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| 1 | The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline显示文摘 | Gaspar LE Mehta MP Patchell RA Burri SH Robinson PD Morris RE Ammirati M Andrews DW Asher AL Cobbs CS Kondziolka D Linskey ME Loeffler JS McDermott M Mikkelsen T Olson JJ Paleologos NA Ryken TC Kalkanis SN. | 2010 | 中国神经肿瘤杂志2010，8，1： | 98 |
| 2 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 3 | 美国统一州核心课程标准高中数学部分述评显示文摘2010年3月10日《美国统一州核心课程标准》(草案)开始对外征求意见,并已于6月初正式定稿并对外公布.这是由美国包括50个州长在内全美州长协会和美国州首席教育官员理事会共同研制.该标准的数学部分旨在解决美国数学不够连贯和重点的问题,解决美国数学课程宽泛而不够深入的问题,实现强调核心内容理解与建立核心内容之间的组织原则,以及提高学生的数学学习水平. | 曹一鸣 王立东 Paul Cobb | 2010 | 数学教育学报2010，19，5： | 38 |
| 4 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 5 | 中美教师高质量课堂教学观比较研究显示文摘比较分析中美两国教师的高质量教学观对于我国'素养化'教学改革,提高教学质量具有重要的现实意义。基于半结构式访谈,对中美两国各二十名优秀教师的高质量课堂教学观进行比较分析,得出的主要结论有:两国教师均认可高质量课堂学生积极参与,课堂气氛活跃融洽,基于精心的教学设计;两国教师在高质量课堂的教学方式选择、教学目标表述、课堂互动侧重等方面存在差异;中国教师对高质量课堂教学认识的一致性高于美国教师;美国教师对高质量课堂教学的认识与课程标准的一致性高于中国教师。 | 李欣莲 曹一鸣 Paul Cobb | 2017 | 全球教育展望2017，46，5： | 10 |
| 6 | Does computed tomography permeability predict hemorrhagic transformation after ischemic stroke?显示文摘AIM: To use perfusion-derived permeability-surface area product maps to predict hemorrhagic transformation following thrombolytic treatment for acute ischemic stroke.METHODS: We retrospectively analyzed our prospectively kept acute stroke database over five consecutive months for patients with symptoms of acute ischemic stroke(AIS) who had computed tomography(CT) perfusion(CTP) done at arrival. Patients included in the analyses also had to have a follow-up CT. The permeability-surface area product maps(PS) was calculated for the side of the ischemia and/or infarction and for the contralateral unaffected side at the same level. The cerebral blood flow map was used to delineate the ischemic territory. Next, a region of interest was drawn at the centre of this territory on the PS parametric map. Finally, a mirror region of interest was created on the contralateral side at the same level. The relative permeability-surface area product maps(r PS) provided an internal control and was calculated as the ratio of the PS on the side of the AIS to the PS on the contralateral side. A student t-test was performed after log conversion of r PS between patients with and without hemorrhagic transformation. Log conversion was used to convert the data into normal distribution to use t-test. For the group of patients who experienced intracranial bleed, a student t-test was performed between those with only petechial hemorrhage and those with more severe parenchymal hematoma with subarachnoid haemorrhage.RESULTS: Of 84 patients with AIS and CTP at admission, only 42 patients had a follow-up CT. The r PSderived using the normal side as the internal control was significantly higher(P = 0.003) for the 15 cases of hemorrhagic transformation(1.71 + 1.64) compared to 27 cases that did not have any(1.07 + 1.30). Patients with values above the overall mean r PS of 1.3 had an increased likelihood of subsequent hemorrhagic transformation. The sensitivity of using this score to predict hemorrhagic transformation was 71.4, the specificity was 78.6, with a positive predictive value of 62.5 and negative predictive value of 84.6. The accuracy was 76.2. The odds ratio of an event occurring with such an r PS was 9.2. Of the 15 cases of hemorrhagic transformation, there was no difference(P = 0.35) in the r PS between the eight cases of petechial and the seven cases of more severe hemorrhagic events.CONCLUSION: Pretreatment PS can predict the occurrence of hemorrhagic transformation on follow-up of AIS patients with relatively high sensitivity, specificity, positive and negative predictive value. | Peggy Yen Allison Cobb Jai Jai Shiva Shankar | 2016 | World Journal of Radiology2016，8，6： | 10 |
