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| 1 | Management of hepatocellular carcinoma with portal vein tumor thrombosis: Review and update at 2016显示文摘Portal vein tumor thrombosis(PVTT) is a common phenomenon in hepatocellular carcinoma(HCC). Compared to HCC without PVTT, HCC with PVTT is characterized by an aggressive disease course, worse hepatic function, a higher chance of complications related to portal hypertension and poorer tolerance to treatment. Conventionally, HCC with PVTT is grouped together with metastatic HCC during the planning of its management, and most patients are offered palliative treatment with sorafenib or other systemic agents. As a result, most data on the management of HCC with PVTT comes from subgroup analyses or retrospective series. In the past few years, there have been several updates on management of HCC with PVTT. First, it is evident that HCC with PVTT consists of heterogeneous subgroups with different prognoses. Different classifications have been proposed to stage the degree of portal vein invasion/thrombosis, suggesting that different treatment modalities may be individualized to patients with different risks. Second, more studies indicate that more aggressive treatment, including surgical resection or locoregional treatment, may benefit select HCC patients with PVTT. In this review, we aim to discussthe recent conceptual changes and summarize the data on the management of HCC with PVTT. | Stephen L Chan Charing CN Chong Anthony WH Chan Darren MC Poon Kenneth SH Chok | 2016 | World Journal of Gastroenterology2016，22，32： | 44 |
| 2 | Relationship between obesity and cardiovascular risk factors in elderly Chinese subjects显示文摘Objective To investigate the relative effects of degree and distribution of body fat with several cardiovascular disease (CVD) risk factors in elderly Chinese subjects.Methods One-hundred and thirty-five elderly Chinese individuals (age range, 60-65 y) without any history of significant renal, hepatic or cardiac disease were recruited. Seated blood pressure, anthropometric and fasting plasma biochemical parameters were measured. Student’s t-test was used to compare the differences in biochemical and anthropometric markers between cohorts.Results Males were heavier (64.6±8.6, 57.2±8.2?kg, P<0.001), taller (1.65±0.06, 1.51± 0.05 m, P<0.001) and their greater body fat was predominantly deposited centrally (Waist-to-hip ratio, 0.91±0.06, 0.88±0.07, P<0.05). Females were more generally obese with increased body mass index (BMI, 23.8±4.6, 25.0±3.5 kg/m 2, P<0.05) and percentage body fat [26.3% (24.5%-28.1%) vs 37.2% (36.0%-38.9%), P<0.001] than the males. However, despite an 11% higher proportion of body fat in females, no significant differences were identified in blood pressure, lipid profile, indices of insulin resistance or albumin-to-creatinine ratios.Conclusion It is likely that central adiposity contributes disproportionately to these metabolic disorders in males even though they are much leaner than elderly Chinese females. | G Neil THOMAS 赵海潞 马艳青 Wilson YS LEUNG Juliana CN CHAN Brian TOMLINSON Julian AJH CRITCHLEY 梁润成 陈重娥 汤宁信 郭志良 | 2002 | Chinese Medical Journal2002，，6： | 11 |
