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| 1 | Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research. | Clifford Akateh Sylvester M Black Lanla Conteh Eric D Miller Anne Noonan Eric Elliott Timothy M Pawlik Allan Tsung Jordan M Cloyd | 2019 | World Journal of Gastroenterology2019，25，28： | 16 |
| 2 | Outpatient laparoscopic lumbar diskectomy: description of technique and review of first 21 cases显示文摘 | OBENCHAIN TG CLOYD D | 1994 | Surgi Technolo lnt1994，2，： | 1 |
| 3 | Laparoscopic lumbar discectomy: description of transperitoneal and retroperitoneal techniques显示文摘 | Obenchain TG Cloyd D | 1996 | Neurosurg Clin N Am1996，7，1： | 1 |
| 4 | En bloc resection of primary tumors of the cervical spine:report of two cases and systematic review of the literature显示文摘 | Cloyd JM Chou D Deviren V | | 0，，11： | 1 |
| 5 | Laparoscopic lumbar discectomy:description of transperitoneal and retroperitoneal techniques显示文摘 | Obenchain TG Cloyd D | 1996 | Neurosurg Clin N Am1996，7，1： | 1 |
| 6 | Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy 显示文摘 | PERUCCA E CLOYD J CRITCHLEY D | 2008 | Epilepsia2008，49，7： | 1 |
| 7 | Rufinamide: Clinical pharmaeokineties and concentration-response relationships in patients with epilepsy显示文摘 | PERUCCA E CLOYD J CRITCHLEY D | 2008 | Epilepsia2008，49，7： | 1 |
| 8 | Laparoscopic lumbar discectomy : descri-ption of transperitoneal and retroperitoneal techniques显示文摘 | Obenchain TG Cloyd D | 1996 | Neuro-surg Clin N Am1996，，： | 1 |
| 9 | Contemporary indications for and outcomes of hepatic resection for neuroendocrine liver metastases显示文摘BACKGROUND Although surgical resection is associated with the best long-term outcomes for neuroendocrine liver metastases(NELM),the current indications for and outcomes of surgery for NELM from a population perspective are not well understood.AIM To determine the current indications for and outcomes of liver resection(LR)for NELM using a population-based cohort.METHODS A retrospective review of the 2014-2017 American College of Surgeons National Surgical Quality Improvement Program and targeted hepatectomy databases was performed to identify patients who underwent LR for NELM.Perioperative characteristics and 30-d morbidity and mortality were analyzed.RESULTS Among 669 patients who underwent LR for NELM,the median age was 60(interquartile range:51-67)and 51%were male.While the number of metastases resected ranged from 1 to 9,the most common(45%)number of tumors resected was one.The majority(68%)of patients had a largest tumor size of<5 cm.Most patients underwent partial hepatectomy(71%)while fewer underwent a right or left hepatectomy or trisectionectomy.The majority of operations were open(82%)versus laparoscopic(17%)or robotic(1%).In addition,30%of patients underwent intraoperative ablation while 45%had another concomitant operation including cholecystectomy(28.8%),bowel resection(20.2%),or partial pancreatectomy(3.4%).Overall 30-d morbidity and mortality was 29%and 1.3%,respectively.On multivariate analysis,American Society of Anesthesiologists class≥3[odds ratios(OR),OR=2.089,95%confidence intervals(CI):1.197-3.645],open approach(OR=1.867,95%CI:1.148-3.036),right hepatectomy(OR=1.618,95%CI:1.014-2.582),and prolonged operative time of>230 min(OR=1.731,95%CI:1.168-2.565)were associated with higher 30-d morbidity while intraoperative ablation and concomitant procedures were not.CONCLUSION LR for NELM was performed with relatively low postoperative morbidity and mortality.Concomitant procedures performed at the time of LR did not increase morbidity. | Steven D Scoville Dimitrios Xourafas Aslam M Ejaz Allan Tsung Timothy Pawlik Jordan M Cloyd | 2020 | World Journal of Gastrointestinal Surgery2020，12，4： | 1 |
| 10 | Resistance of Greenhouse, Laboratory, and Native Populations of Western Flower Thrips to Spinosad显示文摘 | LOUGHNER R L WARNOCK D F CLOYD R A | 2005 | Hortscience2005，40，： | 1 |
| 11 | En bloc resection of primary tumors of the cervical spine:report of two cases and systematic review of the literature显示文摘 | Cloyd JM Chou D Deviren V | 2009 | Spine J2009，9，11： | 1 |
| 12 | Resistance of greenhouse,laboratory,and native populations of western flower thrips to spinosad显示文摘 | Loughner R L Warnock D F Cloyd R A | 2005 | Hortscience2005，40，： | 1 |
| 13 | Resistance of greenhouse, laboratory, and native populations of western flower thrips to spinosad显示文摘 | Loughner R L Warnock D F Cloyd R A | 2005 | Hortscience2005，，40： | 1 |
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