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| 1 | 导致儿童期肥胖的生命早期危险因素:队列研究显示文摘目的确定早年(3岁以内)导致英国儿童肥胖的危险因素。设计前瞻性队列研究。方法Avon英国父母及儿童纵向调查研究。参与者参与队列研究的8234名年龄为7岁的儿童以及亚组的909名重点儿童,后者需额外提供与早期发育有关并涉及可能导致肥胖的各种资料。诊断标准7岁儿童体重指数≥95百分位确定为肥胖,参考1990年英国人口调查的诊断标准。结果经过最终验证,在假设的25项危险因素中有8项与肥胖有关:父母肥胖(父母双方校正后的相对危险度10.44,95%可信区间5.11~21.32);最早期(43个月内)的体重指数或体重反弹升高(校正后的相对危险度15.00,95%可信区间5.32~42.30);3岁时每周看电视的时间超过8小时(校正后的相对危险度1.55,95%可信区间1.13~2.12);追赶性生长(校正后的相对危险度2.60,95%可信区间1.09~6.16);8个月(校正后的相对危险度3.13,95%可信区间1.43~6.85)和18个月(校正后的相对危险度2.65,95%可信区间1.25~5.59)时体重的标准差值;1岁时体重增加值(校正后的相对危险度1.06,95%可信区间1.02~1.10,体重每增加100g);出生体重,每100g(校正后的相对危险度1.05,95%可信区间1.03~1.07);3岁时睡眠不足(<10.5小时,校正后的相对危险度1.45,95%可信区间1.10~1.89)。结论儿童期肥胖可能与8项危险因素有关。 | John J Reilly Julie Amstrong Ahmad R Dorosty Pauline M Emmett A Ness I Rogers Colin Steer Andrea Sherriff Children Study Team 冯凯 | 2005 | 英国医学杂志中文版2005，8，5： | 8 |
| 2 | Colonoscopy quality with Entonox? vs intravenous conscious sedation:18608 colonoscopy retrospective study显示文摘AIM To compare colonoscopy quality with nitrous oxide gas(Entonox?) against intravenous conscious sedation using midazolam plus opioid.METHODS A retrospective analysis was performed on a prospectively held database of 18608 colonoscopies carried out in Lothian health board hospitals between July 2013 and January 2016.The quality of colonoscopies performed with Entonox was compared to intravenous conscious sedation(abbreviated in this article as IVM).Furthermore,the quality of colonoscopies performed with an unmedicated group was compared to IVM.The study used the following key markers of colonoscopy quality:(1) patient comfort scores;(2) caecal intubation rates(CIRs); and (3) polyp detection rates (PDRs).We used binary logistic regression to model the data.RESULTS There was no difference in the rate of moderate-toextreme discomfort between the Entonox and IVM groups (17.9% vs 18.8%; OR = 1.06,95%CI: 0.95-1.18,P = 0.27).Patients in the unmedicated group were less likely to experience moderate-to-extreme discomfort than those in the IVM group(11.4% vs 18.8%; OR = 0.71,95%CI: 0.60-0.83,P < 0.001).There was no difference in caecal intubation between the Entonox and IVM groups(94.4% vs 93.7%; OR = 1.08,95%CI: 0.92-1.28,P = 0.34).There was no difference in caecal intubation between the unmedicated and IVM groups (94.2% vs 93.7%; OR = 0.98,95%CI: 0.79-1.22,P = 0.87).Polyp detection in the Entonox group was not different from IVM group (35.0% vs 33.1%; OR = 1.01,95%CI: 0.93-1.10,P = 0.79).Polyp detection in the unmedicated group was not significantly different from the IVM group (37.4% vs 33.1%; OR = 0.97,95%CI: 0.87-1.08,P = 0.60).CONCLUSION The use of Entonox was not associated with lower colonoscopy quality when compared to intravenous conscious sedation using midazolam plus opioid. | Alexander R Robertson Nicholas A Kennedy James A Robertson Nicholas I Church Colin L Noble | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 3 | System Xc-and apohpoprotein E expressed by micrnglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40显示文摘 | Qin S Colin C Hinners I | 2006 | J Ncurosci2006，26，12： | 1 |