| 3 | Fluid Flow in Tundish Due to Different Type Arrangement of Weir and Dam显示文摘Tundish is an important metallurgical reactor in the continuous casting process. In order to control the fluid flow in tundish and thus take full advantage of the residence time available for the removal of inclusions from molten steel, the effect of weir and dam on the fluid flow has been studied in a water model based on the characteristic number Froude and Reynold number similarity criteria. The residence time distribution curves of the flow were measured by SG800, The optimum arrangement of dam and weir and the non- stationary flow in tundish were discussed. The results show that the combination of weir and dam is benefit for the flow pattern in tundish, weir can prevent the upper recirculating flow, dam can cut off the bottom flow and turn to upwards, it is advantageous to separate the nonmetallic inclusions. Furthermore, it is important to exceed the critical depth of bath during exchange ladles, not only for the inclusion floatation but also for avoiding tundish slag drainage earlier. | Yanping Bao, Wei Jiang,Baomei Xu, Haizhong Zhang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China E-mail: baoyp@metall .ustb .edu. cn | 2002 | Journal of University of Science and Technology Beijing2002，9，1： | 8 |
| 4 | 糖尿病,胰岛素和癌症风险显示文摘 There is a consensus that both type 1 and type 2 diabetes are associated with a spectrum of cancers but the underlying mechanisms are largely unknown.On the other hand,there are ongoing debates about the risk association of insulin use with cancer.We have briefly reviewed recent related research on exploration of risk factors for cancer and pharmacoepidemiological investigations into drug use in diabetes on the risk of cancer,as well as the current understanding of metabolic pathways implicated in intermediary metabolism and cellular growth.Based on the novel findings from the Hong Kong Diabetes Registry and consistent experimental evidence,we argue that use of insulin to control hyperglycemia is unlikely to contribute to increased cancer risk and that dysregulations in the AMPactivated protein kinase pathway due to reduced insulin action and insulin resistance,the insulin-like growth factor-1(IGF-1)-cholesterol synthesis pathway and renin-angiotensin system,presumably due to reduced insulin secretion and hyperglycemia,may play causal roles in the increased risk of cancer in diabetes.Further exploration into the possible causal relationships between abnormalities of these pathways and the risk of cancer in diabetes is warranted. | Juliana CN Chan | 2012 | World Journal of Diabetes2012，3，4： | 8 |
| 5 | EPP:一个与表情特征加工相关的ERPs晚期正成分显示文摘目的研究与表情特征加工相关的事件相关脑电位(event-reIated potentials,ERPs)成分。方法被试者为12名(7男5女)右利手健康大学生。刺激包括3种卡通面孔(中性、微笑、愤怒)和3种非面孔。要求被试者进行面孔识别(face recognition,FR)和面孔表情分类(facial expression cIassification,FEC)2种作业。记录32导脑电。结果 1)与FR任务相比,FEC任务产生明显的P580成分;2)FEC的ERP与FR的ERP的差异波形,表现出一个非常明显的中央一顶区分布的正差异(450~850ms),命名为表性加工正成分(expression processing positivity,EPP);3)EPP的峰值潜伏期表现出明显的表情特征主效应,以愤怒面孔EPP的潜伏期最短,微笑面孔EPP的潜伏期最长。结论 EPP可能反映了表情特征的晚期加工。 | 赵仑 赵昆 刘昌 Andrew CN Chen | 2006 | 航天医学与医学工程2006，19，1： | 8 |