| 7 | Abnormal ground reaction forces lead to a general decline in gait speed in knee osteoarthritis patients显示文摘AIM To analyse ground reaction forces at higher speeds using another method to be more sensitive in assessing significant gait abnormalities. METHODS A total of 44 subjects, consisting of 24 knee osteoarthritis(OA) patients and 20 healthy controls were analysed. The knee OA patients were recruited from an orthopaedic clinic that were awaiting knee replacement. All subjects had their gait patterns during stance phase at top walking speed assessed on a validated treadmill instrumented with tandem force plates. Temporal measurements and ground reaction forces(GRFs) along with a novel impulse technique were collected for both limbs and a symmetry ratio was applied to all variables to assess inter-limb asymmetry. All continuous variables for each group were compared using a student t-test and χ2 analysis for categorical variables with significance set at α = 0.05. Receiver operator characteristics curves were utilised to determine best discriminating ability.RESULTS The knee OA patients were older(66 ± 7 years vs 53 ± 9 years, P = 0.01) and heavier(body mass index: 31 ± 6 vs 23 ± 7, P < 0.001) but had a similar gender ratio when compared to the control group. Knee OA patients were predictably slower at top walking speed(1.37 ± 0.23 m/s vs 2.00 ± 0.20 m/s, P < 0.0001) with shorter mean step length(79 ± 12 cm vs 99 ± 8 cm, P < 0.0001) and broader gait width(14 ± 5 cm vs 11 ± 3 cm, P = 0.015) than controls without any known lower-limb joint disease. At a matched mean speed(1.37 ± 0.23 vs 1.34 ± 0.07), ground reaction results revealed that pushoff forces and impulse were significantly(P < 0.0001) worse(18% and 12% respectively) for the knee OA patients when compared to the controls. Receiver operating characteristic curves analysis demonstrated total impulse to be the best discriminator of asymmetry, with an area under the curve of 0.902, with a cut-off of-3% and a specificity of 95% and sensitivity of 88%.CONCLUSION Abnormal GRFs in knee osteoarthritis are clearly evident at higher speeds. Analysing GRFs with another method may explain the general decline in knee OA patient's gait. | Anatole Vilhelm Wiik Adeel Aqil Mads Brevadt Gareth Jones Justin Cobb | 2017 | World Journal of Orthopedics2017，8，4： | 7 |
| 8 | Signal control through Raf: in sickness and in health显示文摘细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 串联是原型表明调整很多进程,包括的增长,区别,幸存,移植,压力回答和 apoptosis 的串联的哺乳动物的激活 mitogen 的蛋白质 kinase (MAPK ) 。这看起来线性的串联怎么被调制完成特定的细胞的功能,是这块地的一个主要焦点。在这评论,我们经由 MAP3Ks 在正常和疾病状态在 ERK1/2 小径的规定描述新以及旧的调查结果。 | Jihan K Osbome Elma Zaganjor Melanie H Cobb | 2012 | Cell Research2012，22，1： | 6 |
| 9 | microRNAs as oncogenes and tumor suppressors显示文摘 | Baohong Zhang Xiaoping Pan George P. Cobb Todd A. Anderson | 2006 | Developmental Biology2006，，1： | 5 |
| 10 | Mitogen-activated protein kinase pathways显示文摘 | Megan J Robinson Melanie H Cobb | 1997 | Current Opinion in Cell Biology1997，，2： | 4 |
| 11 | Non-alcoholic steatohepatitis and iron: increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis显示文摘 | Herbert L Bonkovsky Qaiser Jawaid Kristina Tortorelli Paula LeClair Joseph Cobb Richard W Lambrecht Barbara F Banner | 1999 | Journal of Hepatology1999，，3： | 2 |
| 12 | The roles played by interorganizational contracts and justice in marketing channel relationships显示文摘 | James R. Brown Anthony T. Cobb Robert F. Lusch | 2005 | Journal of Business Research2005，，2： | 2 |
| 13 | Mitogen-activated protein kinase pathways显示文摘 | Megan J Robinson Melanie H Cobb | 1997 | Current Opinion in Cell Biology1997，，2： | 2 |
| 14 | 健康与睡眠显示文摘 | Kristin Cobb 高一箴 朱天慧 | 2003 | 世界科学2003，，1： | 2 |
| 15 | Fungal antioxidant pathways promote survival against neutrophils during infection显示文摘 | Leal Sixto M Vareechon Chairut Cowden Susan Cobb Brian A Latgé Jean-Paul Momany Michelle Pearlman Eric | 2012 | EN2012，，7： | 2 |
| 16 | Plant microRNA: A small regulatory molecule with big impact显示文摘 | Baohong Zhang Xiaoping Pan George P. Cobb Todd A. Anderson | 2005 | Developmental Biology2005，，1： | 2 |
| 17 | Effective interventions for lifestyle change after myocardial infarction or coronary artery revascularization显示文摘 | COBB S L BROWN D J DAVIS L L | 2006 | J Am Acad Nurs Pract2006，18，1： | 1 |
| 18 | Social support as a moderator of life stress显示文摘 | Cobb S | 1976 | Psychosomatic Medicine1976，38，： | 1 |
| 19 | Effect of the class Ⅲ antiarrhythmic drug dofetilide on ventricular monophasic action potential duration and QT interval dispersion in stable angina pectoris显示文摘 | Rasmussen HS Cobbe SM | 1992 | Am J Cardiol1992，70，： | 1 |
| 20 | Social Support as a Moderator of Life Stress显示文摘 | Cobb S | 1976 | Psychosomatic Medicine1976，5，： | 1 |
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