| 4 | Optimization of a chirped-pulse amplification Nd:glass laser显示文摘 | Ross I N Mark Trentelman Colin N | 1997 | Appl Opt1997，36，36： | 1 |
| 5 | Direct toxic effect of iodide in excess on iodine deficient thyroid glands:epithelial necrosis and inflammation associated with lipofuscin accumulation显示文摘 | Mahmoud I Colin I Many MC | 1986 | Exp Mol Pathol1986，44，3： | 1 |
| 6 | System Xc-and applipoprotein Eexpressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptiden 1-40显示文摘 | Qin S Colin C Hinner I | 2006 | J Neurosic2006，26，12： | 1 |
| 7 | Direct toxic effect of iodide in excess on iodine-deficient thyroid glands:epithelial necrosis and inflammation associated with lipofuscin accumulation显示文摘 | MAHNZMOUD COLIN I MANY MC | 1986 | Experimental and Molecular Pathology1986，44，3： | 1 |
| 8 | miR-206 controls LXR alpha expression and promotes LXR-mediated cholesterol efflux in macrophages显示文摘 | Vinod M Chennamsetty I Colin S | 2014 | Biochim Biophys Acta2014，1841，6： | 1 |
| 9 | Counting the dead and what they died of an assessment of the global status of cause of death data显示文摘 | Colin DM Doris MF Mie I | 2005 | Bull WHO2005，83，： | 1 |
| 10 | Pharmacological character- isation of oxytocin binding sites in the ovine pineal gland 显示文摘 | Hamid R R David K M Colin D I | 1997 | Regulatory Peptides1997，70，： | 1 |
| 11 | Counting the dead and what they died of: an assessment of the global status of cause of death data 显示文摘 | Colin DM Doris MF Mie I | 2005 | Bull WHO2005，83，： | 1 |
| 12 | Optimization of a chirped-pulse amplification Nd:glass laser显示文摘 | Ross I N Mark T Colin N | 1997 | Appl Opt1997，36，36： | 1 |
| 13 | A review of drinking-water-associated endotoxin, including potential routes of human exposure 显示文摘 | William BA Robin MS Colin I | 2002 | Mayfield Can J Microbiol2002，48，： | 1 |
| 14 | Functional lymphocyte subset assessment of the Th1/Th2 profile in patients with autoimmune thyroiditis by flowcytometric analysis of peripheral lymphocytes显示文摘 | COLIN I M ISAAC J DUPRET P | 2004 | J Biol Regul Homeost Agents2004，18，1： | 1 |
| 15 | Resistin up-regulates fractalkine expression in human endothelial cells lack of addictive effect with TNF-alpha显示文摘 | Manduteanu I Dragomir E Colin M | | 0，，01： | 1 |
| 16 | mi R-206 controls LXRαexpression and promotes LXR-mediated cholesterol efflux in macrophages显示文摘 | Vinod M Chennamsetty I Colin S | 2014 | Biochim Biophys Acta2014，6，： | 1 |
| 17 | Economic globalization impacts on pacific marine resources 显示文摘 | I Hunt Colin | 2003 | Marine policy2003，27，1： | 1 |
| 18 | Microglia promote the death of developing Purkinje cells显示文摘 | Marin-Teva JL Dusart I Colin C | 2004 | Neuron2004，41，4： | 1 |
| 19 | The gonadotropin genes: evolution of distinct mechanisms for hormonal control 显示文摘 | Albanese C Colin I M Crowley W F | 1996 | Recent Progress in Hormone Research1996，51，： | 1 |
| 20 | Counting the dead and what they died of an assessment of the global status of cause of death da-ta显示文摘 | Colin DM Doris MF Mie I | 2005 | Bull WHO2005，83，： | 1 |
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