| 6 | Identification of Porphyra lines using computerized DNA fingerprinting显示文摘RAPD (Randomly Amplified Polymorphic DNA) analysis was performed with filaments of 15 Porphyra lines representing four important groups (P. yezoensis, P. haitanensis, P. katadai var. Hemiphylla and P. digospermatangia). Eight stable and repeatable RAPD bands amplified with two primers, OPN-02 and OPJ-18, were selected for the construction of DNA fingerprinting. The RAPD results were scored based on the presence or absence of each of the 8 bands and then converted to computer language expressed with two digitals, 1 and 0, which represented the presence (numbered as 1) or absence (numbered as 0) of each band, respectively. Based on these results, a model DNA fingerprint and a computerized DNA fingerprint were constructed. In the constructed DNA fingerprint, each Porphyra line has its unique fingerprinting pattern and can be easily distinguished from each other. Later, a software, named as PhGI, was designed based on this DNA fingerprinting. It can be used in practical Porphyra line identification. | WangBin, Jia Jianhang, Shi Jinfeng, Chen Yihua, JinDemin, Xu Pu, Mei Junxue, Weng Manli 1. Institute of Genetics, Chinese Academy of Sciences, Beijing 100101 (E-mail: mlweng@genetics. ac. cn), China 2. Jiangsu Marine Fishery Institute, Nan | 2001 | Acta Oceanologica Sinica2001，20，3： | 7 |
| 7 | 吡啶系列原料国内市场分析显示文摘吡啶的生产方法有两种:一是从煤焦油中提取;二是从氨和甲醛、乙醛的合成过程中获得。我国一直采用前者生产,产量为200-300t/a,市场需求主要依靠进口,进口量最大的是比利时Reilly公司,1999年为2000多吨,占全国总消耗量的45%。2000年底,该公司与中国南通醋酸化工厂合作建立了1.1万t/a的吡啶系列产品生产厂,其中纯吡啶生产能力8000t/a、甲基吡啶3000t/a,填补了国内合成吡啶的空白。随着国内应用技术的发展,现已有多种用吡啶原料生产的产品打入国际市场。 | interehem. com. cn | 2001 | 精细与专用化学品2001，9，18： | 7 |
| 8 | Evidence for DNA Damage as a Biological Link Between Diabetes and Cancer显示文摘 | Shao Chin Lee Juliana CN Chan | 2015 | Chinese Medical Journal2015，，11： | 7 |
| 9 | 氯化镉影响肾上腺皮质细胞分泌功能的实验研究显示文摘目的 探讨CdCl2 对肾上腺皮质细胞分泌功能、细胞[Ca2 + ]i 调控和能量代谢的毒作用,为深入了解金属内分泌毒性机制提供依据。方法 体外分离培养原代豚鼠肾上腺皮质细胞,采用Fluo - 3/AM 和Fura- red/AM 联合标记、流式细胞术测定细胞[Ca2+ ]i 变化,化学发光法测定ATP 水平,RIA 法测定培养细胞皮质醇分泌水平。结果 ①CdCl2 可浓度依赖性地抑制肾上腺皮质细胞分泌皮质醇的功能,且随时间延长抑制效应愈趋明显,呈现明显的剂量效应和时间效应关系,剂量和时间对抑制效应存在交互作用;②细胞[Ca2 + ]i 随CdCl2 浓度增加而持续上升,表现出剂量效应关系。③细胞ATP 水平随CdCl2 浓度增加而降低,有明显的剂量效应和时间效应关系,而且存在交互作用。结论 一定浓度CdCl2 对肾上腺皮质细胞[Ca2+ ]i 调控、能量代谢和肾上腺皮质激素合成分泌具有直接毒作用。 | 杨杏芬 庄志雄 魏青 杜柳涛 赵敏 陈铁江 HM Shen CN Ong | 1999 | 中国职业医学1999，26，6： | 6 |
| 10 | CALCULUS ON FRACTALS BASED UPON LOCAL FIELDS─In memory of Founding Editor Professor M.T.Cheng with great respect and deep sorrow显示文摘The main contents in this note are: 1. introduction; 2. locally compact groups and local fields; 3. calculus on fractals based upon local fields; 4. fractional calculus and fractals; 5. fractal function spaces and PDE on fractals. | Su Weiyi(Department of Mathematics Nanjing University Nanjing, 210093 P. R. C e-mail: suqiu@nju. edu. cn) | 2000 | Analysis in Theory and Applications2000，16，1： | 6 |
