 1 |
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