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| 1 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 2 | Behavior of natural fiber in stone matrix asphalt mixtures using two design methods显示文摘 | VALE D COLARES A CASAGRANDE M et a| | 2014 | Journal of Materials in Civil Engineering2014，26，3： | 1 |
| 3 | A gap theorem for complete scalar curvature hypersurfaces in the de Sitter space显示文摘 | Colares A G Palmas O | 2001 | J Geom Physics2001，37，： | 1 |
| 4 | Traditional walnut liqueur – cocktail of phenolics 显示文摘 | Stampar F Solar A Hudina M Veberic R Colaric M | 2006 | Food Chem2006，95，4： | 1 |
| 5 | A further characterization of ellipsoids显示文摘 | Alias L J Colares A G | 2005 | Results in Mathematics2005，48，： | 1 |
| 6 | Stability of hypersurfaces with constant r-mean curvature显示文摘 | Barbosa J L M Colares A G | 1997 | Annals of Global Analysis and Geometry1997，15，： | 1 |
| 7 | A gap theorem for complete scalar curvature hypersurfaces in the de Sitter space显示文摘 | Colares A G Palmas O | 2001 | J Geom Physics2001，37，： | 1 |
| 8 | Seasonal variations of se- lected flavonoids, phenolic acids and quinones in annual shoots of com- mon walnut (Juglans regia L)显示文摘 | SOLAR A COLARIC M USENIK V | 2006 | Plant Sci2006，170，3： | 1 |
| 9 | Cross-sectional study to determine viral hepatitis knowledge in different urban populations in Brazil显示文摘AIM To evaluate viral hepatitis knowledge among individuals from different resource areas and health conditions to identify possible gaps.METHODS A cross-sectional, descriptive study was carried out among 447 individuals from five distinct populations in Brazil: Southeast Viral Hepatitis Ambulatory(n = 100), South(n = 89) and Northeast(n = 114) Health Center, Southeast(n = 77) and Northeast(n = 67) low resource areas. All individuals answered a questionnaire assessing sociodemographic characteristics and viral hepatitis awareness. The perception was scored based on the average number of correct answers of all participants and categorized as 'low'(0-28 correct answers) or 'desirable'(29-46 correct answers). Associations between sociodemographic characteristics and perception were also evaluated.RESULTS A low level of knowledge was observed in individuals from Northeast Health Center, Northeast and Southeast low resource areas while desirable knowledge was observed in individuals from Viral Hepatitis Ambulatory and South Health Center. According to sociodemographic characteristics, desirable scores were more common among those with secondary education(47.1%), those who declared themselves as white(46.3%), and those who lived in houses with three individuals(25.5%). Multivariate analysis showed an association between viral hepatitis perception and type of population. CONCLUSION The results demonstrated high level of knowledge among study participants from health clinics from the Southeast region of Brazil and the importance of education programs in increasing the level of knowledge in low resource areas. | Helena Medina Cruz Jakeline Ribeiro Barbosa Jeová Keny Baima Colares Antonio Henrique Almeida de Moraes Neto Maria de Fátima Leal Alencar Francisco Inácio Bastos Jurema Corrêa da Mota Filipe Aníbal Carvalho-Costa Claudia Alexandra Pontes Ivantes Lia Laura Lewis-Ximenez Livia Melo Villar | 2018 | World Journal of Hepatology2018，10，11： | 1 |
| 10 | A further characterization of ellipsoids显示文摘 | ALiAS L J COLARES A G | 2005 | Results Math2005，48，： | 1 |
| 11 | Considering material heterogeneity in crack modeling of asphaltic mixture显示文摘 | SOARES J B COLARES F A ALLEN D H | 2003 | Journal of the Transportation Research Board2003，，： | 1 |
| 12 | Leaf epidermal characteristics of Lotus subgenus Acmlspon (Fabaceae: Loteae) and a numerical taxonomic evaluation 显示文摘 | Stenglein S A Arambarrl A M Colares M N | 2003 | Canadian Journal of Botany2003，81，： | 1 |
| 13 | Rigidity Results for Submanifolds with Parallel Mean Curvature Vector in the de Sitter Space显示文摘 | Brasil A Chaves R M B Colares A G | 2006 | Glasgow Mathematical Journal2006，48，1： | 1 |
| 14 | Behavior of natural fiber in stone matrix asphalt mixtures using two design methods 显示文摘 | Vale D Colares A Casagrande M | 2014 | Journal of Materials in Civil Engi- neering2014，26，3： | 1 |
| 15 | A gap theorem for copelte constant scalar curvature hypersurfaces in the de Sitter space显示文摘 | ALDIR Brasil J A Gervasio Colares Oscar Palmas | 2001 | J Geom Phys2001，37，： | 1 |
| 16 | Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats显示文摘BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver parenchyma.In animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant potential.AIM To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary cirrhosis.METHODS Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+MLT.MLT was administered(20 mg/kg)daily beginning on day 15 after biliary obstruction.On day 29 the animals were killed.Blood samples,liver tissue,and bone marrow were collected for further analysis.RESULTS BDL caused changes in biochemical and histological parameters and markers of inflammatory process.Thiobarbituric acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received MLT.DNA damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters. | Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni | 2022 | World Journal of Gastroenterology2022，28，3： | 1 |
| 17 | Traditional walnut liqueur-cocktail of phenolics显示文摘 | STAMPAR F SOLAR A HUDINA M VEBERIC R COLARIC M | 2006 | Food Chemistry2006，95，： | 1 |
| 18 | Complete spacelike hypersurfaces with constant mean curvature in thc de sitter space:a gap theorem显示文摘 | BRASIL J A COLARE A G PALMAS O | 2003 | ILLinois2003，，47： | 1 |
| 19 | Integral formulas for ther-mean curvature linearized operator of a hypersurface显示文摘 | Alencar H Colares A G | 1998 | Annals of Global Analysis and Geometry1998，16，： | 1 |
| 20 | Complete hypersurfaces with constant scalar curvature in spheres 显示文摘 | BRASIL Jr A COLARES A G PALMAS O | 2010 | Monatsh Math2010，161，4： | 1 |
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