| 11 | Pain perception and its genesis in the human brain显示文摘In the past two decades,pain perception in the human brain has been studied with EEG/MEG brain topography and PET/fMRI neuroimaging techniques.A host of cortical and subcortical loci can be activated by various nociceptive conditions.The activation in pain perception can be induced by physical(electrical,thermal,mechanical),chemical(capsacin,ascoric acid),psychological(anxiety,stress,nocebo) means,and pathological(e.g.migraine,neuropathic) diseases.This article deals mainly on the activation,but not modulation,of human pain in the brain.The brain areas identified are named pain representation,matrix,neuraxis,or signature.The sites are not uniformly isolated across various studies,but largely include a set of cores sites:thalamus and primary somatic area(SI),second somatic area(SII),insular cortex(IC),prefrontal cortex(PFC),cingulate,and parietal cortices.Other areas less reported and considered important in pain perception include brainstem,hippocampus,amygdala and supplementary motor area(SMA).The issues of pain perception basically encompass both the site and the mode of brain function.Although the site issue is delineared to a large degree,the mode issue has been much less explored.From the temporal dynamics,IC can be considered as the initial stage in genesis of pain perception as conscious suffering,the unique aversion in the human brain. | Andrew CN CHEN | 2008 | 生理学报2008，60，5： | 5 |
| 12 | 同型半胱氨酸水平、MTHFR基因突变与原发性高血压的病例对照研究(英文)显示文摘探讨升高的同型半胱氨酸水平、MTHFR基因突变与原发性高血压的关系。方法:从上海一个社区中随机选取127例35~75岁的原发性高血压病人和170例正常血压者。采用聚合酶链反应-限制性片段长度多态性分析MTHFR基因多态性。使用高效液相色谱结合电化学方法检测血清中同型半胱氨酸总浓度,使用放射免疫法同时测定血清中叶酸和B_(12)浓度。结果:调整年龄和性别后,病例和对照组同型半胱氨酸水平分别为 10.56 μmol/L和 10.34 μmol/L,差异无显著性(P=0.63)。在未服降压药的对象中同型半胱氨酸浓度与收缩压和舒张压亦无关联。该人群MTHFR不耐热性基因突变频率为13.1%,突变等位基因频率为38.7%。病例组与对照组基因型分布和突变等位基因频率无显著性差异。然而,病例组叶酸和B_(12)浓度高于对照组。结论:本研究未发现升高的同型半胱氨酸水平、MTHFR基因突变是原发性高血压的独立危险因素。高血压病人较高的叶酸和B_(12)水平可能降低了同型半胱氨酸的危险性。 | 詹思延 高原原 尹香君 胡永华 李立明 Vivian Ng Lee BL Ong CN | 2000 | 高血压杂志2000，8，1： | 5 |
| 13 | 城乡孕妇同型半胱氨酸代谢与神经管畸形的相关性研究显示文摘通过比较城乡早孕妇女血清同型半胱氨酸(Hcy)、叶酸和维生素B12水平,探讨Hcy代谢与神经管畸形城乡差异的关系。随机抽取北京地区早孕妇女血清库中411份血清(城市195份,乡村216份),用高效液相色谱结合电化学方法检测血清中Hcy浓度,放射免疫方法检测叶酸和维生素B12浓度。结果:乡村孕妇Hcy平均水平明显高于城市,分别为9.31μmol/L和5.73μmol/L;B12水平则低于城市,分别为210.09pmol/L和233.35pmol/L,叶酸水平虽高于城市,但叶酸缺乏率的差异不显著。乡村孕妇的叶酸/Hcy和B12/Hcy值均显著低于城市孕妇。提示Hcy代谢异常与乡村神经管畸形高发有关。 | 詹思延 胡永华 李立明 BL Lee Vivian Ng CN Ong | 1997 | 中华预防医学杂志1997，31，4： | 5 |
| 14 | 活性氧引起的人类精子DNA链断裂显示文摘为探讨活性氧对人类精子DNA的损伤作用 ,分别用 0、0 .0 6 2 5、0 .12 5、0 .2 5、0 .5及 1.0mM的H2 O2 和0、0 .1、1.0、2 .0、5 .0mM的 β NADPH在体外条件下处理精子 ,用单细胞凝胶电泳试验检测外源性H2 O2 和内源性O·-2 引起的精子细胞DNA链断裂。结果显示 :用 1.0mMH2 O2 或 5 .0mMNADPH处理精子 30min至 4h ,彗星细胞百分率显著增加 ,平均彗尾也显著增长 ,并有明显的作用时间 效应关系。精子细胞用 0 .0 6 2 5mM~ 1.0mMH2 O2 或 0 .1~ 5 .0mMNADPH处理 1h ,彗星细胞百分率与对照组比较显著增加 ,平均彗尾显著增长 ,并有明显的剂量 效应关系。这些研究结果表明 :外源性H2 O2 和β NADPH在体外条件下刺激精了细胞产生的内源性O·-2 | 徐德祥 Shen HM Ong CN | 2001 | 中国男科学杂志2001，15，3： | 4 |
| 15 | 二硫化碳慢性接触对儿茶酚胺类代谢的影响显示文摘采用综合累积暴露指数(ICE),将工人接触CS2浓度和接触期限结合起来定量评价暴露强度,并检测尿中2-硫代噻唑烷-4-羧酸(TTCA)和儿茶酚胺类神经递质代谢产物的含量。结果显示:接触组尿中TTCA增高,存在剂量-效应关系;高接触组高香草酸(HVA)和香草扁桃酸(VMA)排泄减少。这两种儿茶酚胺代谢产物与CS2浓度及工龄虽未显示有显著意义的相关,但与ICE及TTCA之间却呈现统计学上的相关关系,表明长期接触CS2对儿茶酚胺类神经递质代谢有一定的干扰作用。 | 杨杏芬 庄志雄 马林 谭炳炎 Lee BL New AL Ong HY Ong CN | 1996 | 中华劳动卫生职业病杂志1996，14，1： | 3 |
| 16 | 男性不育患者精子DNA中8-羟基脱氧鸟苷水平及与精液参数的相关性显示文摘本文应用高压液相 电化学 (HPLC EC)技术对 5 2名男性不育患者精子DNA中 8 羟基脱氧鸟苷 (8 OHdG)进行测定 ,同时检测精液量、精子密度、精子活率、正常形态精子率 ,及头部精子畸形等精液参数 ,并进行相关性分析。结果显示 ,当精子DNA中 8 OHdG超过 10 .5 0时 ,其头部畸形率明显增加。精子DNA中 8 OHdG与精液量 (r =- 0 .4 7,P <0 .0 0 1)、正常形态精子率 (r=- 0 .36 ,P <0 .0 1)成一定的负相关 ,且与头部畸形精子率成正相关 (r =0 .6 9,P <0 .0 0 1)。结果提示 ,精子DNA中 8 OHdG与精液质量存在一定的相关性 ,表明精液质量的下降与精子DNA的损伤存在一定联系 ,而内源及外源性活性氧是可能的原因之一 ,其可能的机制尚需进一步研究。 | 逄兵 金泰廙 蒋学之 Vivian NG Shen HM Ong CN | 2001 | 中国男科学杂志2001，15，3： | 3 |
| 17 | Existence of periodic solutions of the generalized Ginzburg-Landau equation with periodic boundary condition显示文摘In this paper, we study the periodic solution of the generalized Ginzburg-Landau equation by Galerkin method. We show the existence of periodic solution of this equation under appropriate conditions. | Boling GUO and Rong YUAN (Institute of Applied Physics and Computattonal Mathematics, Beijing 100088, China, e-mail: gbl@mail. iapcm. ac. Cn | 2000 | Communications in Nonlinear Science and Numerical Simulation2000，5，2： | 3 |
| 18 | Current status of bacteriological parameters and DOC/POC in Xiamen coastal waters显示文摘The surface and bottom waters samples were collected from six locations in Xiamen west-em sea. The quantified estimation of bacterial production (3H-thymidine method) and observation ofbacterial heterotrophic activity (14C-glucose method) have been made in order to have a better under-standing of the role of marine bacteria and their activities. The results showed that the mean value ofbacterial heterotrophic activity was 9 × 108 cells/(L. h) in the surface waters and 2.6 × 108 cells/( L. h)in the bottom waters. The mean value of bacterial production was 38 × 108 cells/( L. h) in the surfacewaters and 7.1 × 108 cells/(L.h) in the bottom waters. The relationship between bacterial production,heterotrophic activity, POC and DOC measured during this survey were discussed. The good under-standing of the relationship between bacteria activity and total coliform was addressed. | Khalid Maskaoui, Tianling Zheng , Huasheng Hong Zhiming Yu, Zhong Hu, Yun Tian, Lizhe Cai School of Life Sciences, Xiamen University, Xiamen 361005, ChinaKey Laboratory of Marine Environmental Science of SED, Xiamen 361005, ChinaKey Laboratory of Marine Ecology & Environmental Science, Chinese Academy of Sciences, Qingdao 266071, China + Corresponding author:86-592-2183217,Fax:86-592-2181510. E-mail: wshwzh @ jingxian. xmu. edu. cn | 2003 | Acta Oceanologica Sinica2003，22，3： | 2 |
| 19 | 精液叶酸、维生素B_(12)、活性氧水平与精子质量关系研究显示文摘目的 : 检测人精液叶酸、维生素 B12 ( VB12 ) ,及活性氧 ( ROS)的含量 ,探讨三者与精子质量的关系。方法 : 收集经证实配偶已怀孕的新加坡籍健康成年男性 1 76名的精液 ,根据WHO推荐方法检测精子质量各项指标 ,并测定精液叶酸和 VB12 含量及 ROS水平。结果 : 平均精液量、精子浓度和其活力都在正常范围内。而精子存活率 ( 73.0 6% )略低于 WHO标准 (≥ 75% ) ,形态异常的精子 ( 77.0 6% )高于 WHO标准 ( 70 % )。精液的叶酸含量与 ROS水平呈显著负相关 ( r=- 0 .2 5,P=0 .0 0 3) ;VB12 与 ROS呈负相关 ( r=- 0 .2 5,P=0 .0 0 2 ) ,与精子形态异常也呈负相关( r=- 0 .1 5,P=0 .0 4 8) ,但与精子浓度呈正相关 ( r=0 .31 ,P<0 .0 0 1 )。ROS与精子形态异常呈正相关 ( r=0 .2 5,P=0 .0 0 2 ) ,与精子活力也呈正相关 ( r=0 .1 9,P=0 .0 1 9)。结论 : VB12 对精子生成和维持精子正常功能是必需的 ,ROS水平与精子功能缺陷有关 ,VB12 和叶酸可能通过降低 ROS以维持精子的正常功能。 | 陈起萱 梅节 V Ng SE Chia 凌文华 CN Ong | 2001 | 营养学报2001，23，2： | 2 |
| 20 | Prevention of apoptosis by Bcl- 2: release of cytochrome c from mitochondria blocked 显示文摘 | Yang J Liu XS Kim CN | 1997 | Science1997，275，21： | 2 |
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